 | | Vol. 14.03 – 24 January, 2023 |
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| The authors reported that circGlis3 overexpression enhanced insulin secretion and inhibited obesity-induced apoptosis in vitro and in vivo.
[Nature Communications] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Investigators generated mice harboring an enzyme self-label genome-edited into the endogenous Glp1r locus. They also rationally designed and tested various fluorescent dyes, spanning cyan to far-red wavelengths, for labeling performance in tissue.
[Nature Communications] |
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| Researchers demonstrated that while β cell-specific TEAD1 deletion resulted in a cell-autonomous increase of β cell proliferation, β cell-specific deletion of its canonical coactivators, YAP and TAZ, did not affect proliferation, suggesting the involvement of other cofactors.
[Cell Reports] |
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| Scientists examined the role and source of preproglucagon peptides in β-cell function and in response to streptozotocin-induced hyperglycemia.
[American Journal Of Physiology-Endocrinology And Metabolism] |
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| Investigators established a PDAC platform that supported the understanding of treatment response of PDAC organoids in mono-, and co-culture with pancreatic stellate cells under hypoxic and normoxic conditions.
[Cell Death Discovery] |
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| Human pancreatic cancer cell lines were exposed to three different pancreatic stellate cells-conditioned media, following either pre-treatment with glycolysis inhibitor NV-5440 or transfection for transient silencing of key glycolytic regulators.
[Cancer Cell International] |
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| The authors refined an older methodology of PDAC detection by simultaneously measuring the serum miR-21-5p level and HSATII RNA level to enhance the detection of PDAC.
[iScience] |
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| Scientists showed that ribosomal RNA-processing 15 homolog (RRP15) expression was decreased in pancreatic cancer, and that RRP15 knockdown inhibited autophagy, and caused apoptosis in pancreatic cancer cells.
[Cell Biology International] |
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| Researchers tested the influence of phenolic acids on glucose and glutamine cellular uptake by a breast and a pancreatic, AsPC-1, cancer cell line.
[Canadian Journal Of Physiology And Pharmacology] |
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| Investigators discuss the models that have been developed for the pancreas, liver, kidney, nerves, and vasculature, how they complement other models, and their limitations.
[Nature Reviews Endocrinology] |
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| Scientists describe the clinical features of pancreatic cancer, review techniques for clearing and the 3D reconstruction of digitized microscope slides, and provide examples that illustrate how 3D visualization of human pancreatic cancer at the microscopic level has revealed features not apparent in 2D microscopy.
[Med] |
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| The Damon Runyon Cancer Research Foundation has announced eight recipients of the 2023 Damon Runyon-Rachleff Innovation Award, established to support “high-risk, high-reward” ideas with the potential to significantly impact the prevention, diagnosis, or treatment of cancer.
[Damon Runyon Cancer Research Foundation] |
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| Diabetes Canada announced the winners of their End Diabetes Awards research competition. Each of the winning research projects has the potential to unlock new insights and breakthroughs in the field of diabetes management, care, and risk reduction.
[Diabetes Canada] |
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| March 28 – 29, 2023
London, England, United Kingdom |
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| | Dresden University of Technology – Dresden, Germany |
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| | Imperial College London – London, United Kingdom |
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| | UT Southwestern Medical Center – Dallas, Texas, United States |
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| | European Molecular Biology Laboratory – Heidelberg, Germany |
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| | Vetex – Cambridge, Massachusetts, United States |
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