 | | Vol. 14.45 – 21 November, 2023 |
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| Metabolome analyses unveiled a metabolic signature linked to both SERPINB3 and the basal-like/squamous subtype, characterized by heightened carnitine/acylcarnitine and amino acid metabolism, associated with poor prognosis in patients with PDAC and elevated cellular invasiveness.
[Cell Reports] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| The authors generated transgenic mice lacking RNA methyltransferase-like 3 (Mettl3) specifically in Pdx1+ pancreatic progenitor cells and found the mutant mice developed hyperglycemia and hypo-insulinemia at two weeks of age.
[Diabetes] |
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| Investigators applied high-fat diet and streptozotocin treatment diabetic mouse models, triggered at different ages, to pursue the cell fate transition of islet β cells.
[Science China Life Sciences] |
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| β-like cells were derived from iPSCs in a three-step protocol. RNA sequencing and bioinformatics analysis were carried out to screen the differentially expressed lncRNAs and identify the putative target genes separately.
[Cellular Signalling] |
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| Researchers showed in mice that the hydrogel was able to provide sufficient vasculature to support islet function and viability, when islets were used at a low islet volume fraction.
[Tissue Engineering Part A] |
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| Scientists conditionally deleted Robo2 in β cells of adult mice and observed their islet architecture following a two-month chase.
[Developmental Biology] |
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| Using liquid chromatography–tandem mass spectrometry-based lipid mediator profiling pancreatic stellate cells as well as primary human cancer-associated fibroblasts expressed enzymes and receptors to produce and respond to specialized pro-resolving mediators.
[Frontiers In Immunology] |
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| Human embryonic stem cells were genetically modified to stably overexpress ferritin using the CRISPR-Cas9 system. Cellular toxicity associated with ferritin overexpression and manganese supplementation were assessed based on cell viability, proliferation, and metabolic activity.
[Current Stem Cell Research & Therapy] |
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| Researchers developed a PDAC population model that simulated an individual patient’s age and stage at diagnosis, while replicating overall US cancer incidence and mortality rates. The model includes “cancer sojourn time,” serving as a proxy for the speed of cancer progression.
[Scientific Reports] |
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| Investigators highlight evidence that supports the relative preservation of amino acid-stimulated insulin secretion compared to glucose-stimulated insulin secretion in type 2 diabetes, and make the case for the therapeutic potential of amino acids.
[Amino Acids] |
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| | A renowned expert is joining the University of Alberta to research a critical underlying defect in all types of diabetes, with the goal of improving treatment, thanks to support through the Canada Excellence Research Chairs program.
[University of Alberta] |
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A UMass Lowell scientist is hoping to improve the quality of life for those with diabetes using innovative biomaterials and engineered cells and tissues, including an insulin-producing, bioengineered pancreas-like tissue.
[The University of Massachusetts Lowell] |
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| December 16 – 20, 2023
Waikoloa Beach, Hawaii, United States |
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| | Babraham Institute – Cambridge, England, United Kingdom |
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| | University of Oxford – Oxford, England, United Kingdom |
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| | Cedars-Sinai – Los Angeles, California, United States |
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| | Armenian Bioinformatics Institute – Yerevan, Armenia |
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| | Helmholtz Association of German Research Centres – Memphis, Tennessee, United States |
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