DIABETES & PANCREATITIS Preferential Gene Expression and Epigenetic Memory of Induced Pluripotent Stem Cells Derived from Mouse Pancreas Scientists established induced pluripotent stem cells (iPSC) derived from mouse pancreas (Panc-iPSC) and compared their properties with those of iPSC derived from tail-tip fibroblast (TTF-iPSC). The metabolic profile differs between Panc-iPSC and TTF-iPSC, indicating distinct cell properties in these iPSCs. [Genes Cells] Abstract Inwardly Rectifying Kir2.1 Currents in Human β-Cells Control Electrical Activity: Characterization and Mathematical Modelling The Kir2.1 potassium channels gene is expressed in human pancreatic islets, and scientists show that functional Kir2.1 currents are present in human β-cells. They characterized the human Kir2.1 β-cell current, and included it in a recent mathematical model of electrical activity in human β-cells. [Biochem Biophys Res Commun] Abstract Differential Gene Expression in GPR40-Overexpressing Pancreatic β-Cells Treated with Linoleic Acid Researchers examined the profiles of differential gene expression in G protein-coupled receptor 40 (GPR40)-activated cells treated with linoleic acid, and finally predicted the integral pathways of the cellular mechanism of GPR40-mediated insulinotropic effects. After constructing a GPR40-overexpressing stable cell line from the rat pancreatic β-cell line RIN-5f, they determined the gene expression profiles of RIN-5f and RIN-40. [Korean J Physiol Pharmacol] Full Article PANCREATIC CANCER Manganoporphyrins and Ascorbate Enhance Gemcitabine Cytotoxicity in Pancreatic Cancer Scientists hypothesized that combining manganoporphyrins and pharmacological ascorbate with the chemotherapeutic agent gemcitabine would further enhance pancreatic cancer cell cytotoxicity without increasing toxicity in normal pancreatic cells or other organs. [Free Radic Biol Med] Abstract Kindlin-2 Induced by TGF-β Signaling Promotes Pancreatic Ductal Adenocarcinoma Progression through Downregulation of Transcriptional Factor HOXB9 Scientists found that Kindlin-2 is a target protein of transforming growth factor β (TGF-β) signaling and is upregulated by TGF-β1 in pancreatic ductal adenocarcinoma (PDAC) cells. TGF-β1-upregulated Kindlin-2 promotes PDAC cell growth, migration and invasion, whereas Kindlin-2 upregulates transforming growth factor receptor I, a key component of TGF-β signaling. [Cancer Lett] Abstract hERG1 Channels Drive Tumor Malignancy and May Serve as Prognostic Factor in Pancreatic Ductal Adenocarcinoma The functional role of hERG1 was studied in pancreatic ductal adenocarcinoma (PDAC) cell lines and primary cultures. hERG1 blockade decreased PDAC cell growth and migration. [Br J Cancer] Abstract Apoptosis and Anergy of T Cell Induced by Pancreatic Stellate Cells-Derived Galectin-1 in Pancreatic Cancer Researchers investigated the relationship between pancreatic stellate cells (PSC)-derived galectin-1 and tumor immunity in pancreatic cancer. Isolated PSCs were identified as normal pancreas cells or pancreatic cancer cells by immunohistochemical staining for α-SMA and vimentin, and galectin-1 expression was evaluated by Western blotting and quantitative RT-PCR. [Tumor Biol] Abstract Pancreatic Adenocarcinoma Upregulated Factor (PAUF) Confers Resistance to Pancreatic Cancer Cells against Oncolytic Parvovirus H-1 Infection through IFNA Receptor-Mediated Signaling Panc-1 cells expressing PAUF (Panc-PAUF) showed relative resistance to parvovirus H-1 infection compared with Panc-1 cells expressing an empty vector (Panc-Vec). Expression of type I IFN-α receptor was higher in Panc-PAUF cells than in Panc-Vec cells. [Biochem Biophys Res Commun] Abstract |