 | | Vol. 14.38 – 3 October, 2023 |
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| Investigators demonstrated the role of PAX4 in human endocrine cell development, beta cell function, and its contribution to type 2 diabetes risk.
[Nature Communications] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Scientists demonstrated that pancreatic tau was crucial for insulin secretion regulation and glucose homeostasis. Tau levels were found to be elevated in β-islet cells of patients with type 2 diabetes mellitus, and loss of tau enhanced insulin secretion in cell lines.
[Molecular Psychiatry] |
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| The authors developed a new type of endocrine pancreas-on-a-chip based on a microfiber assembly and evaluated its stimulation of pancreatic secretion by glucose or sugar substitutes.
[Advanced Healthcare Materials] |
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| To determine the role of Achaete-scute homolog 1 (Ascl1) in metabolic-stress induced β-cell failure, researchers generated pancreatic β-cell-specific Ascl1 knockout mice and assessed β-cell function and gene expression in response to a normal diet, metabolic stress, and excitotoxic stress.
[Molecular Metabolism] |
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| The authors selected C57BL/6 mice as lean mice models, ob/ob mice, or diet-induced obese mice as obese mice models and then induced experimental acute pancreatitis in mice via injections of caerulein.
[Cell Death Discovery] |
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| Scientists developed a highly sensitive assay to detect residual undifferentiated cells in islet cells derived from human chemically induced pluripotent stem cells, which were transgene-free and safer.
[Scientific Reports] |
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| The authors demonstrated that transcription factors myocyte enhancer factor 2A (MEF2A) and MEF2D synergistically regulated mechanistic target of rapamycin kinase complex 1 (MTORC1) activation via modulating its cyto-lysosome shutting.
[Autophagy] |
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| Researchers found that autotaxin, a secreted enzyme that promotes inflammation and fibrosis by generating lysophosphatidic acid, mediated adaptive resistance to TGFβ receptor inhibition.
[Cancer Research] |
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| Using cell models of colorectal and pancreatic cancers, investigators showed that cotreatment with Achyrocline B, a natural flavone from Achyrocline bogotensis, allowed for four-fold reduction in 5-flurouracil dosage without loss of efficacy.
[Biomedicine & Pharmacotherapy] |
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The authors summarize the present understanding of the crosstalk among tumor cells and the cellular immune microenvironment emphasizing the pro-malignant role played by extracellular vesicles in PDAC.
[Seminars In Cancer Biology] |
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| Salk Institute Assistant Professors Christina Towers and Deepshika Ramanan were named V Scholars by the V Foundation for Cancer Research. They will each receive $600,000 over three years to fund their unique cancer research goals.
[Salk Institute] |
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| October 23 – 25, 2023
Toronto, Ontario, Canada |
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| | City of Hope – Duarte, California, United States |
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| | The University of Tennessee – Memphis, Tennessee, United States |
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| | Northwestern University – Chicago, Illinois, United States |
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| | Beth Israel Deaconess Medical Center & Harvard Medical School – Boston, Massachusetts, United States |
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| | The Sidney Kimmel Cancer Center – Philadelphia, Pennsylvania, United States |
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