Pancreatic Cell News 8.43 October 31, 2017 | |
| |
TOP STORYSmart Artificial Beta Cells Could Lead to New Diabetes Treatment Researchers developed artificial cells that automatically release insulin into the bloodstream when glucose levels rise. These “artificial beta cells” mimic the functions of the body’s natural glucose-controllers, the insulin-secreting beta cells of the pancreas. [Press release from the University of North Carolina discussing online prepublication in Nature Chemical Biology] Press Release | Abstract | |
| |
PUBLICATIONS(Ranked by impact factor of the journal)DIABETES & PANCREATITISInduced pluripotent stem cells (iPSCs) derived from pancreatic beta cells (BiPSCs) preferentially differentiated toward endocrine pancreas-like cells versus those from fibroblasts (FiPSCs). Scientists interrogated genome-wide open chromatin in BiPSCs and FiPSCs via ATAC-seq and identified ∼8.3k significant, differential open chromatin sites between the two iPSC subtypes. [Stem Cell Reports] Full Article miR-629 Promotes Human Pancreatic Cancer Progression by Targeting FOXO3 The authors found that overexpressing and inhibiting miR-629, respectively, enhanced and reduced the cell proliferation and metastasis of pancreatic cancer cells in vitro and in vivo compared with parental cells or cells transfected with a control vector. [Cell Death Dis] Full Article Researchers investigated miR-204 expression in pancreatic endocrine tumors, a panel of human tissues, tissues derived from pancreatic islet purification, and in induced pluripotent stem cells differentiated towards a pancreatic endocrine phenotype by quantitative real time RT-PCR or droplet digital PCR. [Sci Rep] Full Article Scientists investigated the role of intracellular sphingosine-1 phosphate (S1P) in insulin-secreting INS1E cells by genetically manipulating the S1P-metabolizing enzyme S1P lyase. [J Biol Chem] Abstract | Full Article Investigators explored the specific effect of resveratrol on porcine pancreatic stem cells (PSCs). They treated porcine PSCs with 10 μM, 25 μM resveratrol to explore the effect of resveratrol on porcine PSC. [PLoS One] Full Article PANCREATIC CANCERmiR-92b-3p Acts as a Tumor Suppressor by Targeting Gabra3 in Pancreatic Cancer The authors provide evidence that miR-92b-3p acted as a tumor suppressor in pancreatic cancer (PC) by regulating Gabra3 expression. miR-92b-3p overexpression suppressed the proliferation and invasion of PC cells in both in vivo and in vitro models. [Mol Cancer] Full Article Researchers investigated whether calreticulin promotes EGF-induced epithelial–mesenchymal transition (EMT) in pancreatic cancer (PC) via integrin/EGFR-ERK/MAPK signaling. EGF simultaneously induced EMT and activated integrin/EGFR–ERK/MAPK signaling pathway in three PC cells. [Cell Death Dis] Full Article Investigators report that platelets regulated the expression of human equilibrative nucleoside transporter 1 and cytidine deaminase, markers of gemcitabine resistance in pancreatic cancer. [Cancers] Full Article The authors demonstrated that fibroblast activation protein (FAP) overexpression in the tumor microenvironment correlates with poor overall and disease-free survival of pancreatic ductal adenocarcinoma (PDA) patients. Genetic deletion of FAP delayed onset of primary tumor and prolonged survival of mice in the KPC mouse model of PDA. [JCI Insight] Full Article | Press Release | |
| |
REVIEWSLysine Methylation Signaling in Pancreatic Cancer Scientists discuss the potential impact of epigenetic therapies, focusing on lysine methylation signaling and its implication in pancreatic cancer. [Curr Opin Oncol] Abstract Visit our reviews page to see a complete list of reviews in the pancreatic cell research field. | |
| |
SCIENCE NEWSSyros’ Drug Discovery Research in Immuno-Oncology Highlighted in Oral Presentation Syros Pharmaceuticals announced that it has identified alterations in regulatory regions of the genome in immune, tumor and stromal cells isolated from pancreatic cancer patient tumors, leading to the identification of new drug targets. [Press release from Syros Pharmaceuticals discussing research presented at American College of Surgeons (ACS) 2017 Clinical Congress, San Diego] Press Release | |
| |
INDUSTRY NEWSUC San Diego Health Researchers Help Launch Second Pancreas Cancer “Dream Team” Scientists and physicians at Moores Cancer Center at Univesity of California, San Diego Health, in partnership with colleagues at MD Anderson Cancer Center in Texas, Johns Hopkins University in Maryland and elsewhere, have been awarded a $7 million grant over four years by Stand Up To Cancer to create a “dream team” to develop new ways to prevent pancreatic cancer. [Univesity of California, San Diego] Press Release Minneamrita announced that an IND application to the FDA for a Phase I trial of an oral formulation of the company’s Minnelide for patients with advanced cancers is now active. [Minneamrita Therapeutics LLC (Business Wire, Inc.)] Press Release | |
| |
POLICY NEWSSix Papers by Disgraced Surgeon Should Be Retracted, Report Concludes Sweden’s national scientific ethics board, the Expert Group on Misconduct in Research, has concluded that six papers authored by disgraced surgeon Paolo Macchiarini should be retracted. The papers describe the purported clinical success of artificial trachea “seeded” with a patient’s own stem cells. All three patients described in the papers died of complications related to the implant. [ScienceInsider] Editorial Spanish Government Takes Control of Catalonian Universities The Spanish government has taken over responsibility for higher education and research in Catalonia, following the region’s unilateral declaration of independence. It will retain control of spending on research centres and universities, which the League of European Research Universities says threatens institutional autonomy. [Nature News] Editorial US March for Science Group Faces Growing Pains The US group that sparked the global March for Science movement is facing complaints about its management practices as it files for non-profit status and signals its intent to continue as “a movement to advance science and its role in public life”. [Nature News] Editorial
| |
EVENTSNEW The 2018 World Stem Cell Summit (WSCS) Visit our events page to see a complete list of events in the community.
| |
JOB OPPORTUNITIESNEW Postdoctoral Position – Pancreatic Cancer (Translational Genomics Research Institute) NEW Assistant Professor – Cancer Biology (Perelman School of Medicine) PhD Studentships – Cancer Research (University of Cambridge) Research Fellow – Pancreatic Cancer (Memorial Sloan Kettering Cancer Center) Postdoctoral Position – Pancreatic Cancer (University of California, San Francisco) Faculty Positions – Cancer Research (Huntsman Cancer Institute) Researcher – Cancer Biology (University of Cincinnati) Postdoctoral Fellow – Diabetes (Harvard University) Scientist – Diabetes and Obesity (Helmholtz Zentrum München) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
| |
Have we missed an important article or publication in Pancreatic Cell News? Click here to submit! Comments or suggestions? Submit your feedback here. | |
|