Pancreatic Cell News Volume 15.10 | Mar 26 2024

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    Jamie Kang
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    2024-03-26 | PACN 15.10


    Pancreatic Cell News by STEMCELL Technologies
    Vol. 15.10 – 26 March, 2024
    TOP STORY

    Clonal Dominance Defines Metastatic Dissemination in Pancreatic Cancer

    Using patient-derived pancreatic cancer cells, the authors created orthotopically implanted clonal replica tumors to trace clonal dynamics of unperturbed tumor expansion and dissemination.
    [Science Advances]

    Full Article
    See how small molecules affect key signaling pathways in cancer research. Download your free wallchart now.
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    Inhibition of Glycogen Synthase Kinase-3 Enhances NRF2 Protein Stability, Nuclear Localization, and Target Gene Transcription in Pancreatic Beta Cells

    Scientists found that treating the pancreatic beta cell line INS-1 832/13 with the Kelch-like ECH-associated protein-1 (KEAP1) inhibitor TBE31 significantly enhanced NF-E2 p45-related factor-2 (NRF2) protein levels.
    [Redox Biology]

    Full Article

    The Porcine Islet-Derived Organoid Showed the Characteristics As Pancreatic Duct

    Researchers elucidated the characteristics of porcine islet organoids derived from porcine islets as a cell source for transplantation. Isolated porcine islets were 3D-cultured using growth factor-reduced matrigel in an organoid culture medium.
    [Scientific Reports]

    Full Article

    A Histone Methylation-MAPK Signaling Axis Drives Durable Epithelial-Mesenchymal Transition in Hypoxic Pancreatic Cancer

    Researchers showed that hypoxia drives long-lasting epithelial-mesenchymal transition (EMT) in PDAC primarily through a positive-feedback histone methylation-MAPK signaling axis.
    [Cancer Research]

    Abstract

    Auranofin Repurposing for Lung and Pancreatic Cancer: Low CA12 Expression as a Marker of Sensitivity in Patient-Derived Organoids, with Potentiated Efficacy by AKT Inhibition

    Our investigation employed a comprehensive drug screening of Auranofin in combination with eleven anticancer agents in cancerous PDAC and NSCLC patient-derived organoids, and non-cancerous pulmonary organoids.
    [Journal Of Experimental & Clinical Cancer Research]

    Full Article

    NNT-AS1 in CAFs-Derived Exosomes Promotes Progression and Glucose Metabolism through miR-889-3p/HIF-1α in Pancreatic Adenocarcinoma

    Transmission electron microscopy was used to examine exosomes secreted by PDAC patient-derived CAFs. qRT-PCR was used to evaluate the expression of NNT-AS1, miR-889-3p, and HIF-1.
    [Scientific Reports]

    Full Article
    Explore this validated protocol for high-efficiency gene editing of Human Pluripotent Stem Cells using the ArciTectâ„¢ CRISPR-Cas9 System.
    REVIEWS

    Retinol Binding Protein 4 and Type 2 Diabetes: From Insulin Resistance to Pancreatic β-Cell Function

    The authors update and summarize recent studies focused on the relationship between retinol-binding protein 4 and type 2 diabetes mellitus and its role in insulin resistance and pancreatic β-cell function to clarify the existing controversy and provide evidence for future studies.
    [Endocrine]

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    INDUSTRY AND POLICY NEWS

    Genprex Receives Notice of Patent Grant for Korean Patent Claiming Reqorsa® Immunogene Therapy with PD-1 and PD-L1 Antibodies to Treat Cancers

    Genprex, Inc. announced that the Korean Patent Office has issued a Notice of Patent Grant for a broad patent that covers the use of Genprex’s lead drug candidate, Reqorsa® Immunogene Therapy.
    [Genprex Inc.]

    Press Release
    FEATURED EVENT

    AACR Annual Meeting 2024

    April 7 – 10, 2024
    San Diego, California, United States

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    JOB OPPORTUNITIES

    Postdoctoral Position – Pancreatic Cancer Research

    Ume̴ University РUme̴, Sweden

    Associate Professor – Gastroenterology Issues

    University of Colorado – Aurora, Colorado, United States

    Postdoctoral Fellow – Vascular Biology and Diabetes

    City of Hope – Duarte, California, United States

    Research Assistants – Stem Cell-Derived Beta Cells

    King’s College London – London, England, United Kingdom

    Senior Research Lab Manager – Liver Disease

    Virginia Commonwealth University – Richmond, Virginia, United States

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