 | | Vol. 14.34 – 5 September, 2023 |
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| Using small-molecule drug-design approaches, the authors generated and validated PXS-5505, a first-in-class highly selective and potent pan-lysyl oxidase inhibitor.
[Nature Cancer] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Researchers uncovered a mechanism of adenosine monophosphate-activated protein kinase expression in the nonalcoholic fatty liver disease to nonalcoholic steatohepatitis transition, which was mediated by a nuclear mitogen-activated protein kinase (MAPK) phosphatase-1 (MKP1)/p38 MAPK-LKB1 axis.
[Nature Communications] |
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| Scientists integrated single-cell transcriptome, single-nuclei chromatin accessibility, and cell-type specific 3D genome profiles from human islets and identified type II diabetes-associated β-cell heterogeneity at both transcriptomic and epigenomic levels.
[Nature Communications] |
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| Investigators evaluated the in vitro differentiation potential of human omentum-derived mesenchymal stem cells cultured on an fibroblast growth factor 2-immobilized matrix and a round-bottom plate. Further, the in vivo therapeutic efficacy of the β-cells transplanted into kidney capsules was evaluated.
[Biomaterials Research] |
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| The lacto-ghrestatin derived nonapeptide, a bioactive peptide derived from lacto-ghrestatin in bovine milk with the sequence of LIVTQTMKG, was investigated to determine its effects on islet β-cell dedifferentiation and associated mechanisms in type 2 diabetes mellitus.
[Food & Function] |
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| Researchers hypothesized that disrupting the pH landscape during PDAC progression triggered pancreatic stellate cells and cancer-associated fibroblasts to induce PDAC fibrosis.
[JCI Insight] |
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| Investigators determined that the ST6GAL1 sialyltransferase, which adds α2,6-linked sialic acids to N-glycosylated proteins, was upregulated in patients with early-stage PDAC, and further increased in advanced disease.
[JCI Insight] |
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| Scientists investigated siRNA-mediated knockdown effects of sine oculis homeobox 4 (SIX4) on pancreatic cancer cells and underlying molecular mechanisms.
[Medical Oncology] |
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| Researchers investigated the functional role of cyclin-dependent kinase subunit 2 in pancreatic cancer (PC). An analysis of abnormally expressed genes and their prognostic value for PC was performed by using the Gene Expression Profiling Interactive Analysis database and performing immunohistochemical staining.
[Molecular Carcinogenesis] |
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| The authors summarize the botanical characterization, traditional use, chemical constituents, pharmacokinetics, and toxicology of mulberry leaves, and highlight the mechanisms involved in treating diabetes mellitus and its complications.
[American Journal Of Chinese Medicine] |
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| Ten years ago, a tech-savvy group of people with type 1 diabetes decided to pursue a DIY approach to their own treatment. They knew that a fairly straightforward piece of software could make their lives much easier, but no companies were developing it quickly enough.
[Nature News] |
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| October 1 – 4, 2023
Whistler, British Columbia, Canada |
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| | University of California – Los Angeles, California, United States |
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| | The Sidney Kimmel Cancer Center – Philadelphia, Pennsylvania, United States |
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| | Cedars-Sinai – Los Angeles, California, United States |
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| | University of South California – Los Angeles, California, United States |
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| | University of Missouri – Columbia, Missouri, United States |
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