DIABETES A Subset of Interleukin-21 Chemokine Receptor CCR9 T Helper Cells Target Accessory Organs of the Digestive System in Autoimmunity CCR9+ T helper cells are a subset of interleukin 21-producing T helper cells that influence regional specification of autoimmune diseases that affect accessory organs of the digestive system. [Immunity] Insulin Restores Gestational Diabetes Mellitus-Reduced Adenosine Transport Involving Differential Expression of Insulin Receptor Isoforms in Human Umbilical Vein Endothelium Researchers aimed to determine whether insulin reverses gestational diabetes mellitus-reduced expression and activity of human equilibrative nucleoside transporters 1 in human umbilical vein endothelium cells. [Diabetes] Epidermal Growth Factor (EGF)-Receptor Signaling Is Needed for Murine Beta Cell Mass Expansion in Response to High-Fat Diet and Pregnancy But Not After Pancreatic Duct Ligation EGFR signaling is essential in beta cell mass expansion during a high-fat diet and pregnancy where replication is the primary mechanism for compensatory beta cell mass expansion. In contrast, EGFR signaling appears not to be crucial to increased beta cell proliferation after pancreatic duct ligation. [Diabetologia] Differentiation of Human Embryonic Stem Cells into Pancreatic Endoderm in Patterned Size-Controlled Clusters Production of functional β cells from human embryonic stem cells (hESCs) for patients with diabetes would benefit from the growth and differentiation of these cells in size-controlled aggregates. In this study, researchers controlled cluster size by seeding hESCs onto glass cover slips patterned by the covalent microcontact-printing of laminin in circular patches of 120 μm in diameter. [Stem Cell Res] PDX1- and NGN3-Mediated In Vitro Reprogramming of Human Bone Marrow-Derived Mesenchymal Stromal Cells into Pancreatic Endocrine Lineages Results indicate that establishment of glucose-dependent insulin secretion in partially reprogrammed human mesenchymal stromal/stem cells may depend on additional maturation factors. [Cytotherapy] Inhibition of ATP-Sensitive K+ Channels and L-Type Ca2+ Channels by Amiodarone Elicits Contradictory Effect on Insulin Secretion in MIN6 Cells Effects of amiodarone on ATP-sensitive K+ channels, L-type Ca2+ channel, membrane potential, and insulin secretion were examined and compared with those of quinidine in a β cell line (MIN6). [J Pharmacol Sci] Significance of Hydrogen Sulfide Production in the Pancreatic β Cell Researchers found that glucose stimulation increased cystathionine γ-lyase expression at transcript and protein levels in mouse pancreatic islets. They also found that H2S protects β cells that were chronically exposed to high glucose from apoptotic cell death. [J Pharmacol Sci] PANCREATIC CANCER Self-Powered Sensor for Naked-Eye Detection of Serum Trypsin Researchers report a device for the detection of the proteolytic enzyme trypsin, which is a biomarker for pancreatitis. [Anal Chem] Mesothelin Overexpression Promotes Autocrine IL-6/sIL-6R Trans-Signaling to Stimulate Pancreatic Cancer Cell Proliferation Data suggest that mesothelin-activated NF-κB induces elevated IL-6 expression, which acts as a growth factor to support pancreatic cancer cell survival/proliferation through a novel auto/paracrine IL-6/soluble IL-6R trans-signaling. [Carcinogenesis] Potential Role of NADPH Oxidase-Mediated Activation of Jak2/Stat3 and Mitogen-Activated Protein Kinases and Expression of TGF-β1 in the Pathophysiology of Acute Pancreatitis Inhibition of NADPH oxidase may be beneficial for prevention and treatment of pancreatitis by suppressing Janus kinase (Jak)2/signal transducers and activators of transcription (Stat)3 and mitogen-activated protein kinases and expression of transforming growth factor-β1 (TGF-β1) in pancreatic acinar cells. [Inflamm Res] |