Pancreatic Cell News Volume 14.41 | Oct 24 2023

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    2023-10-24 | PACN 14.41


    Pancreatic Cell News by STEMCELL Technologies
    Vol. 14.41 – 24 October, 2023
    TOP STORY

    Functional Interrogation of Twenty Type 2 Diabetes-Associated Genes Using Isogenic Human Embryonic Stem Cell-Derived β-Like Cells

    Investigators engineered isogenic knockout human embryonic stem cell lines for 20 genes associated with type 2 diabetes risk. They examined the impacts of each knockout on β cell differentiation, functions, and survival.
    [Cell Metabolism]

    Full ArticleGraphical Abstract
    Watch this webinar to learn the advantages of using primary human nasal epithelial cells to study Cystic Fibrosis.
    PUBLICATIONSRanked by the impact factor of the journal

    Adjudin Improves Beta Cell Maturation, Hepatic Glucose Uptake, and Glucose Homeostasis

    Researchers investigated the effects of adjudin, a small molecule identified in a beta cell screen using zebrafish, on pancreatic beta cells and diabetes conditions.
    [Diabetologia]

    Full Article

    Sirtuin4 Alleviates Severe Acute Pancreatitis by Regulating HIF-1α/HO-1 Mediated Ferroptosis

    Scientists found that the expression level of SIRT4 in human acute pancreatitis (AP) was downregulated by screening a public database, suggesting that SIRT4 may play a role in AP.
    [Cell Death & Disease]

    Full ArticleGraphical Abstract

    Single-Cell Transcriptome Profiling of Pancreatic Islets from Early Diabetic Mice Identifies Anxa10 for Ca2+ Allostasis toward β Cell Failure

    The authors discovered a diabetes-specific transcriptome landscape of endocrine and nonendocrine cell types with subpopulations of β and α cells.
    [Diabetes]

    Abstract

    Naringenin Protects Pancreatic β Cells in Diabetic Rat through Activation of Estrogen Receptor β

    Researchers isolated rat islets and a diabetic rat model to investigate the effects of naringenin on estrogen receptor signaling and the underlying mechanism of naringenin-mediated improvement of islet function in diabetes.
    [European Journal of Pharmacology]

    Abstract

    Glucocorticoid Receptor-NECAB1 Axis Can Negatively Regulate Insulin Secretion in Pancreatic β Cells

    Scientists assessed the effects of adipocyte-derived factors on the functioning of pancreatic β-cells.They found that D8CM suppressed insulin secretion in INS-1D cells due to reduced intracellular calcium levels.
    [Scientific Reports]

    Full Article

    Dual Targeted Extracellular Vesicles Regulate Oncogenic Genes in Advanced Pancreatic Cancer

    The authors reported a dual targeted extracellular vesicle carrying high loads of therapeutic RNA that effectively suppressed large PDAC tumors in mice.
    [Nature Communications]

    Full Article

    FOXQ1 Promotes Pancreatic Cancer Cell Proliferation, Tumor Stemness, Invasion, and Metastasis through Regulation of LDHA-Mediated Aerobic Glycolysis

    Investigators constructed the epithelial–mesenchymal transition (EMT)-related prognosis model to screen out that FOXQ1 probably involving in the EMT regulation, vital progress in pancreatic cancer development.
    [Cell Death & Disease]

    Full Article

    Mutant SF3B1 Promotes Malignancy in PDAC

    Scientists demonstrated that Sf3b1K700E alone was insufficient to induce malignant transformation of the murine pancreas, but that it increased the aggressiveness of PDAC if it co-occurred with mutated KRAS and p53.
    [eLife]

    Abstract
    As a scientist, how you separate the facts from the claims is just as important as how you separate your cells. See for yourself.
    REVIEWS

    Regulatory Role of RNA Modifications in the Treatment of Pancreatic Ductal Adenocarcinoma (PDAC)

    The authors provide a comprehensive overview of RNA modifications in PDAC treatment, encompassing their behaviors, mechanisms, and potential treatment targets.
    [Heliyon]

    Full Article
    INDUSTRY AND POLICY NEWS

    Zydus Receives US FDA Approval for ZITUVIO™ to Treat Adult Patients with Type 2 Diabetes Mellitus

    Zydus Lifesciences Limited announced that the US FDA approved its New Drug Application for ZITUVIO™, Sitagliptin, tablets, 25 mg, 50 mg, and 100 mg. The approval of ZITUVIO™ was based on research, development, regulatory, and manufacturing work performed by Zydus teams.
    [Zydus Lifesciences Limited (PR Newswire)]

    Press Release
    FEATURED EVENT

    AACR-KCA Joint Conference on Precision Medicine in Cancer

    November 15 – 17, 2023
    Seoul, Korea

    > See All Events

    JOB OPPORTUNITIES

    Postdoctoral Research Fellow – Pancreatic Cancer Metabolism

    University of Oklahoma Health Science Center – Oklahoma City, Oklahoma, United States

    Postdoctoral Research Associate – Genetic Epidemiology

    University of Southern California – Los Angeles, California, United States

    Clinical Research Coordinator – Pancreatic Research Program

    Cedars-Sinai – Los Angeles, California, United States

    Director – Center of Emphasis in Diabetes and Metabolism

    Texas Tech University Health Sciences Center El Paso – El Paso, Texas, United States

    Associate Professor – DNA Repair

    Stanford University – Stanford, California, United States

    > See All Jobs

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