 | | Vol. 14.36 – 19 September, 2023 |
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| Researchers identified a previously uncharacterized microprotein, Notch1 degradation-associated regulatory polypeptide (N1DARP), encoded by LINC00261. N1DARP knockout accelerated tumor progression and enhanced stem cell properties in pancreatic cancer organoids.
[Cell Discovery] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| The authors tested whether replacement of endogenous CDK4 with the inhibitor-resistant mutant CDK4-R24C rescued the loss of β cell mass in IRS2-deficient mice.
[Journal Of Clinical Investigation] |
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| To test whether blocking innate immaune cells modulated progression of the disease, scientists randomly assigned 273 individuals with stage 1 Type 1 diabetes (T1D) to treatment with hydroxychloroquine or placebo and assessed whether hydroxychloroquine treatment delayed or prevented progression to stage 2.
[Diabetes Care] |
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| Transcription factor EB (TFEB) overexpression was sufficient to inhibit insulin transcription, whereas beta cells depleted of both TFEB and TFE3 failed to suppress insulin gene expression in response to amino acid deprivation.
[EMBO Journal] |
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| The authors employed their recently established FOXA2-deficient iPSCs (FOXA2−/− iPSCs) to investigate changes in lncRNA profiles and their correlation with dysregulated mRNAs during the pancreatic progenitor and pancreatic islet stages.
[Cell Communication And Signaling] |
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| Investigators engineered a novel peptide-drug conjugate-based self-adaptive nanoregulator for mitigating dynamic immune evasion of PDAC.
[Advanced Materials] |
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| Genome-wide variations of DNA-methylation, messenger RNA and microRNA level as well as combinations thereof were analyzed in 345 tissue samples for marker identification. To improve diagnostic performance, researchers established a random-forest machine-learning approach.
[Gut] |
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| Scientists investigated sex disparities in clinical outcomes and tumor immune profiles in patients with PDAC who underwent upfront resection or resection preceded by gemcitabine-based neoadjuvant chemoradiotherapy.
[Gut] |
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| Targeting the protein subcomplex in pancreatic cancer stem cells with a KMT2A-WDR5 inhibitor attenuated their self-renewal capacity, cell viability, and in vivo tumorigenicity.
[Nature Communications] |
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| Scientists describe the metabolic changes that occur in the early pre-symptomatic stages of type 1 diabetes with respect to both insulin secretion and insulin sensitivity, as well as the measurable outcomes that can be derived from the available tests.
[Diabetologia] |
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| The authors elucidate the alterations in intracellular molecules and the extracellular environment that occur during the progression of PDAC.
[Cancer Letters] |
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| The National Institute for Health and Care Excellence (NICE) have published draft guidance approving the use of tirzepatide (brand name Mounjaro) for treating type 2 diabetes in England and Wales.
[Diabetes UK] |
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| October 16 – 19, 2023
Hong Kong |
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| | Beth Israel Deaconess Medical Center & Harvard Medical School – Boston, Massachusetts, United States |
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| | University of California, Los Angeles – Los Angeles, California, United States |
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| | Northwestern University – Chicago, Illinois, United States |
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| | University of California – Los Angeles, California, United States |
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| | University of Missouri – Columbia, Missouri, United States |
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Cancer Stem Cell News
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