 | | Vol. 15.04 – 6 February, 2024 |
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| To determine the long-term effects of intermittent fasting (IF) on type 2 diabetes, 6-week-old KK and KKAy mice were subjected to IF for 16 weeks.
[Metabolism Clinical And Experimental] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Scientists explored whether β cell expression of Jagged1 determined the maladaptive Notch response and resultant insulin secretory defects in obese mice
[Molecular Metabolism] |
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| Researchers proposed a nano-encapsulation technique that could pave the way for significant advances in islet nano-encapsulation and the improvement of neonatal porcine islet-like cell cluster immaturity via T3 release, which may help to treat type 1 diabetes in humans.
[Discover Nano] |
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| Investigators compared the efficacy and safety of saxagliptin/dapagliflozin and insulin glargine in people with latent autoimmune diabetes in adults.
[Diabetes Obesity & Metabolism] |
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| Scientists observed that cytidine deaminase was overexpressed in pancreatic adenocarcinoma from patients at baseline and was essential for experimental tumor growth.
[Cancer Research] |
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| Researchers assessed the response to pharmacological inhibition of KRAS, the central oncogenic driver of PDAC. In a panel of PDAC cell lines, inhibition of KRASG12D with MRTX1133 yielded variable efficacy in suppressing cell growth and downstream gene expression programs in 2D cultures.
[Cancer Research] |
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| Scientists showed that Ru1 was capable of inhibiting cancer stem cells oxidative phosphorylation function in vitro. It presented excellent anti-cancer activity, with low toxicity, across a large panel of human pancreatic patient-derived xenografts (PDXs), as well as in colorectal cancer and osteosarcoma PDXs.
[Journal Of Experimental & Clinical Cancer Research] |
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| Researchers studied the efficacy of a telomerase-specific oncolytic adenovirus armed with the p53 gene for pancreatic cancer, focusing on its long-term effects via long-lived memory CD8+ T cells including tissue-resident memory T cells and effector memory T cells differentiated from effector memory precursor cells.
[British Journal Of Cancer] |
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| Scientists investigated the specific roles of DDX3X in PDAC. Multiple bioinformatics analyses were used to evaluate DDX3X expression and its potential role in PDAC. In vitro and in vivo studies were performed to assess the effects of DDX3X on PDAC cell growth.
[Oncogenesis] |
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| The authors explore the various islet-on-a-chip devices used to immobilize islets, regulate the microenvironment, and dynamically detect islet metabolism and insulin secretion.
[Lab On A Chip] |
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| Processa Pharmaceuticals, Inc. announced the successful completion of the safety tolerability evaluation in its Phase Ib trial of Next Generation Capecitabine.
[Processa Pharmaceuticals, Inc.] |
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| February 27 – 28, 2024
London, England, United Kingdom |
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| | Boston University – Boston, Massachusetts, United States |
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| | Cincinnati Children’s Hospital – Cincinnati, Ohio, United States |
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| | University of Galway – Galway, Ireland, United Kingdom |
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| | Medical College of Wisconsin – Milwaukee, Wisconsin, United States |
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| | Columbia University Irving Medical Center – New York, New York, United States |
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