Pancreatic Cell News Volume 15.12 | Apr 23 2024

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    2024-04-23 | PACN 15.12


    Pancreatic Cell News by STEMCELL Technologies
    Vol. 15.12 – 23 April, 2024
    TOP STORY

    Effects of Hypertriglyceridemia with or without NEFA Elevation on β-Cell Function and Insulin Clearance and Sensitivity

    Researchers compared the glucometabolic effects of acute hypertriglyceridemia alone or combined with non-esterified fatty acids (NEFA) elevation in non-diabetic subjects.
    [Journal Of Clinical Endocrinology & Metabolism]

    Abstract
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    Mechanisms of Spinophilin-Dependent Pancreas Dysregulation in Obesity

    Scientists provided the first evidence that pancreatic spinophilin protein interactions were modulated by obesity and that loss of spinophilin specifically in pancreatic beta cells impacted whole-body glucose tolerance.
    [American Journal of Physiology – Endocrinology and Metabolism]

    Abstract

    Codetection of Proteins and RNAs on Extracellular Vesicles for Pancreatic Cancer Early Diagnosis

    Investigators analyzed the coexpressions of three protein markers and three RNA markers on extracellular vesicles from three pancreatic cell lines and 30 human plasma samples using codetection platform of proteins and RNAs.
    [Analytical Chemistry]

    AbstractGraphical Abstract

    PAFAH1B3 Is a KLF9 Target Gene that Promotes Proliferation and Metastasis in Pancreatic Cancer

    Researchers found that platelet-activating factor acetylhydrolase IB3 (PAFAH1B3) was highly expressed in pancreatic cancer tissues and cells. In vitro and in vivo studies showed that overexpression of PAFAH1B3 promoted the proliferation and invasion of pancreatic cancer cells.
    [Scientific Reports]

    Full Article

    MIF/NR3C2 Axis Regulates Glucose Metabolism Reprogramming in Pancreatic Cancer through MAPK-ERK and AP-1 Pathways

    Scientists provided evidence that migration inhibitory factor (MIF) and nuclear receptor subfamily 3 group C member 2 (NR3C2) interactively regulated metabolic reprogramming, resulting in MIF-induced cancer growth and progression in PDAC.
    [Carcinogenesis]

    Abstract
    Graphical Abstract
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    REVIEWS

    Quantitative MR Imaging Biomarkers for Distinguishing Inflammatory Pancreatic Mass and Pancreatic Cancer- A Systematic Review and Meta-Analysis

    The authors evaluated the diagnostic performance of quantitative magnetic resonance (MR) imaging biomarkers in distinguishing between inflammatory pancreatic masses and pancreatic cancer
    [European Radiology]

    Abstract
    INDUSTRY AND POLICY NEWS

    Roche and VinCense to Augment Access to Diabetes Care in Tamil Nadu

    Roche signed an agreement with VinCense to implement 3 programs in Tamil Nadu, screening 100,000 individuals over the next two years for diabetes and intervention for uncontrolled diabetes mellitus management and tuberculosis–diabetes mellitus co-morbidity management.
    [Express Healthcare]

    Press Release
    FEATURED EVENT

    Cell Symposia: Exercise Metabolism

    May 5 – 7, 2023
    Lisbon, Portugal

    > See All Events

    JOB OPPORTUNITIES

    Research Associate – X-Ray Diffraction of Pancreatic Cancer Tissue

    University of Ulster – Coleraine, Northern Ireland, United Kingdom

    Staff Scientist – Extracellular Vesicle in Diabetes Treatment

    City of Hope – Duarte, California, United States

    Staff Scientist – Myeloid Cell Regulation, Cancer, and Immunotherapy

    Wistar Institute – Philadelphia, Pennsylvania, United States

    Vice President – Pancreatic Cancer Canada

    Pancreatic Cancer Canada – Toronto, Ontario, Canada

    Postdoctoral Scientist – Cancer Research

    Cedars-Sinai Medical Center – Los Angeles, California, United States

    > See All Jobs

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