 | | Vol. 15.05 – 13 February, 2024 |
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| Investigators identified the transcription factor Fos-related antigen-2 (Fra-2) as a miR-15a target mediating the adaptive mechanism of PDAC to nutrient deprivation.
[Signal Transduction And Targeted Therapy] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| The authors introduced FixNCut, a scRNA-seq approach where tissue is reversibly fixed with dithiobis(succinimidyl propionate) prior to dissociation and single-cell preparation. They applied FixNCut to an established mouse model of acute pancreatitis.
[Gastroenterology] |
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| Researchers reported that allogeneic transplantation of genetically engineered, primary, hypoimmune, pseudo-islets resulted in their engraftment into a fully immunocompetent, diabetic non-human primate wherein they provided stable endocrine function and enabled insulin independence.
[Cell Stem Cell] |
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| Investigators identified a marked up-regulation of DAP-related apoptosis-inducing kinase-2 (DRAK2) in pancreatic tissue across humans, macaques, and mice with type 2 diabetes.
[Science Translational Medicine] |
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| Human pluripotent stem cell derived pancreatic islets harboring WFS1 deficiency and mouse model of β cell specific Wfs1 knockout were applied to model β-cell failure in wolfram syndrome.
[Cell Death & Differentiation] |
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| Mogrol activated insulin secretion under low-glucose conditions in INS-1 pancreatic β-cells, which could be inhibited by a TGR5 inhibitor.
[Scientific Reports] |
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| Proteomics analysis revealed that aged fibroblasts secreted different factors than young fibroblasts, including increased growth/differentiation factor 15.
[Cancer Research] |
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| Scientists identified Glycogen synthase kinase 3 (GSK3) as a therapeutic target through a whole-body genetic screening utilizing a ‘4-hit’ Drosophila model mimicking the PDAC genotype.
[Cancer Science] |
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| Researchers showed that microtubule associated monooxygenase, calponin and LIM domain containing 2 (MICAL2) was highly expressed in pancreatic cancer tissue and exhibited potential diagnostic capability.
[Scientific Reports] |
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| The authors focus on the effects of a wide range of free fatty acids with crucial structural determinants for the development of lipotoxicity in human beta cells and document an association between increased triglyceride stores in obesity and in type 2 diabetes.
[Obesity Reviews] |
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| Universities must declare all their retractions and launch investigations into misconduct cases; a Nature analysis reveals that since 2021 there have been more than 17,000 Chinese co-authored retractions.
[Nature News] |
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| March 11 – 13, 2024
Lisbon, Portugal |
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| | Boston University – Boston, Massachusetts, United States |
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| | Cincinnati Children’s Hospital – Cincinnati, Ohio, United States |
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| | University of Galway – Galway, Ireland, United Kingdom |
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| | Columbia University Irving Medical Center – New York, New York, United States |
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| | Weill Cornell Medicine – New York City, New York, United States |
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