 | | Vol. 14.42 – 31 October, 2023 |
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| Scientists showed that Lin28b/let-7 pathway was indispensable for modulating the expression of Wnt5a in tumor epithelium, which could be secreted and then up-regulated Lin28b in cancer-associated fibroblasts.
[Nature Communications] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Investigators evaluated the safety and efficacy of automated insulin delivery with the iLet bionic pancreas in adults with cystic fibrosis–related diabetes in a single-center, open-label, random-order, crossover trial.
[Diabetes Care] |
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| Researchers’ analysis in a mouse model revealed that β cells of multiparous mice lost their proliferative capacity and became unable to compensate for the increasing insulin demand, leading to hyperglycemia.
[Experimental & Molecular Medicine] |
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| The authors fabricated oxygen release biomaterials and developed an oxygenated scaffold culture platform to offer a better oxygen supply during 3D iPSC pancreatic differentiation.
[Advanced Healthcare Materials] |
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| Researchers investigated the role of high-density lipoprotein (HDL) in pancreatic necrosis in acute pancreatitis (AP). The roles of healthy human-derived HDL and apoA-I mimic peptide D4F were demonstrated in AP models in vivo and in vitro.
[International Immunopharmacology] |
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| MMP assay and western blot was conducted to investigate the effects of atorvastatin on apoptotic cascade with sesamol as a protective agent was conducted in MIN-6 cells.
[3 Biotech] |
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| The authors synthesized a novel pro-drug of triptolide which was formulated into an emulsion for in vitro and in vivo testing in rats and mice, and using human pancreatic cancer cell lines and patient-derived pancreatic tumor organoids.
[eLife] |
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| Scientists investigated the effect of angiopoietin-2 (Ang-2) protein in PDAC survival. They did so by comparing the associaton between circulating Ang-2 using enzyme-linked immunosorbent assay and the pancreatic tumor expression of Ang-2 using immunohistochemistry.
[Scientific Reports] |
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| The authors demonstrated that cell surface GRP78-directed chimeric antigen receptor T (CAR-T) cells effectively killed the human pancreatic cancer cell lines, and pancreatic cancer stem-like cells in vitro by a luciferase-based cytotoxicity assay.
[Translational Oncology] |
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| Scientists summarize the current information about dysregulation of splicing-related elements and aberrant splicing isoforms in PDAC, and describe their relationship with the development, progression, and/or aggressiveness of this dismal cancer.
[Journal of Experimental & Clinical Cancer Research] |
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| City of Hope® and TGen are leading an international group that has been awarded $4.5 million to validate a liquid biopsy for the early detection of pancreatic cancer.
[City of Hope] |
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| A new experimental approach to treating pancreatic cancer is progressing to the next step in making it available to more patients. After results from a small study, a phase II clinical trial has now opened to test the effectiveness of using an mRNA vaccine to fight one of the deadliest cancers.
[Memorial Sloan Kettering Cancer Center] |
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| November 26 – 29, 2023
Buxted Park, England, United Kingdom |
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| | Cedars-Sinai – Los Angeles, California, United States |
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| | University of Oklahoma Health Science Center – Oklahoma City, Oklahoma, United States |
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| | University of Southern California – Los Angeles, California, United States |
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| | Cedars-Sinai – Los Angeles, California, United States |
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| | Texas Tech University Health Sciences Center El Paso – El Paso, Texas, United States |
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