Pancreatic Cell News 7.28 July 19, 2016 | |
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TOP STORYScientists investigated the role of prorenin receptor (PRR) in pancreatic tumorigenesis and assessed whether PRR can serve as a target for imaging diagnosis at early stages of pancreatic ductal adenocarcinoma. [Oncotarget] Full Article | |
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PUBLICATIONS(Ranked by impact factor of the journal)DIABETES & PANCREATITISInvestigators evaluated the roles of CB2R agonist, GW405833 (GW) in agonist-induced Ca2+ oscillations in pancreatic acinar cells using multiple experimental approaches with acute dissociated pancreatic acinar cells prepared from wild type, CB1R-knockout (KO), and CB2R-KO mice. [Sci Rep] Full Article Investigators aimed to understand the downstream inflammatory signaling involved in progression of chronic pancreatitis, and to use withaferin A, a small molecule inhibitor of nuclear factor κB (NFκB), to prevent progression of chronic pancreatitis. [J Gastroenterol] Abstract Researchers dynamically profiled nerve growth factor (NGF) secretion from islets and used selective trkA and p75NTR inhibitors to identify the role of endogenous NGF in β-cell stimulus-secretion coupling. [Mol Cell Endocrinol] Abstract Prolonged Insulin Treatment Sensitizes Apoptosis Pathways in Pancreatic Beta Cells Researchers investigated the mechanism underlying the cycle of hyperglycemia and hyperinsulinemia eventually leading to pancreatic β cell deterioration and death. [J Endocrinol] Abstract PANCREATIC CANCERIt was reported that extracellular Annexin A1 (ANXA1) mediates pancreatic cancer (PC) cell motility acting on formyl peptide receptors. Researchers describe other mechanisms by which intracellular ANXA1 could mediate PC progression. [Sci Rep] Full Article Researchers found that GPRC5A is part of a complex molecular axis that involves gemcitabine and HuR, and, possibly, other genes. [Cell Death Dis] Full Article Selective GPR55 Antagonism Reduces Chemoresistance in Cancer Cells Researchers investigated the anti-tumorigenic effect of (R,R’)-4′-methoxy-1-naphthylfenoterol in the human pancreatic cancer cell line, PANC-1, by focusing on the expression of known cancer biomarkers and the expression and function of multidrug resistance exporters such as P-glycoprotein and breast cancer resistance protein. [Pharmacol Res] Abstract PROX1 and β-Catenin Are Prognostic Markers in Pancreatic Ductal Adenocarcinoma Scientists investigated PROX1 and β-catenin expression in pancreatic ductal adenocarcinoma. [BMC Cancer] Full Article Scientists analyzed the expression of putative cancer stem cell markers-CD24, CD44, epithelial cell adhesion molecule, CD133, and nestin-by immunofluorescence, flow cytometry and quantitative PCR in three pancreatic ductal adenocarcinoma-derived cell lines and by immunohistochemistry in three corresponding tumor samples. [PLoS One] Full Article | |
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REVIEWSStem Cell Therapy Emerging as the Key Player in Treating Type 1 Diabetes Mellitus The authors describe the history and current knowledge of T1DM, evolution of cell therapies and different cellular therapies to cure this condition. [Cytotherapy] Abstract Visit our reviews page to see a complete list of reviews in the pancreatic cell research field.
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INDUSTRY NEWSPancreatic Cancer Network Awards $2 Million to Wilmot Investigator The national Pancreatic Cancer Action Network granted its most competitive award, for $2 million, to David C. Linehan, M.D., to support a large, multicenter clinical trial testing an immunotherapy in patients with metastatic pancreatic cancer. [University of Rochester] Press Release MabVax Therapeutics Holdings, Inc. announced the initiation of patient enrollment at Memorial Sloan Kettering Cancer Center in a Phase I clinical trial evaluating its new generation diagnostic PET imaging agent, MVT-2163 for patients with locally advanced or metastatic adenocarcinoma of the pancreas or other CA19-9 positive malignancies. [MabVax Therapeutics Holdings, Inc.] Press Release The U.S. Food and Drug Administration has approved an expanded indication for Synjardy® tablets to include treatment-naïve adults with type 2 diabetes (T2D). SYNJARDY is indicated as an adjunct to diet and exercise to improve glycemic control in adults with T2D when treatment with both empagliflozin and metformin is appropriate. [Eli Lilly and Company] Press Release AstraZeneca Receives Approval in the EU for Qtern for Treatment of Type 2 Diabetes AstraZeneca announced that the European Commission has approved Qtern tablets for the treatment of type 2 diabetes in all 28 EU member countries plus Iceland, Liechtenstein and Norway. [AstraZeneca] Press Release | |
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POLICY NEWSA Week of Political Bloodletting, but U.K. Science Minister Keeps His Job For researchers worried about the future of science in the United Kingdom, the news was something to hold onto. Jo Johnson announced he will remain as science minister, despite a massive shakeup of the government cabinet. [ScienceInsider] Editorial
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EVENTSNEW 28Th European Organisation for Research and Treatment of Cancer (EORTC), the National Cancer Institute (NCI) and the American Association for Cancer Research (AACR) Symposium Visit our events page to see a complete list of events in the pancreatic cell community.
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JOB OPPORTUNITIESNEW Postdoctoral Researcher – Breast, Prostate, and Pancreatic Cancer (MD Anderson Cancer Center) NEW Postdoctoral Research Assistant – Pancreatic Cancer (Queen Mary University of London) Research Program Manager – Pancreatic Cancer (University of Cambridge) Postdoctoral Fellow – Pancreatic Cancer Biology (New York University School of Medicine) Principal Investigator – Tenure Track Position (National Institutes of Health) Postdoctoral Fellowship – Various Projects (University of Pittsburgh) Research Fellow – Pancreatic β-Cell Biology and Regeneration (Dresden University of Technology) Postdoctoral Fellow – Pancreatic Cancer Metabolism (Thomas Jefferson University) Postdoctoral Fellows – Various Positions (Oregon Health & Science University) Postdoctoral Fellow – Quantitative Hepato-Pancreatic MR Imaging (Inserm) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
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Home Pancreatic Cell News Volume 7.28 | Jul 19 2016