 | | Vol. 15.07 – 27 February, 2024 |
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| Investigators reported that N6-methyladenosine (m6A) was an adaptive β-cell safeguard mechanism that controled the amplitude and duration of the antiviral innate immune response at type 1 diabetes onset.
[Nature Cell Biology] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Scientists demonstrated that mAb43 binds to exocytotic sites on the β-cell surface, masking the antigenic exposure of ZnT8 and insulin following glucosestimulated insulin secretion.
[Diabetes] |
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| The authors investigated the effect of diabetes on ductal function. Diabetes was induced in wild-type and cystic fibrosis transmembrane conductance regulator knockout mice following an i.p. administration of streptozotocin.
[Journal Of Physiology] |
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| Scientists reported a detailed genetic characterization of youth-onset T2D by analysing exome sequences and common variant associations for 3,005 individuals with youth-onset T2D and 9,777 adult control participants matched for ancestry, including both males and females.
[Nature Metabolism] |
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| Investigators used the genetically engineered mouse model to map the spatiotemporal distribution of exosomes from healthy and PDAC pancreas in vivo to determine their biological significance.
[Nature Communications] |
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| Scientists reported a therapeutic strategy for p53Mut tumors based on abnormalities in the DNA repair response. Investigation of DNA repair upon challenge with thymidine analogs revealed a dysregulation in DNA repair response in p53Mut cells that led to accumulation of DNA breaks.
[Cell Reports Medicine] |
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| Researchers reported that fibrotropic minute virus of mice prototype specifically infected, replicated in and killed pancreatic cancer cells from murine and human origin with a mesenchymal, basal-like profile, while sparing cancer cells with an epithelial phenotype.
[Molecular Therapy Oncology] |
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| Pancreatic cancer cells were found to secrete high levels of ligands for C-X-C motif receptor 1 (CXCR1) and CXCR2.
[Molecular Therapy Oncology] |
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| The authors review the existing literature on the role of fusion genes in pancreatic tumors and their clinical potential as effective biomarkers and therapeutic targets.
[Trends In Cancer] |
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| Investigators provide a comprehensive overview of the risk of pancreatic cancer development in patients with inflammatory bowel disease.
[Alimentary Pharmacology & Therapeutics] |
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| A new diabetes research study is available in Warwick, R.I., to evaluate a non-drug procedure that may help improve blood sugar without increasing medicines or insulin. The combination of diabetes and obesity significantly increases one’s risk of heart attacks, stroke, liver disease, and other serious health problems.
[Fractyl Health (BusinessWire, Inc.)] |
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| The University of Cincinnati Cancer Center is the first site in the Midwest enrolling patients in a new Phase II clinical trial testing a vaccine to treat pancreatic cancer.
[University of Cincinnati] |
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| April 14 – 17, 2024
Glasgow, Scotland, United Kingdom |
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| | University of Exeter – Exeter, England, United Kingdom |
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| | City of Hope – Monrovia, California, United States |
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| | UC Davis – Davis, California, United States |
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| | Cyprus Cancer Research Institute – Aglandjia, Cyprus |
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| | Boston University – Boston, Massachusetts, United States |
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