 | | Vol. 14.33 – 29 August, 2023 |
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| Scientists demonstrated that MRTX1133 reverses early PDAC growth, increased intratumoral CD8+ effector T cells, decreases myeloid infiltration, and reprogramed cancer-associated fibroblasts.
[Cancer Cell] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Focusing on pancreatic islets, a type 2 diabetes (T2D) relevant tissue, researchers showed that their model learned islet-specific transcription factor regulatory patterns and could be used to prioritize candidate causal variants.
[Proceedings Of The National Academy Of Sciences Of The United States Of America] |
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| Mice were treated with vehicle or metformin for more than four weeks to investigate the effects of metformin in vivo. In vitro, primary mouse hepatocytes and HepG2 cells were treated with two mmol/l metformin.
[Diabetologia] |
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| Researchers investigated the potential protective mechanism of morin against oxidative stress-induced damage caused by butylparaben (BP) in zebrafish larvae. They exposed the zebrafish larvae to BP or five days, leading to increased oxidative stress and apoptosis in β-cells. However
[Journal Of Biochemical And Molecular Toxicology] |
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| Investigators reported the bioactivity of the purified human pancreatic and duodenum homeobox 1 (PDX1) fusion protein using various assays like cell migration, proliferation, cell cycle analysis, and gene expression.
[Journal Of Biochemical And Molecular Toxicology] |
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| Scientists presented the single-cell transcriptomic landscape of synchronously resected pancreatic ductal adenocarcinoma primary tumors and matched liver metastases. They performed comparative analysis on both cellular composition and functional phenotype between primary and metastatic tumors.
[Nature Communications] |
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| To assess the mechanism that regulate Rab27a expression in PDAC, researchers used PDAC cell lines. The biological significance of these findings was validated in PDAC genetically engineered mouse models and human samples.
[Journal Of Translational Medicine] |
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| The authors found that the addition of aspirin enhanced the inhibitory effect of gemcitabine on the activity of PANC-1 and BxPC-3 cells. Quantitative N-glycoproteome, proteome, phosphorylation, and transcriptome data were obtained from integrated multi-omics analysis to evaluate the anti-tumor effects of aspirin and gemcitabine on pancreatic cancer cells.
[Cellular Oncology] |
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| Investigators discuss recent findings regarding the robust expansion of functional mature islet cells both in vivo and ex vivo through MYCL-mediated reprogramming.
[Current Opinion In Genetics & Development] |
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| Dr. Jeremy Pettus, an associate professor of medicine at UC San Diego Health, is leading a study on Liver Targeted Insulin in type 1 diabetes. The Leona M. and Harry B. Helmsley Charitable Trust recently provided a grant of more than $2 million to UC San Diego to support the research effort.
[UC San Diego] |
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| Queen’s Health Sciences researchers are part of a multi-institutional research team that will receive $2.4 million to advance cancer research and treatment.
[Queen’s University] |
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| October 20 – 24, 2023
Madrid, Spain |
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| | Cedars-Sinai – Los Angeles, California, United States |
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| | University of South California – Los Angeles, California, United States |
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| | University of Missouri – Columbia, Missouri, United States |
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| | Creative Biolabs – New York, New York, United States |
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| | Center for Excellence in Molecular Cell Science – Shanghai, China |
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