 | | Vol. 14.48 – 12 December, 2023 |
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| In this Phase II, double-blind, randomized, placebo-controlled trial, scientists assigned patients with type 1 diabetes diagnosed during the previous 100 days to receive baricitinib or matched placebo orally for 48 weeks.
[New England Journal Of Medicine] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Researchers showed that the induction of neovascularization via temporary controlled inflammation through the implantation of a nylon catheter could be used to create a subcutaneous cavity that supported the transplantation and optimal function of a geometrically matching islet-encapsulation device.
[Nature Biomedical Engineering] |
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| The authors demonstrated a novel autocrine mechanism of β cell maintenance and function that was mediated by the peptide–amino acid transporter axis.
[Nature Communications] |
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| Investigators developed a method for selective genetic targeting of human α cells and assessed RFX6-dependent α cell function.
[Diabetes] |
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| Researchers highlighted the important roles of basic helix-loop-helix transcription factor 40 (BHLHE40)-mediated lipid peroxidation in inducing ferroptosis in pancreatic cancer (PCa) cells and provided a novel mechanism underlying sterol regulatory element-binding factor 1 (SREBF1) overexpression in PCa.
[Advanced Science] |
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| Investigators comprehensively unraveled the intra-patient response heterogeneity and intrinsic aggressive nature of PDAC on bulk and single-organoid resolution.
[NPJ Precision Oncology] |
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| Scientists tested the impact of basement membrane extract source on proliferation, drug response, and gene expression in mouse and human PDAC organoids.
[JCI Insight] |
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| The authors showed that SMAD4 status almost determined the orientation of transforming growth factor β1 (TGF-β1)-induced epithelial-mesenchymal transition via the SMAD4-dependent canonical pathway in PDAC, which altered ferroptosis vulnerability.
[Acta Pharmacologica Sinica] |
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| Scientists discovered that miR-211-5p was a significantly downregulated miRNA in pancreatic cancer tissues compared to adjacent non-tumor tissues.
[Aging] |
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| The authors detail the pancreatic expression of protein kinase D enzymes in normal individuals and pancreatitis and PDAC patients, as well as in mouse and rat animal models for these diseases.
[Biochimica Et Biophysica Acta-Molecular Cell Research] |
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| Some researchers publish a new paper every five days, on average. Data trackers suspect not all their manuscripts were produced through honest labor.
[Nature] |
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| February 14 – 18, 2024
Cancun, Mexico |
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| | Helmholtz Munich – Munich, Germany |
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| | Michigan State University – East Lansing, Michigan, United States |
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| | Albert-Ludwigs-University Freiburg – Freiburg im Breisgau, Germany |
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| | University of California San Francisco – San Francisco, California, United States |
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| | BC Cancer – Vancouver, British Columbia, Canada |
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