 | | Vol. 14.31 – 15 August, 2023 |
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| Researchers demonstrated that spheroids isolated from human and murine healthy pancreas and co-transplanted orthotopically with pancreatic ductal adenocarcinoma in mouse pancreas inhibited tumor growth.
[Journal Of Experimental & Clinical Cancer Research] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Investigators described a crucial system orchestrated by a transcriptional cofactor CtBP2. In cultured β cells, insulin gene expression was coactivated by CtBP2.
[Cell Reports] |
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| Using multiple 13C-labeled metabolic fuels, researchers demonstrated that stem cell-derived-islets showed numerous divergent patterns of metabolite trafficking in proposed insulin release pathways compared with primary human islets but were still reliant on mitochondrial aerobic metabolism to derive function.
[Cell Reports] |
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| Scientists proposed a new staging system incorporating distant metastasis, postoperative serum levels of CA19-9 and CEA, tumor size, lymph node metastasis, lymphovascular involvement, and perineural invasion to enhance the accuracy of prognosis assessment.
[iScience] |
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| Researchers showed an effective screening strategy with 3D cell aggregates based on cell viability and oxidative stress, which led to the discovery of several compounds with antioxidant capacity.
[Advanced Biology] |
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| Scientists developed a polyamino acid-based nanodrug incorporating the pancreatic stellate cells (PSCs) activation inhibitor calcipotriol and anti-CXCL12 siRNA. The nanodrug was easily prepared with a small particle size and was capable of penetrating pancreatic tumors to inactivate PSCs and downregulate CXCL12.
[Acta Biomaterialia] |
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| The authors established the utility of targeting a post-cleavage generated, surface-tethered oncogenic onco-mucin 16 carboxy-terminal domain by using a novel chimeric antibody in human IgG1 format, ch5E6, whose epitope expression directly correlated with disease severity in both cancers.
[NPJ Precision Oncology] |
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| Researchers showed that RNA polymerase II-associated factor 1 complex (PAF1C) was specifically required for survival of PDAC but not normal adult pancreatic cells.
[Cell Reports] |
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| Investigators studied how the impact of NCX activity on pancreatic stellate cell migration is modulated by cues from the tumor microenvironment.
[Pflugers Archiv-European Journal Of Physiology] |
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| Scientists detail more than 40 years of literature investigating the role of membrane-associated transport proteins in long-chain free fatty acids uptake. By focusing on what is known in other cell types, the authors highlight where we can extrapolate our current understanding of protein-mediated transport to beta cells.
[Diabetic Medicine] |
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| Dr. Sanjay Reddy, an Associate Professor in the Department of Surgical Oncology at Fox Chase Cancer Center, received an Investigator Initiated Clinical Trial grant from Fox Chase’s Office of Sponsored Research to study the impact of diet and lifestyle factors on pancreatic ductal adenocarcinoma.
[Fox Chase Cancer Center] |
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| The National Institutes of Health has awarded $2.6 million to a Virginia Tech team over five years for a study of high-frequency irreversible electroporation for tumor ablation and immune system activation in cases of pancreatic cancer.
[Vrginia Tech] |
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| October 2 – 4, 2023
Boston, Massachusetts, United States |
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| | Creative Biolabs – New York, New York, United States |
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| | Center for Excellence in Molecular Cell Science – Shanghai, China |
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| | National Institute of Health – Bethesda, Maryland, United States |
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| | Stanford University – Stanford, California, United States |
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| | Cedars-Sinai – Los Angeles, California, United States |
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