 | | Vol. 15.00 – 9 January, 2024 |
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| | Inhibition of an epidermal growth factor receptor/Erb-B2 receptor (EGFR/ERBB2)-signaling network in PDAC organoid-derived cultures and mouse models differentially impacted distinct cancer-associated fibroblasts subtypes, providing insights into mechanisms underpinning their heterogeneity. |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Scientists demonstrated that reducing ghrelin — by ghrelin gene knockout, conditional ghrelin cell ablation, or high-fat diet feeding — was associated with increased mean islet size, percentage of large islets, and β cell cross-sectional area.
[Journal Of Clinical Investigation] |
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| The authors showed, in β-cells from overweight humans without diabetes and mice fed a high-fat diet for two days, insulin exocytosis and secretion were enhanced without increased Ca2+ influx.
[Nature Communications] |
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| Researchers reported an insulin signaling–independent pathway able to improve glycemic control in type 1 diabetes mellitus rodents.
[Science Advances] |
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| The authors showed that the combined stimulation of specific mitogenic pathways, suppression of retinoic acid signaling, and inhibition of selected branches of the TGFβ and Wnt signaling pathways were necessary for the effective decoupling of pancreatic progenitors proliferation from differentiation.
[eLife] |
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| Differentiation of induced pluripotent stem cells (iPSC) into the pancreatic and endocrine lineage, combined with immunostaining, Western blotting and proteomics analysis, phenotypically characterized the insulin gene deficiency in SC-islets.
[Molecular Metabolism] |
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| Scientists reported a high-throughput drug-screening platform using a series of isogenic murine pancreatic organoids that were wild type or contain common PDAC driver mutations, representing both classical and basal PDAC phenotypes.
[Cell Stem Cell] |
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| Engrailed-1 predominantly repressed its target genes through direct binding to gene enhancers and promoters, implicating roles in the activation of MAPK pathways, and the acquisition of mesenchymal cell properties.
[Advanced Science] |
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| Pancreatic cancer incidence was compared according to weighted cumulative exposures to glucagon-like peptide-1 receptor agonists and to basal insulin in a Cox model implemented in discrete time, with time origin at two years after diabetes diagnosis, adjusting for confounding.
[Jama Network Open] |
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| Scientists discuss how the complexity of various tumor microenvironment components and the oncogenic signaling pathways that they are connected to actively contribute to the development and spread of PDAC, as well as the ways that recent therapeutic approaches have been targeted to restore it.
[Journal Of Controlled Release] |
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| The authors focus on the construction process and research progress with regard to organoids related to metabolic diseases in recent years, and looks forward to their prospective applications.
[Diabetes Obesity & Metabolism] |
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| The expected price hikes come as the pharmaceutical industry gears up for the Biden Administration to publish significantly discounted prices for 10 high-cost drugs in September, and continues to contend with higher inflation and manufacturing costs.
[Reuters] |
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| February 21 – 24, 2024
San Antonio, Texas, United States |
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| | Weill Cornell Medicine – New York City, New York, United States |
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| | Michigan State University – East Lansing, Michigan, United States |
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| | Albert-Ludwigs-University Freiburg – Freiburg im Breisgau, Germany |
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| | University of California San Francisco – San Francisco, California, United States |
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| | BC Cancer – Vancouver, British Columbia, Canada |
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