 | | Vol. 14.47 – 5 December, 2023 |
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| To identify early disease-driving events, researchers performed traditional and multiplexed pancreatic tissue imaging, sorted-islet cell transcriptomics and islet functional analysis of early-stage T2D and control donors.
[Nature] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Investigators evaluated associations between 11 circulating cytokines and hormones with T2D among a population of sub-Saharan Africans and tested for causal relationships using Mendelian randomization analyses.
[Genome Medicine] |
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| Scientists identified the changes in hypothalamic gene and protein expression that underlie impaired counterregulatory response (CRR) in a mouse model of defective CRR.
[Diabetologia] |
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| Researchers used experimental and computational techniques to investigate the relationship between functional networks, structural networks, and intrinsic -cell dynamics in slow and fast oscillating islets.
[eLife] |
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| The authors identified c-FOXP3+E-cadherin– epithelial cells in human pancreatic cancer tissues after radical resection by immunofluorescence co-staining.
[American Journal Of Physiology-Cell Physiology] |
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| Non-obese diabetic mice were administrated with urolithin C (UC) to evaluate UC-mediated protection of type 1 diabetes. The inflammation of the pancreas islets was examined by hematoxylin and eosin staining.
[Nutrition & Diabetes] |
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| Investigators conducted targeted metabolomic analyses to detect bile acids changes in patients during the acute and the recovery phases of acute pancreatitis, as well as in healthy controls.
[Cell Reports Medicine] |
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| This study included 234 consecutively identified patients with germline BRCA PVs and a diagnosis of PDAC. Of patients with BRCA1, 33 of 69 were males with a median age of 63 years. Of patients with BRCA2, 84 of 165 were males, and the median age was 64 years.
[Jama Network Open] |
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| The authors elucidated the function of the nuclear receptor subfamily 5, group A, member 2 (NR5A2) in the context of pancreatic cancer stem cells.
[Journal of Experimental & Clinical Cancer Research] |
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| Researchers utilized proteomics as a valuable approach for cancer biomarker discovery; therefore, mass spectrometry-based proteomic profiling was conducted on plasma samples from 12 subjects to identify potential proteins capable of effectively distinguishing PanNET from healthy controls.
[Scientific Reports] |
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| Scientists provide an overview of the clinical evidence regarding disease staging, preoperative therapy, response evaluation and surgery in patients with borderline resectable pancreatic cancer or locally advanced pancreatic cancer.
[Nature Reviews Gastroenterology & Hepatology] |
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| Investigators discuss conflicting views of the relationship between pancreatic α-cells and β-cells and seek to understand how communication depends on blood flow and/or paracrine mechanisms.
[Diabetes] |
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| The Baker Centre for Pancreatic Cancer at London Health Sciences Centre (LHSC) opened in 2019 as part of the vision of Rick and Shelley Baker. They generously donated $1.5 million to support pancreatic cancer care and research in the London region after Rick was diagnosed with pancreatic cancer.
[London Health Sciences Centre] |
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| PhD student Jasmine Maghera, who was diagnosed with T1D when she was 11, remembers being told that five years from her diagnosis she wouldn’t need to take insulin anymore: technology would make injecting insulin obsolete. Now Maghera’s goal is to create and share that technology.
[University of Alberta] |
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| January 22 – 25, 2024
Santa Fe, New Mexico, United States |
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| | Albert-Ludwigs-University Freiburg – Freiburg im Breisgau, Germany |
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| | University of California San Francisco – San Francisco, California, United States |
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| | BC Cancer – Vancouver, British Columbia, Canada |
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| | Babraham Institute – Cambridge, England, United Kingdom |
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| | Baylor College of Medicine – Houston, Texas, United States |
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