Pancreatic Cell News 8.38 September 26, 2017 | |
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TOP STORYInvestigators showed that the pancreatic beta-cells in zebrafish exhibit different growth-promoting and functional properties, which in part reflect differences in the time elapsed since birth of the cells. [Nat Commun] Full Article | Press Release | Video | |
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PUBLICATIONS(Ranked by impact factor of the journal)DIABETES & PANCREATITISFumarate Hydratase Deletion in Pancreatic β Cells Leads to Progressive Diabetes Mice lacking Fh1 in pancreatic β cells appeared normal for six-eight weeks but then developed progressive glucose intolerance and diabetes. [Cell Rep] Full Article | Graphical Abstract Fenofibrate effectively improved lipid accumulation in pancreatic β-cells, increased glucose-stimulated insulin secretion and β-cell mass, and significantly downregulated pro-apoptotic molecules, at the gene and protein levels, both in vivo and in vitro. [Metabolism] Abstract The authors explored the effect of a chronic treatment with lipophilic and hydrophilic statins on β-cell function, using human pancreatic islets and rat insulin-secreting INS-1 cells. [Sci Rep] Full Article Late-Stage Differentiation of Embryonic Pancreatic β-Cells Requires Jarid2 Scientists investigated the role of Jarid2 during pancreas development. Conditional ablation of Jarid2 in pancreatic progenitors resulted in reduced endocrine cell area at birth due to impaired endocrine cell differentiation and reduced prenatal proliferation. [Sci Rep] Full Article PANCREATIC CANCERA human PDAC cell line with well-to-moderately differentiated properties was subjected to lectin microarray analysis to identify specific lectin-glycan pairs. The selected lectin was fused with a bacterial exotoxin for the construction of a LDC, and its safety and anti-tumor effects were evaluated. [Mol Cancer Ther] Abstract | Full Article Scientists performed ex vivo pancreatitis studies in human acini isolated from cadaveric pancreata from organ donors. They assessed their functional integrity, and cellular and organellar morphology, using light, fluorescence and electron microscopy, and their proteome by liquid chromatography-tandem mass spectrometry. [Am J Pathol] Abstract A multimodal analysis, including metabolic imaging using hyperpolarized pyruvate, pointed to reduced oxidative flux due to NAD+ depletion after β-lapachone treatment of NAD(P)H:quinone oxidoreductase 1 (NQO1+) human pancreatic cancer cells. [J Biol Chem] Abstract | Full Article Upregulation of the expression of colorectal neoplasia differentially expressed (CRNDE) was found in pancreatic cancer tissues as well as cell lines, in comparison with the adjacent non-tumor tissues and human pancreatic duct epithelial cells. High expression of CRNDE was correlated with poor clinipathological characteristics and shorter overall survival. [Cell Prolif] Abstract | |
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REVIEWSXenoislets: Porcine Pancreatic Islets for the Treatment of Type I Diabetes The authors focus on recent advances in porcine islet transplantation with particular emphasis on new transgenic pig models, islet encapsulation, and biosafety considerations. [Curr Opin Organ Transplant] Abstract Visit our reviews page to see a complete list of reviews in the pancreatic cell research field. | |
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INDUSTRY NEWSSTEMCELL Technologies has signed an exclusive license with Propagenix to commercialize its patented EpiXâ„¢ technology, a novel and revolutionary cell culture medium that enables unprecedented expansion of tissue-resident epithelial stem cells without any genetic manipulation. [STEMCELL Technologies Inc.] Press Release NewLink Genetics Corporation announced that it has entered into a clinical collaboration agreement with AstraZeneca to evaluate the combination of indoximod, NewLink Genetics’ small molecule IDO pathway inhibitor, and durvalumab, AstraZeneca’s anti-PD-L1 monoclonal antibody, along with standard of care chemotherapy for patients with metastatic pancreatic cancer. [NewLink Genetics Corporation] Press Release The Parker Institute for Cancer Immunotherapy and the Cancer Research Institute announced the first patients have begun treatment in a new pancreatic cancer multi-center clinical trial. [Cancer Research Institute] Press Release | |
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POLICY NEWSCanada Names New Chief Science Adviser Mona Nemer, a cardiology researcher and vice-president of research at the University of Ottawa, has been named Canada’s new Chief Science Adviser by Prime Minister Justin Trudeau. [ScienceInsider] Editorial What Germany’s Election Results Mean for Science As Germany reels from an unexpected surge for the far right in the elections, researchers don’t expect much effect on the country’s generous support for science. But with smaller parties standing to gain political influence, battles over issues such as the regulation of gene-edited organisms and how to cut greenhouse-gas emissions could grow fiercer. [Nature News] Editorial BIA & MHRA Publish Report ‘Innovation in Life Sciences in a Changing and Dynamic Environment’ The UK BioIndustry Association (BIA) and the Medicines and Healthcare Products Regulatory Agency (MHRA) brought together experts from across the sector to discuss some hot topics and important developments that are having an impact on the changing and dynamic UK life sciences ecosystem. [Medicines and Healthcare Products Regulatory Agency] Press Release United Kingdom Sees Dip in European Research Applications after Brexit Vote The number of researchers applying for Europe-funded Marie Curie fellowships in the United Kingdom has dipped slightly since the country’s vote to leave the European Union, data released to Nature show. But there is no evidence yet of a sharp collapse in interest, which some scientists had feared in the wake of the Brexit referendum. [Nature News] Editorial HHMI’s Own Brand of Diversity in the Life Sciences One of Erin O’Shea’s first moves as Howard Hughes Medical Institute (HHMI) president was committing $25 million a year to support postdocs from underrepresented groups. Her hope was that they would eventually change the color—and culture—of their departments as they moved into leadership positions, in addition to serving as role models for the next generation of scientists. [ScienceInsider] Editorial
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EVENTSNEW Keystone Symposia: Endoderm Development and Disease: Cross-Organ Comparison and Interplay Visit our events page to see a complete list of events in the community.
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JOB OPPORTUNITIESNEW Professor – Immunomodulation (Ludwig-Maximilians-Universität München) Researcher – Cancer Biology (University of Cincinnati) Postdoctoral Fellow – Diabetes (Harvard University) Postdoctoral Research Fellow – RNA Metabolism in Pancreatic Cancer (Moffitt Cancer Center) Postdoctoral Research Position – Pancreatitis and Pancreatic Cancer (Stanford University) Faculty Position – Cancer Biology (The University of Texas Southwestern) Postdoctoral Research Scientist – Tumor Environment (Cancer Research UK Beatson Institute) Postdoctoral Position – Islet Biology (Sanofi) Postdoctoral Scientist – hPSC Differentiation into Beta Cells (Helmholtz Zentrum München) Scientist – Diabetes and Obesity (Helmholtz Zentrum München) Assistant Investigator – Cancer Genetics, Epigenetics and Biomarkers (Baylor Research Institute) Postdoctoral Fellow – Cancer Genetics, Epigenetics and Biomarkers (Baylor Research Institute) Research Assistant – Cancer Genetics, Epigenetics and Biomarkers (Baylor Research Institute) Postdoctoral Scholar – Pancreatic and Lung Cancer Research (University of California, San Francisco) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
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