DIABETES The Krüppel-Like Zinc Finger Protein GLIS3 Transactivates Neurogenin 3 for Proper Fetal Pancreatic Islet Differentiation in Mice Researchers aimed to elucidate the mechanism of action of GLIS family zinc finger 3 (GLIS3) in Glis3 -/- mice and to further decipher its action in in-vitro systems. [Diabetologia] Hepatic Nuclear Factor 1α (Hnf1α) Dysfunction Downregulates X-Box Binding Protein 1 (Xbp1) and Sensitises β-Cells to Endoplasmic Reticulum Stress Researchers have used an insulin-secreting cell line with inducible expression of dominant-negative Hnf1α, a transcription factor vital for correct β-cell development and function, to show that Hnf1α is required for Xbp1 transcription and maintenance of the normal endoplasmic reticulum stress response. [J Biol Chem] Diabetes and Pancreatic Exocrine Dysfunction due to Mutations in the Carboxyl-Ester Lipase Gene (CEL-MODY): A Protein Misfolding Disease As Cel knock-out mice do not express the phenotype and the mutant protein has an altered, intrinsically disordered tandem repeat domain, scientists hypothesized that the disease mechanism might involve a negative effect of the mutant protein. [J Biol Chem] L-Arginine Is Essential for Pancreatic Beta-Cell Functional Integrity, Metabolism and Defence from Inflammatory Challenge In this work the aim was to determine whether L arginine (a known insulinotropic amino acid) can promote a shift of β-cell intermediary metabolism favoring glutathione (GSH+GSSG) anti-oxidant responses, stimulus-secretion coupling, and functional integrity. [J Endocrinol] The Simplest Method for In Vitro β-Cell Production from Human Adult Stem Cells Here, researchers have attempted to differentiate adult stem cells from umbilical cord blood-derived mesenchymal cells, Wharton’s jelly-derived mesenchymal stem cells and amniotic epithelial stem cells into insulin-producing cells. [Differentiation] PANCREATIC CANCER Duct Cells Contribute to Regeneration of Endocrine and Acinar Cells Following Pancreatic Damage in Adult Mice To target specific types of pancreatic cells, scientists crossed R26DTR or R26DTR/lacZ mice with transgenic mice that express the Cre recombinase in the pancreas, under control of the Pdx1 (global pancreatic) or Elastase (acinar-specific) promoters. [Gastroenterology] Non-Redox-Active Lipoate Derivates Disrupt Cancer Cell Mitochondrial Metabolism and Are Potent Anticancer Agents In Vivo Researchers report the analysis of CPI-613, the first member of a large set of analogs of lipoic acid (lipoate) scientists have investigated as potential anticancer agents. [J Mol Med] High Expression of Galectin-1 in Pancreatic Stellate Cells Plays a Role in the Development and Maintenance of an Immunosuppressive Microenvironment in Pancreatic Cancer This study suggests that the overexpression of Galectin-1 in pancreatic stellate cells (PSCs) induced T cell apoptosis and Th2 cytokine secretion, which may regulate PSC-dependent immunoprivilege in the pancreatic cancer microenvironment. [Int J Cancer] Recurrent GNAS Mutations Define an Unexpected Pathway for Pancreatic Cyst Development To help reveal the pathogenesis of intraductal papillary mucinous neoplasm (IPMN), researchers purified the DNA from IPMN cyst fluids from 19 patients and searched for mutations in 169 genes commonly altered in human cancers. [Sci Transl Med] Stem-Like and Non-Stem Human Pancreatic Cancer Cells Distinguished by Morphology and Metastatic Behavior Researchers report here that XPA1 human pancreatic cancer cells are dimorphic. [J Cell Biochem] Cyclin-Dependent Kinase Inhibitor Dinaciclib (SCH727965) Inhibits Pancreatic Cancer Growth and Progression in Murine Xenograft Models In the current study, the therapeutic efficacy of SCH727965 on human pancreatic cancer cells was tested using in vitro and in vivo model systems. [Cancer Biol Ther] |