Pancreatic Cell News Volume 14.43 | Nov 07 023

    By
    Jamie Kang
    -
    0
    14







    2023-11-07 | PACN 14.42


    Pancreatic Cell News by STEMCELL Technologies
    Vol. 14.42 – 7 November, 2023
    TOP STORY

    Hyperinsulinemia Acts via Acinar Insulin Receptors To Initiate Pancreatic Cancer by Increasing Digestive Enzyme Production and Inflammation

    Researchers demonstrated that insulin receptors in KrasG12D-expressing pancreatic acinar cells were dispensable for glucose homeostasis but necessary for hyperinsulinemia-driven pancreatic intraepithelial neoplasia formation.
    [Cell Metabolism]

    AbstractGraphical Abstract
    New human primary cancer-sourced blood products, immune cell subsets, and more. Click to view products.
    PUBLICATIONSRanked by the impact factor of the journal

    RANKL/RANK Is Required for Cytokine-Induced Beta Cell Death; Osteoprotegerin, a RANKL Inhibitor, Reverses Rodent Type 1 Diabetes

    Scientists demonstrated that the RANK pathway mediates cytokine-induced rodent and human β cell death through RANK-TRAF6 interaction and induction of NF-κB activation.
    [Science Advances]

    Full Article

    Genetic Lineage Tracing Identifies Adaptive Mechanisms of Pancreatic Islet β Cells in Various Mouse Models of Diabetes with Distinct Age of Initiation

    Investigators applied high-fat diet and streptozotocin treatment diabetic mouse models, triggered at different ages, to pursue the cell fate transition of islet β cells.
    [Science China Life Sciences]

    Abstract

    Fenofibrate Alleviates Insulin Resistance by Reducing Tissue Inflammation in Obese Ovariectomized Mice

    Researchers investigated the effects of fenofibrate on insulin resistance and tissue inflammation in a high-fat diet-fed ovariectomized C57BL/6J mice, a mouse model of obese postmenopausal women.
    [Nutrition & Diabetes]

    Full Article

    Androgen-Induced Upregulation of CFTR in Pancreatic β-Cell Contributes to Hyperinsulinemia in PCOS Model

    Scientists investigated the contribution of androgen and cystic fibrosis transmembrane conductance regulator to the hypersecretion of insulin in polycystic ovarian syndrome (PCOS) and the underlying mechanism.
    [Endocrine]

    Abstract

    MST2 Methylation by PRMT5 Inhibits Hippo Signaling and Promotes Pancreatic Cancer Progression

    Scientists demonstrated that protein arginine methyltransferase 5 (PRMT5) contributed to inactivation of the Hippo signaling pathway in pancreatic cancer.
    [EMBO Journal]

    Full ArticleGraphical Abstract

    Netrin-1 Feedforward Mechanism Promotes Pancreatic Cancer Liver Metastasis via Hepatic Stellate Cell Activation, Retinoid, and ELF3 Signaling

    Investigators detected an upregulation of the neuronal axon guidance molecule Netrin-1 in PDAC liver metastases that signals through its dependence receptor, uncoordinated-5b, to facilitate metastasis in vitro and in vivo.
    [Cell Reports]

    Full Article

    A Novel Triptolide Analog Downregulates NF-kB and Induces Mitochondrial Apoptosis Pathways in Human Pancreatic Cancer

    Researchers synthesized a novel pro-drug of triptolide, (E)-19–Triptolide (CK21), which was formulated into an emulsion for in vitro and in vivo testing in rats and mice, and using human pancreatic cancer cell lines and patient-derived pancreatic tumor organoids.
    [eLife]

    Abstract

    CRISPR/Cas9-Mediated Knock-In of BRCA1/2 Mutations Restores Response to Olaparib in Pancreatic Cancer Cell Lines

    Scientists induced BRCA1 and BRCA2 mutations in PDAC cell-lines using a clustered regularly interspaced short palindromic repeats (CRISPR)/associated protein 9 (Cas9)-mediated knock-in technology.
    [Scientific Reports]

    Full Article
    Activate, expand, and differentiate your cells with cytokines, chemokines, and growth factors from STEMCELL Technologies.
    REVIEWS

    Obesity Associated Pancreatic Ductal Adenocarcinoma: Therapeutic Challenges

    The authors explore the broad impact of obesity-induced risk factors on the development and progression of PDAC, focusing on changes within the tumor microenvironment as they pertain to prevention, current therapeutic strategies, and more.
    [Seminars In Cancer Biology]

    Full Article
    INDUSTRY AND POLICY NEWS

    NexImmune, Yale, and JDRF Extend Research Partnership for Type 1 Diabetes

    NexImmune, Inc. announces the extension of the research partnership between NexImmune, Yale, and JDRF to explore the use of NexImmune’s AIM nanoparticles in combination with an anti-CD3 mAb to tolerize, deplete, or modulate diabetes antigen-specific T cells.
    [NexImmune, Inc.]

    Press Release
    FEATURED EVENT

    Cell Therapy for Autoimmune Disease Summit

    November 28 – 30, 2023
    Philadelphia, Pennsylvania, United States

    > See All Events

    JOB OPPORTUNITIES

    Research Technician – Type 1 Diabetes

    Helmholtz Association of German Research Centres – Memphis, Tennessee, United States

    Postdoctoral Scientist – Cancer Research Cluster

    Cedars-Sinai – Los Angeles, California, United States

    Postdoctoral Research Fellow – Pancreatic Cancer Metabolism

    University of Oklahoma Health Science Center – Oklahoma City, Oklahoma, United States

    Postdoctoral Research Associate – Genetic Epidemiology

    University of Southern California – Los Angeles, California, United States

    Clinical Research Coordinator – Pancreatic Research Program

    Cedars-Sinai – Los Angeles, California, United States

    > See All Jobs

    Submit an article, publication, job or event
    Brought to you by
    stemcell-logo-for newsletter-2
    Logo for the social media website X

    Brought to you by