 | | Vol. 14.37 – 26 September, 2023 |
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| By small molecule compound screening targeting 142 epigenetic enzymes, researchers identified that bromodomain-containing protein BRD9 was a key chromatin regulator to orchestrate the stemness of pancreatic cancer stem cells.
[Gastroenterology] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| The device showed the potential to enable subcutaneous survival of encapsulated islet cells, in vivo in awake, freely moving, immune-competent animals.
[Proceedings Of The National Academy Of Sciences Of The United States Of America] |
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| Researchers demonstrated that incorporating human pancreatic decellularized extracellular matrix within alginate microcapsules resulted in a significant increase in Glucose Stimulation Index and total insulin secreted by encapsulated human islets, compared to free islets and islets encapsulated in only alginate.
[Acta Biomaterialia] |
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| In this randomized and placebo-controlled trial, a total of 73 patients were randomly assigned to receive intravenous infusion of umbilical cord-derived mesenchymal stem cells or placebo, three times at four-week intervals and followed up for 48 weeks.
[Stem Cells Translational Medicine] |
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| Scientists describe scalable techniques for generating 10,000–100,000 organoids that further mature in 4–5 weeks into α- and β-like cells with glucose-responsive insulin and glucagon release.
[Star Protocols] |
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| Fructose could be taken up and metabolized by PDAC cells and provided an adaptive survival mechanism for PDAC cells under glucose deficient conditions.
[Cancer Research] |
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| In vivo and in vitro experiments revealed that fatty acid-binding protein 4 (FABP4) induced macrophage-related inflammation to promote pancreatic cancer cell migration, invasion, and metastasis under obese condition.
[Cancer Letters] |
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| Scientists demonstrated that CDK1 was correlated with prognosis and was highly expressed in pancreatic cancer tissue and gemcitabine-resistant cells
[Cell & Bioscience] |
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| Through multi-omics analyses, investigators discerned that solute carrier family 35 member F2 (SLC35F2) influenced the transcriptome and inhibited ferroptosis in pancreatic cancer cells.
[Oncogene] |
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| The authors discuss current state of the art and consider knowledge gaps concerning the interface of the islet beta cell with immune infiltrates, with a focus on T cells.
[Molecular Metabolism] |
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| Scientists describe how various nutrients are sensed, transported and metabolised in alpha cells, providing an integrative model for the metabolic regulation of glucagon secretion and action.
[Journal Of Endocrinology] |
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| The $5 million grant will enable Oncolytics to continue the next stage of its research focused on a clinical trial with Oncolytics’ proprietary reovirus pelareorep in combination with modified FOLFIRINOX chemotherapy, with or without an immune checkpoint inhibitor.
[Oncolytics Biotech Inc.] |
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| October 29 – November 1, 2023
New York, New York, United States |
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| | The University of Tennessee – Memphis, Tennessee, United States |
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| | Beth Israel Deaconess Medical Center & Harvard Medical School – Boston, Massachusetts, United States |
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| | Northwestern University – Chicago, Illinois, United States |
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| | The Sidney Kimmel Cancer Center – Philadelphia, Pennsylvania, United States |
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| | University of Missouri – Columbia, Missouri, United States |
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Cancer Stem Cell News
Cell Therapy News
Dermal Cell News
Endothelial Cell News
ESC & iPSC News
Extracellular Matrix News
Hematopoiesis News
Hepatic Cell News
Human Immunology News
Immune Regulation News
Intestinal Cell News
Mammary Cell News
Mesenchymal Cell News
Muscle Cell News
Neural Cell News
Organoid News
Pancreatic Cell News
Prostate Cell News
Pulmonary Cell News
