Pancreatic Cell News 9.18 May 8, 2018 | |
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TOP STORYResearchers identified the previously uncharacterized gene SSTR5-AS1 and showed that it plays an important role in controlling the effect of somatostatin-28 on insulin secretion. [Proc Natl Acad Sci USA] Abstract | |
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PUBLICATIONS(Ranked by impact factor of the journal)DIABETES & PANCREATITISScientists reported the successful adaptation of a previously developed method for generating complex tissues from diverse tissue fragments derived from various organs, including pancreatic islets. [Cell Rep] Full Article | Press Release | Graphical Abstract Researchers evaluated the expression of the key antioxidant enzymes in β- and alpha(α)-cells and accessed the effects of oxidative stress, islet isolation and transplantation on β/α-cell ratio and viability in human islets. [PLoS One] Full Article Treatment of primary islets with a protease-activated receptor 2 (PAR2) agonist in combination with inhibitors of insulin secretion and signaling was sufficient to induce insulin and PAX4 gene expression. In primary human islets, this treatment also led to the induction of bihormonal islet cells coexpressing glucagon and insulin, a hallmark of islet cell transdifferentiation. [Islets] Abstract Pancreatic Beta-Cell Proliferation Induced by Estradiol-17β is Foxo1 Dependent Using human islets and the INS1-E β-cell line, the authors investigated the contribution of Foxo1 to estradiol-17β (E2)-mediated β-cell replication. In human islets, inhibition of Foxo1 abrogated E2-mediated proliferation and attenuated the response to the ERα agonist PPT. [Horm Metab Res] Abstract PANCREATIC CANCERInvestigators revealed that macrophages are the dominant leukocyte population both in human pancreatic ductal adenocarcinoma (PDAC) stroma and autochthonous models, with an important functional contribution to the squamous subtype of human PDAC. [Cell Rep] Full Article | Graphical Abstract Scientists used selected pancreatic ductal adenocarcinoma (PDAC) tumor samples and PDAC cell lines together with small interfering RNA technology to study the role of myoferlin in energetic metabolism. [Oncogene] Full Article Researchers discovered that inherent differences in eIF2α phosphorylation among a panel of ten human pancreatic cancer cell lines significantly impacts bortezomib sensitivity, and implicate the heme-regulated inhibitor (HRI) eIF2α kinase as a novel therapeutic target. [Oncogene] Abstract Scientists tested whether induced MIST1 or PTF1a expression in pancreatic ductal adenocarcinoma cells could re‐establish the transcriptional program of differentiated acinar cells and simultaneously reduce tumor cell properties. [Mol Oncol] Abstract | Full Article Bitter melon juice effects were associated with a decrease in the expression of genes and proteins involved in pancreatic cancer‐associated cancer stem cells renewal and proliferation. [Mol Carcinog] Abstract The authors evaluated retroviral replicating vector (RRV)-mediated prodrug activator gene therapy as a new therapeutic approach for pancreatic ductal adenocarcinoma (PDAC). RRV spread rapidly and conferred significant cytotoxicity with prodrug in a panel of PDAC cells. [Cancer Gene Ther] Abstract | |
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REVIEWSGlucagon-Like Peptide 1 in Health and Disease The authors provide insights into the physiology of glucagon-like peptide 1 (GLP1) and its involvement in the pathophysiology of type 2 diabetes mellitus and an overview of the currently available and emerging GLP1 receptor agonists. [Nat Rev Endocrinol] Abstract Therapeutic Developments in Pancreatic Cancer: Current and Future Perspectives Investigators address the questions of how we should approach the development of pancreatic cancer treatments, including those for patients with metastatic, locally advanced and borderline resectable pancreatic cancer, as well as for patients with resected tumors. [Nat Rev Gastroenterol Hepatol] Abstract Visit our reviews page to see a complete list of reviews in the pancreatic cell research field. | |
