 | | Vol. 15.06 – 20 February, 2024 |
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| Researchers reported that allogeneic transplantation of genetically engineered, primary, hypoimmune, pseudo-islets resulted in their engraftment into a fully immunocompetent, diabetic non-human primate wherein they provided stable endocrine function and enabled insulin independence.
[Cell Stem Cell] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Cellular effects, including cell migration, focal adhesion formation and protein tyrosine kinase activity, induced by forced inter-alpha-trypsin inhibitor heavy chain 5 (ITIH5) expression in pancreatic cancer cell lines were studied in stable transfectants.
[Molecular Oncology] |
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| Scientists focused on the role of Pirfenidone (PFD) in diminishing fibrosis and immune response in chronic pancreatitis, using a mouse model induced by caerulein. The research extended to in vitro studies examining the influence of PFD on pancreatic stellate cells’ behavior and the polarization of macrophages.
[International Immunopharmacology] |
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| Investigators focused on pancreatic beta cells and tested the hypothesis that there was an association between intra- and extracellular ATP levels which depend on glucose provision.
[Cellular Signalling] |
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| Scientists presented the evidence for glucagon-like peptide 1 receptor (GLP1R) and glucose-dependent insulinotropic polypeptide receptor (GIPR) expression in the major islet cell types, before addressing signaling pathways engaged, as well as their influence on cell survival and function.
[Peptides] |
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| The authors found that the colonization of the hepatic metastatic site was accompanied by low-grade tissue injury and that efferocytosis-mediated clearance of parenchymal dead cells promoted macrophage reprogramming and liver metastasis.
[Nature Cancer] |
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| Using a mouse model of PDAC, researchers found that resistance was reproducibly associated with an epithelial-to-mesenchymal transition (EMT), with EMT-transcription factors ZEB1 and SNAIL functioning as master genetic and epigenetic regulators of this effect.
[Nature Communications] |
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| Since fibroblasts have profound impacts on pancreatic cancer progression, scientists investigated whether age-related changes in pancreatic fibroblasts influenced cancer growth and metastasis.
[Cancer Research] |
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| Scientists characterized cellular and acellular blood-based analytes in portal and peripheral blood before pancreatic manipulation, during tumor dissection and immediately after surgical resection to determine the effects of the surgery.
[NPJ Precision Oncology] |
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| The authors describe recent insights into G protein–coupled receptors signaling (GPCRs) and the importance of GPCR kinases function in modulating β-cell physiology.
[Pharmacological Reviews] |
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| Ipsen announced that the US FDA has approved the supplemental new drug application for Onivyde® plus oxaliplatin, fluorouracil, and leucovorin as a first-line treatment in adults living with metastatic pancreatic adenocarcinoma.
[Ipsen] |
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| March 18 – 19, 2024
London, England, United Kingdom |
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| | University of California, San Diego – La Jolla, California, United States |
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| | City of Hope – Monrovia, California, United States |
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| | UC Davis – Davis, California, United States |
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| | Cyprus Cancer Research Institute – Aglandjia, Cyprus |
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| | Boston University – Boston, Massachusetts, United States |
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