Pancreatic Cell News Volume 3.04 | Jan 31 2012

DIABETES

DNA Methylation Profiling Identifies Epigenetic Dysregulation in Pancreatic Islets from Type 2 Diabetic Patients
In this study, investigators performed the first comprehensive DNA methylation profiling in pancreatic islets from type 2 diabetic and non-diabetic donors. [EMBO J] Abstract

Glucose Activates Free Fatty Acid Receptor 1 Gene Transcription via Phosphatidylinositol-3-Kinase-Dependent O-GlcNAcylation of Pancreas-Duodenum Homeobox-1
The aims of this study were to test the hypothesis that glucose regulates G protein-coupled free fatty acid receptor-1 gene expression in pancreatic β-cells and to determine the mechanisms of this regulation. [Proc Natl Acad Sci USA] Abstract

Pancreatic Diabetes Manifests When Beta Cell Area Declines by Approximately 65% in Humans
Investigators aimed to determine the lower threshold of beta cell area for diabetes manifestation as well as the impact of insulin sensitivity on glucose homoeostasis in patients with pancreatic diabetes. [Diabetologia] Abstract

Comprehensive Phosphoproteome Analysis of INS-1 Pancreatic Beta-Cells Using Various Digestion Strategies Coupled with Liquid Chromatography-Tandem Mass Spectrometry
In this study, scientists attempted to generate data on a large-scale phosphoproteome from the INS-1 rat pancreatic beta-cell line using linear ion trap MS/MS. [J Proteome Res] Abstract

Pancreatic Ductal Cells Acquire Mesenchymal Characteristics through Cell Fusion with Bone Marrow-Derived Mesenchymal Stem Cells and Sirtuin 1 Attenuates the Apoptosis of Hybrid Cells
In this study, researchers investigated the effect of cell fusion on the biological characteristics of pancreatic ductal cells and on the survival mechanism of hybrid cells. [Cells Tissues Organs] Abstract

PANCREATIC CANCER

Atorvastatin Delays Progression of Pancreatic Lesions to Carcinoma by Regulating PI3/AKT Signaling in p48^Cre/+.LSL-Kras^G12D/+ Mice
The chemopreventive efficacy of the statin atorvastatin and the role of the phosphatidyl-inositol 3-kinase (PI3/AKT) signaling pathway were evaluated for the progression of pancreatic intraepithelial neoplasms to pancreatic ductal adenocarcinoma in conditional p48^Cre/+-LSL-Kras^G12D/+ transgenic mice. [Int J Cancer] Abstract

The RON-Receptor Regulates Pancreatic Cancer Cell Migration through Phosphorylation-Dependent Breakdown of the Hemidesmosome
To better understand RON function in pancreatic cancer cells, researchers sought to identify novel RON interactants using multidimensional protein identification analysis.[Int J Cancer] Abstract

Imexon Induces an Oxidative Endoplasmic Reticulum Stress Response in Pancreatic Cancer Cells
In this report, researchers investigate the effects of imexon on the integrated endoplasmic reticulum stress response in pancreatic carcinoma cells. [Mol Cancer Res] Abstract

Escin Augments the Efficacy of Gemcitabine through Down-Regulation of Nuclear Factor-κB and Nuclear Factor-κB-Regulated Gene Products in Pancreatic Cancer Both In Vitro and In Vivo
Here researchers investigated whether escin, via the inactivation of nuclear factor-κB, would potentiate the antitumor activity of gemcitabine in pancreatic cancer. [J Cancer Res Clin Oncol] Abstract

Joslin Diabetes Center Awarded $5 Million from Massachusetts Life Sciences Center
Joslin Diabetes Center (Joslin) has received a $5 million grant from the Massachusetts Life Sciences Center. Joslin will match the Center’s grant with $5.8 million raised from Joslin donors.  The total $10.8 million will be used to build a comprehensive Translational Center for the Cure of Diabetes at Joslin’s location in the heart of Boston’s Longwood Medical Area. [Joslin Diabetes Center] Press Release

Maryland Stem Cell Research Commission Announces New Program for Pre-Clinical and Clinical Research Grants
The Maryland Stem Cell Research Commission has announced a new program for pre-clinical and clinical research grants. This program will support for-profit companies in advancing medical therapies using human stem cells. [Maryland Stem Cell Research Fund] Press Release

FDA Approves BYDUREON™ – The First and Only Once-Weekly Treatment for Type 2 Diabetes
Amylin Pharmaceuticals, Inc. and Alkermes plc announced that the U.S. Food and Drug Administration (FDA) has approved BYDUREON™ – the first once-weekly treatment for type 2 diabetes. [Amylin Pharmaceuticals, Inc.] Press Release

Infinity Reports Update from Phase II Study of Saridegib Plus Gemcitabine in Patients with Metastatic Pancreatic Cancer
Infinity Pharmaceuticals, Inc. announced interim data from its double-blind, randomized, placebo-controlled Phase II study comparing saridegib in combination with gemcitabine to placebo plus gemcitabine in 122 patients with previously untreated, metastatic pancreatic cancer. [Infinity Pharmaceuticals, Inc.]
Press Release

National Institutes of Health (United States)

Food and Drug Administration (United States)
 
Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

National Health Service (United Kingdom)

Therapeutic Goods Administration (Australia)

NEW Drug Discovery World Asia
March 19-22, 2012
Singapore, Singapore

NEW Gordon Research Conference: DNA Damage, Mutation & Cancer
March 25-30, 2012
Ventura, United States

Visit our events page to see a complete list of events in the pancreatic cell community.

Research and Development Technologist, hPSC Media (STEMCELL Technologies) 

Scientist – Pluripotent Stem Cells (STEMCELL Technologies)

Scientific Marketing Communications Specialist (STEMCELL Technologies)

Research Technologist, Manufacturing Sciences (STEMCELL Technologies)

Business Analyst – Product Management (STEMSOFT Software)

Postdoctoral Associate for Diabetes Research (Sanford Burnham Medical Research Institute)

Associate Professor – Stem Cell Biology and Diabetes (McEwen Centre for Regenerative Medicine)


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