 | | Vol. 14.44 – 14 November, 2023 |
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| Scientists reported two optogenetic methods for vagal-nerve stimulation that led to enhanced glucose-stimulated insulin secretion and to β cell proliferation in mice expressing choline acetyltransferase-channelrhodopsin 2.
[Nature Biomedical Engineering] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| The authors showed that mice with β cell ornithine decarboxylase (ODC) deletion were protected against toxin-induced diabetes, suggesting a cell-autonomous role of ODC during β cell stress.
[Cell Reports Medicine] |
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| Researchers explored the role of Notch signaling, a key regulator of the immune response, within the pancreatic ductal adenocarcinoma microenvironment.
[Cancer Immunology Research] |
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| The authors fabricated oxygen release biomaterials and developed an oxygenated scaffold culture platform to offer a better oxygen supply during 3D iPSC pancreatic differentiation.
[Advanced Healthcare Materials] |
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| Investigators demonstrated that the transcription factor, homeobox C6 (HOXC6), was overexpressedunologists Research Program at UMass Diabetes Center of Excellence in most PDACs, and its inhibition blocked PDAC tumor growth and metastasis.
[Cell Reports Medicine] |
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| Under diabetic conditions, the human beta cell line EndoC-βH1, db/db mouse, and human islets displayed dampened insulin and incretin signalings and reduced beta cell survival, which were alleviated by PAX6 overexpression.
[EMBO Molecular Medicine] |
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| To recapitulate the PDAC tumor microenvironment ex vivo, researchers co-cultured patient-derived PDAC cells with mesenchymal and vascular endothelial cells derived from human induced pluripotent stem cells to create a fused pancreatic cancer organoid in an air-liquid interface.
[Cell Reports] |
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| Investigators combined conditional genetic targeting in human islet cells, RNA sequencing, chromatin mapping with Cleavage Under Targets & Release Using Nuclease, and transplantation-based assays to determine HNF1α-regulated mechanisms in adult human pancreatic α and β cells.
[JCI Insight] |
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| Using a real-world database with matched genomic-transcriptomic molecular data, the authors characterized the distinct molecular correlates underlying clinical differences between patients with young-onset pancreatic cancer and patients with average-onset pancreatic cancer.
[JCO Precision Oncology] |
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| Compared with the high-fat-high-glucose diet group, TAU supplementation significantly reduced malondialdehyde levels and increased superoxide dismutase, total antioxidant capacity, and glutathione levels in the rat pancreas.
[Heliyon] |
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| Scientists summarize the hallmark features of ferroptosis and then analyze the exact mechanisms by which ferroptosis is precisely regulated at multiple levels and links.
[Archives Of Toxicology] |
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| The explosive national demand for weight management therapies and diabetes drugs like Ozempic — all of which are indicated for indefinite use — has become central in an ongoing policy debate over high drug costs and controversial tactics to manage them.
[STAT News] |
| | Shrewsbury High School chemistry teacher Jennifer Cuddy was the recipient of an American Association of Immunologists High School Teachers Program in Immunology Award that gave her an opportunity to spend the summer working in Diabetes Center of Excellence research laboratories.
[UMass Chan Medical School] |
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| December 2 – 6, 2023
Boston, Massachusetts, United States |
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| | Cedars-Sinai – Los Angeles, California, United States |
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| | Armenian Bioinformatics Institute – Yerevan, Armenia |
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| | Helmholtz Association of German Research Centres – Memphis, Tennessee, United States |
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| | Cedars-Sinai – Los Angeles, California, United States |
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| | University of Oklahoma Health Science Center – Oklahoma City, Oklahoma, United States |
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