Pancreatic Cell News Volume 2.43 | Nov 1 2011

DIABETES

Synergistic Reversal of Type 1 Diabetes in NOD Mice with Anti-CD3 and Interleukin-1 Blockade Evidence of Improved Immune Regulation
Researchers postulated that blockade of interleukin-1ß would modulate the effects of anti-CD3 monoclonal antibody in treating diabetes in NOD mice. [Diabetes] Abstract

Susceptibility of Glucokinase-MODY Mutants to Inactivation by Oxidative Stress in Pancreatic β-Cells
Investigators tested the hypothesis that glucokinase (GK) mutants that cause maturity onset diabetes of the young (GK-MODY) show compromised activity and posttranslational regulation in β-cells. [Diabetes] Abstract

Immunohistochemical Characterization of Cells Co-Producing Insulin and Glucagon in the Developing Human Pancreas
Researchers sought to characterize the transcription factor profile of cells that co-produce insulin and glucagon in the developing human pancreas, and thus to gain insight into their potential fate during normal pancreas development. [Diabetologia] Abstract

Temporal Restriction of Pancreatic Branching Competence During Embryogenesis Is Mirrored in Differentiating Embryonic Stem Cells
In order to develop methods for the generation of insulin-producing β-cells for the treatment of diabetes, investigators have used GFP-tagged ESCs to elucidate the process of pancreas development. [Stem Cells Dev] Abstract

Ectopic PDX-1 Expression Directly Reprograms Human Keratinocytes Along Pancreatic Insulin-Producing Cells Fate
Scientists ectopically expressed non-integrating pancreatic differentiation factors in ectoderm-derived human keratinocytes to determine whether these factors could directly induce endoderm-derived pancreatic lineage and β-cell-like function. [PLoS One] Abstract

PANCREATIC CANCER

Characterization of dsRNA-Induced Pancreatitis Model Reveals the Regulatory Role of IFN Regulatory Factor 2 (Irf2) in Trypsinogen5 Gene Transcription
Researchers speculate that Trypsin5, the trypsinogen5 gene product, leaking from dead acinar cells triggers a chain reaction leading to lethal pancreatitis in mice deficient for interferon regulatory factor 2 (Irf2^-/- mice) because it is resistant to a major endogenous trypsin inhibitor, Spink3. [Proc Natl Acad Sci USA] Abstract

Copy Number Variation at 6q13 Functions as a Long-Range Regulator and Is Associated with Pancreatic Cancer Risk
The study examined the functional significance of CNVR2966.1 at 6q13 and its association with pancreatic cancer susceptibility. [Carcinogenesis] Abstract

MUC13 Mucin Augments Pancreatic Tumorigenesis
Scientists have investigated the expression profile and functions of MUC13 in pancreatic cancer progression. [Mol Cancer Ther] Abstract

Stem-Like and Non-Stem Human Pancreatic Cancer Cells Distinguished by Morphology and Metastatic Behavior
Researchers report here that XPA1 human pancreatic cancer cells are dimorphic. [J Cell Biochem] Abstract

OGX-427 Inhibits Tumor Progression and Enhances Gemcitabine Chemotherapy in Pancreatic Cancer
In this study, researchers demonstrate using tissue microarrays of 181 patients that heat shock protein 27 expression and phosphorylation levels increase in moderately differentiated tumors to become uniformly highly expressed in metastatic samples. [Cell Death Dis] Abstract | Press Release

ImaginAb, Inc. Awarded $2.3 Million from the National Cancer Institute
ImaginAb, Inc. announced that it has been awarded a total of $2.3 million in funding from the National Cancer Institute’s Small Business Innovation Research program to help further develop diagnostic imaging agents for Positron Emission Tomography. [ImaginAb, Inc.] Press Release

Halozyme Therapeutics Announces Data from Two Phase 1 Studies of PEGPH20 Demonstrating Targeting of Hyaluronan in Tumor Stroma
Halozyme Therapeutics, Inc. announced clinical trial results related to Halozyme’s clinical stage drug, pegylated rHuPH20 (PEGPH20). [Halozyme Therapeutics, Inc.] Press Release

Medtronic Receives IDE Approval to Conduct Aspire In-Home Study of First Insulin Pump with Low Glucose Suspend for US Market
In a continued commitment to develop an artificial pancreas, Medtronic, Inc. announced U.S. Food and Drug Administration approval of its Investigational Device Exemption (IDE) to conduct a pivotal in-home clinical trial protocol for the ASPIRE study of the MiniMed Paradigm® System featuring Low Glucose Suspend automation. [Medtronic, Inc.] Press Release

Type 1 Diabetes Mouse Resource (UC4) (RFA-DK-11-031) [National Institute of Diabetes and Digestive and Kidney Diseases, United States]

National Institutes of Health (United States)

Food and Drug Administration (United States)
 
Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

National Health Service (United Kingdom)

Therapeutic Goods Administration (Australia)

Lab Technologist – Tissue Culture (STEMCELL Technologies)

Research and Development Technologist, hPSC Media (STEMCELL Technologies) 

Scientist (iPSC) (STEMCELL Technologies)

Contract Assay Service Technologist (STEMCELL Technologies) 

Lab Technologist – Pluripotent Stem Cells (STEMCELL Technologies)

Scientist – Pluripotent Stem Cells (STEMCELL Technologies)

Quality Control Technologist – Cell Separation (STEMCELL Technologies)

Postdoctoral Fellowship in Pancreatic Cancer Research (Johns Hopkins University)

Postdoctoral Fellow – Islet Cell Electrophysiology (Vanderbilt University)    

Postdoctoral Scientist – Stem Cell Research (Lilly)

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