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INDUSTRY NEWSGovernment of Canada and JDRF Invest $7.7M in Type 1 Diabetes Care and Treatments Sonia Sidhu, Member of Parliament for Brampton South, and Chair of the All-Party Caucus on Diabetes, on behalf of the Honourable Ginette Petitpas Taylor, Minister of Health, highlighted an investment of $7.7M in type 1 diabetes research. [JDRF] Press Release JDRF announces the awarding of a research grant to International Diabetes Center in Minneapolis. The two-year $525,000 grant will be used to fund the study of intranasal insulin use by individuals with long-standing type 1 diabetes who have significantly impaired ability to sense low blood sugar, medically referred to as hypoglycemia unawareness. [HealthPartners] Press Release | |
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POLICY NEWSCancer-Killing Viruses Show Promise – and Draw Billion-Dollar Investment Pharmaceutical giant Johnson & Johnson announced that it would pay up to US$1 billion to acquire a company that makes cancer-killing viruses. It was a striking show of support for a still-unproven treatment, but the bid is just the latest sign that industry and academics are warming to the approach. [Nature News] Editorial Postdoc Hopes Pennsylvania Voters Will Help Her Re-Engineer How to Run for Congress A postdoctoral researcher at the University of Pennsylvania who designs proteins for possible use in treating cancer, Molly Sheehan has ignored conventional wisdom about the importance of raising tons of money to spread her message that she’s “a mother, a bioengineer, [and a] proud progressive.” Instead, she’s urging scientists and others in the community to offer their considerable skills to work for candidates they support. [ScienceInsider] Editorial Basic Scientists Still Feel Pinch of New NIH Clinical Trial Policy Basic researchers who study the brain and human behavior thought lawmakers had come to their rescue in March by blocking the National Institutes of Health (NIH) from redefining their studies as clinical trials. But NIH officials are still pushing ahead with new requirements that scientists say make no sense and will cripple their research. [ScienceInsider] Editorial Petition Asks National Academy of Sciences to Boot Sexual Harassers An online petition calling on the National Academy of Sciences to revoke memberships bestowed on people sanctioned for sexual harassment has garnered more than 250 signatures since it was posted on May 1. [The Scientist] Editorial Big UK Science Funder Says Report Harassment or Risk Losing Funding One of the world’s largest research-funding charities is cracking down on harassment and bullying. Scientists who have been sanctioned by their institutions could lose out on funding from the Wellcome Trust, under rules announced. [Nature News] Editorial Nature Announces New Editor-in-Chief Nature has named Magdalena Skipper as its new editor-in-chief. She is the first woman to hold the post. Skipper, who is currently editor-in-chief of the open-access journal Nature Communications, will become the eighth editor of Nature. [Nature News] Editorial
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EVENTSNEW Pancreatic Cancer: Advances in Science and Clinical Care Visit our events page to see a complete list of events in the community.
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JOB OPPORTUNITIESNEW EBPOD Fellowship – Pancreatic Cancer Analysis (European Molecular Biology Laboratory) NEW Postdoctoral Positions – Immunology of Diabetes (Cochin Institute) NEW Postdoctoral Position – Functional Genomics of Insulin Resistance (Stanford University) NEW Postdoctoral Fellows – Diabetes Complications & Epigenetics (St. Michael’s Hospital) Doctoral Thesis Positions – Diabetes Research (International Helmholtz Research School for Diabetes) Postdoctoral Fellow – Molecular Medicine (City of Hope) Doctoral Thesis Position – Endocrine Cell Research (Helmholtz Zentrum Munchen) Doctoral Thesis Position – Diabetes Research (Universite Libre de Bruxelles) Postdoctoral Fellow – Genetic Epidemiology of Metabolic Disease (University of Cambridge) Postdoctoral Fellow – Pancreatic Cancer Research (Univeristy of South Wales) Research Fellow/Associate – Diabetes Research (Rutgers University) Postdoctoral Scholar – Cancer (University of California, San Francisco) Postdoctoral Position – Protein Biochemistry (Vlaams Instituut voor Biotechnologie) Postdoctoral Fellow – Epigenetic Regulation of Pancreatic Beta-Cell Mass (City of Hope) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
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