 | | Vol. 14.32 – 22 August, 2023 |
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| By monitoring both eurogenin 3 (NEUROG3) gene expression and protein in single cells using a knockin dual reporter in 2D and 3D models of human pancreas development, researchers showed an approximately two-fold slower expression of human NEUROG3 than that of the mouse.
[Developmental Cell] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| In vivo studies leveraging orthotopic implantation of pancreas cancer cells into wild-type and KLF10 KO mice revealed significant preservation of lean mass and robust suppression of pro-atrophy muscle-specific ubiquitin ligases Trim63 and Fbxo32.
[Proceedings Of The National Academy Of Sciences Of The United States Of America] |
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| Focusing on pancreatic islets, a type 2 diabetes relevant tissue, researchers showed that their model learned islet-specific transcription factor regulatory patterns and could be used to prioritize candidate causal variants.
[Proceedings Of The National Academy Of Sciences Of The United States Of America] |
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| RNAseq analysis indicated that, in both human and mice, early acinar cell dedifferentiation was accompanied by multiple pathways related to cell survival that were highly enriched, and where SLC7A11 was transiently upregulated.
[Cell Death & Disease] |
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| The authors presented an integrated map of islet cell type-specific gene expression from 192,203 cells from single cell RNA-sequencing of 65 non-diabetic, type 1 diabetes autoantibody positive, type 1 diabetic, and type 2 diabetic donors from the Human Pancreas Analysis Program.
[Diabetes] |
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| The lacto-ghrestatin derived nonapeptide, a bioactive peptide derived from lacto-ghrestatin in bovine milk with the sequence of LIVTQTMKG, was investigated to determine its effects on islet β cell dedifferentiation and associated mechanisms in type 2 diabetes mellitus.
[Food & Function] |
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| Investigators evaluated the anticancer effects of 1 and its analogs 2–4 against p53-mutated PANC-1 pancreatic cancer cells. They found that they possessed different DNA-alkylating properties in vitro.
[Journal Of Medicinal Chemistry] |
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| The metabolic data of 35 pancreatic tumor samples, 34 para-carcinoma samples, and 31 normal pancreatic tissues were obtained from the previously published literature. Pan-cancer samples were obtained from The Cancer Genome Atlas.
[Scientific Reports] |
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| Experiment results supported the notion that amphoteric regulatory protein (AREG) was overexpressed in pancreatic cancer tissues and cell lines. Functionally, the deletion of AREG impeded pancreatic cancer cell proliferation, migration, and invasion.
[Scientific Reports] |
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| Scientists review the dual roles that senescence plays in pancreatic ductal adenocarcinoma (PDA) development and progression, and the signaling effectors that critically regulate senescence in PDA.
[Cell Death & Disease] |
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| The FDA granted an orphan drug designation to the IgG1k type murine monoclonal antibody MAb-AR20.5 for the treatment of patients with pancreatic cancer, according to an announcement from CanariaBio.
[OncLive] |
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| Researchers with Sylvester Comprehensive Cancer Center at the University of Miami Miller School of Medicine have been awarded a grant from the US Department of Defense (DoD)’s Congressionally Directed Medical Research Program to target chemotherapy resistance in pancreatic cancer.
[Sylvester Comprehensive Cancer Center (News Medical Life Sciences)] |
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| October 18 – 21, 2023
EMBL Heidelberg and Virtual |
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| | University of Missouri – Columbia, Missouri, United States |
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| | Creative Biolabs – New York, New York, United States |
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| | Center for Excellence in Molecular Cell Science – Shanghai, China |
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| | National Institute of Health – Bethesda, Maryland, United States |
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| | Stanford University – Stanford, California, United States |
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