DIABETES & PANCREATITIS Increased Glucose Metabolism and Glycerolipid Formation by Fatty Acids and GPR40 Underlies the Fatty Acid Potentiation of Insulin Secretion Researchers assessed the effect of fatty acids on the dynamics of the metabolome in INS-1 cells following exposure to U-[13C]glucose to assess flux through metabolic pathways. [J Biol Chem] Abstract | Full Article Bone Marrow Mesenchymal Stem Cells Promote the Repair of Islets from Diabetic Mice through Paracrine Actions Scientists tested the cytoprotective effect of conditioned medium from cultured mesenchymal stem cells on isolated islets exposed to STZ in vitro and on mice islets after the experimental induction of diabetes in vivo. [Mol Cell Endocrinol] Abstract Increased DNase I Activity in Diabetes Might Be Associated with Injury of Pancreas With blood samples from a previous study related to type 2 diabetes, researchers examined the DNase I activity in the serum of these patients and the role of DNase I in the injury of pancreas was further investigated in rats and INS-1 cells. [Mol Cell Biochem] Abstract The Furan Fatty Acid Metabolite CMPF Is Elevated in Diabetes and Induces ß Cell Dysfunction The authors showed that 3-carboxy-4-methyl-5-propyl-2-furanpropanoic acid (CMPF) acts directly on ß cells, causing impaired mitochondrial function, decreasing glucose-induced ATP accumulation, and inducing oxidative stress, resulting in dysregulation of key transcription factors and ultimately reduced insulin biosynthesis. [Cell Metab] Full Article PANCREATIC CANCER Differential Activity of GSK-3 Isoforms Regulates NF-?B and TRAIL- or TNFa Induced Apoptosis in Pancreatic Cancer Cells Scientists report that TRAIL-induced apoptosis in pancreatic ductal adenocarcinoma cell lines is enhanced by pharmacological inhibition of glycogen synthase kinase-3 (GSK-3) or by short hairpin RNA-mediated depletion of either GSK-3a or GSK-3ß. [Cell Death Dis] Full Article Inflammation and Pancreatic Cancer: Molecular and Functional Interactions between S100A8, S100A9, NT-S100A8 and TGFbeta1 In order to gain further insight on the crosstalk between pancreatic ductal adenocarcinoma (PDAC) and stromal cells, researchers investigated interactions occurring between TGFbeta1 and the inflammatory proteins S100A8, S100A9 and NT-S100A8, a PDAC-associated S100A8 derived peptide, in cell signaling, intracellular calcium and epithelial to mesenchymal transition. [Cell Commun Signal] Abstract | Full Article Insulin-Like Growth Factor 1 Receptor (IGF-1R) as a Target of MiR-497 and Plasma IGF-1R Levels Associated with TNM Stage of Pancreatic Cancer Upregulation of miR-497 in BxPC-3 and AsPC-1 pancreatic cancer cell lines inhibited proliferation, enhanced apoptosis, re-sensitized cells to gemcitabine and suppressed insulin-like growth factor 1 receptor (IGF-1R) and p-AKT expression through direct downregulation of IGF-1R protein expression. [PLoS One] Full Article Combination of Dasatinib and Gemcitabine Reduces the ALDH1A1 Expression and the Proliferation of Gemcitabine-Resistant Pancreatic Cancer MIA PaCa-2 Cells Scientists investigated the effectiveness of dasatinib, an SRC inhibitor, and gemcitabine combination to inhibit the survivals of parental and gemcitabine-resistant cell lines. [Int J Oncol] Abstract Upregulation of the Splice Variant MUC4/Y in the Pancreatic Cancer Cell Line MIA PaCa-2 Potentiates Proliferation and Suppresses Apoptosis: New Insight into the Presence of the Transcript Variant of MUC4 Scientists investigated the specific function of MUC4/Y. The pancreatic cancer cell line MIA PaCa-2 with low MUC4/Y expression was used to establish a stable cell model of MUC4/Y upregulation using a lentivirus vector system. [Oncol Rep] Abstract |