DIABETES Increased Neuronal Nitric Oxide Synthase Dimerisation Is Involved in Rat and Human Pancreatic Beta Cell Hyperactivity in Obesity The aim was to investigate whether changes in neuronal nitric oxide synthase function affect beta cell compensation in two relevant models: the Zucker fa/fa rats and pancreatic islets from obese humans. [Diabetologia] A Role for Glutamate Transporters in the Regulation of Insulin Secretion The data suggests that insulin secretion from β-cells is modulated by the flux of glutamate through the secretory granules. [PLoS One] Nkx2.2 and Arx Genetically Interact to Regulate Pancreatic Endocrine Cell Development and Endocrine Hormone Expression To begin to understand the cooperative functions of Nkx2.2 and Arx in the development of endocrine cell lineages, scientists generated progenitor cell-specific deletions of Arx on the Nkx2.2 null background. [Dev Biol] Activin, BMP and FGF Pathways Cooperate to Promote Endoderm and Pancreatic Lineage Cell Differentiation from Human Embryonic Stem Cells In this study, investigators describe the roles of growth factors bFGF, BMP4 and Activin A in early human embryonic stem cell fate determination. [Mech Dev] PANCREATIC CANCER Proteomic Analysis of an Immortalized Mouse Pancreatic Stellate Cell Line Identifies Differentially-Expressed Proteins in Activated vs. Non-Proliferating Cell States Researchers aimed to compare differentially expressed proteins from an immortalized cell line of mouse pancreatic stellate cells in the activated and serum-starved cell states using mass spectrometry-based proteomics. [J Proteome Res] Claudin-4 Expression Predicts Survival in Pancreatic Ductal Adenocarcinoma Using quantitative real-time reverse transcription-polymerase chain reaction, researchers analyzed CLDN4 mRNA expression in a panel of 9 pancreatic cancer cell lines and formalin-fixed paraffin-embedded tissues from 100 patients with pancreatic ductal adenocarcinoma. [Ann Surg Oncol] An Oncolytic Adenovirus Defective in pRb-Binding (dl922–947) Can Efficiently Eliminate Pancreatic Cancer Cells and Tumors In Vivo in Combination with 5-FU or Gemcitabine Researchers demonstrate that dl922–947 is highly efficacious in pancreatic cancers and conclude that oncolytic adenoviruses harboring the E1ACR2 deletion have great potential for development into future clinical candidates for pancreatic cancer. [Cancer Gene Ther] Over-Expression of FoxM1 Leads to Epithelial–Mesenchymal Transition and Cancer Stem Cell Phenotype in Pancreatic Cancer Cells Researchers established FoxM1 over-expressing pancreatic cancer (AsPC-1) cells, which showed increased cell growth, clonogenicity, and cell migration. [J Cell Biochem] Pluripotency-Associated Stem Cell Marker Expression in Proliferative Cell Cultures Derived from Adult Human Pancreas The aim of this study was to investigate expression of pluripotency-associated stem cell markers in proliferative cultures derived from adult human pancreas. [J Endocrinol] Transcriptional Activity of DNMT3B in Pancreatic Cancer Cells: Effects of −149 (C → T) Promoter Polymorphism The aim of this study was to investigate the effect of DNMT3B promoter genetic variant on its transcriptional activity and to compare activity in several pancreatic cell lines. [Biochem Biophys Res Commun] |