The PACAP-Regulated Gene Selenoprotein T Is Abundantly Expressed in Mouse and Human Beta Cells and Its Targeted Inactivation Impairs Glucose Tolerance To elucidate the role of Selenoprotein T (SelT) in ß-cells, investigators generated, using a Cre-Lox strategy, a conditional pancreatic ß-cell SelT knockout C57BL/6J mice (SelT-insKO) in which SelT gene disruption is under the control of the rat insulin promoter Cre gene. Glucose administration revealed that male SelT-insKO mice display impaired glucose tolerance. [Endocrinology] Abstract Macrophage-Secreted Cytokines Drive Pancreatic Acinar-to-Ductal Metaplasia through NF-?B and MMPs Researchers found that both RANTES and tumor necrosis factor a induce acinar-to-ductal metaplasia through activation of nuclear factor ?B (NF-?B) and its target genes involved in regulating survival, proliferation, and degradation of extracellular matrix. [J Cell Biol] Abstract | Press Release GPR40 Protein Levels Are Crucial to the Regulation of Stimulated Hormone Secretion in Pancreatic Islets. Lessons from Spontaneous Obesity-Prone and Non-Obese Type 2 Diabetes in Rats Scientists explored the influence of GPR40 protein levels on hormone secretion in islets from two rat models of spontaneous type 2 diabetes displaying either hyperlipidemia or hyperglycemia. [Mol Cell Endocrinol] Abstract Pancreatic Islet Differentiation of Human Embryonic Stem Cells by MicroRNA Overexpression Human embryonic stem cells were transduced with lentiviral vectors containing human microRNA (miR)-375 precursor and aggregated to form human embryoid bodies (hEBs) for up to 21 days. Morphological assessment, immunocytochemistry and DTZ staining confirmed that miR-375-induced hEBs have similar characteristics to those of mature islets. [J Tissue Eng Regen Med] Abstract Cocoa Phenolic Extract Protects Pancreatic Beta Cells against Oxidative Stress Researchers investigated the chemo-protective effect of a cocoa phenolic extract containing mainly flavonoids against oxidative stress induced by tert-butylhydroperoxide on Ins-1E pancreatic beta cells. [Nutrients] Abstract | Full Article PANCREATIC CANCER Early Epigenetic Downregulation of WNK2 Kinase during Pancreatic Ductal Adenocarcinoma Development Pancreatic ductal adenocarcinoma (PDAC) is usually incurable. Contrary to genetic mechanisms involved in PDAC pathogenesis, epigenetic alterations are ill defined. Here, scientists determined the contribution of epigenetically silenced genes to the development of PDAC. [Oncogene] Abstract Protease Activated Receptor-2 Induces Migration of Pancreatic Cancer Cells in an Extracellular ATP Dependent Manner Investigators showed that protease-activated receptor 2 does not affect pancreatic cancer cell proliferation but significantly induce migration of pancreatic cancer cells in scratch assays. [J Thromb Hemost] Abstract FGFR3 Has Tumor Suppressor Properties in Cells with Epithelial Phenotype FGFR3 expression was forced in pancreatic cell lines. The receptor exerted dual effects: it suppressed tumor growth in pancreatic epithelial-like cells and had oncogenic properties in pancreatic mesenchymal-like cells. [Mol Cancer] Abstract | Full Article S100A4 mRNA Expression Level Is a Predictor of Radioresistance of Pancreatic Cancer Cells Improving poor outcomes in patients with pancreatic cancer requires a greater understanding of the biological mechanisms contributing to radioresistance. Scientists, therefore, sought to identify genes involved in the radioresistance of pancreatic cancer cells. [Oncol Rep] Abstract SOX2 Promotes Dedifferentiation and Imparts Stem Cell-Like Features to Pancreatic Cancer Cells Researchers show that Sex-determining region Y-Box2 (SOX2) is not expressed in normal pancreatic acinar or ductal cells. However, ectopic expression of SOX2 is observed in 19.3% of human pancreatic tumors. [Oncogenesis] Full Article |