Pancreatic Cell News 9.31 August 7, 2018 | |
| |
TOP STORYHNF1A Is a Novel Oncogene That Regulates Human Pancreatic Cancer Stem Cell Properties Levels of HNF1A and its target genes were found to be elevated in pancreatic cancer stem cells (PCSCs) and tumorspheres, and depletion of HNF1A resulted in growth inhibition, apoptosis, impaired tumorsphere formation, decreased PCSC marker expression, and downregulation of POU5F1/OCT4 expression. [Elife] Abstract | |
| |
PUBLICATIONS(Ranked by impact factor of the journal)DIABETES & PANCREATITISResearchers indicated that coxsackie and adenovirus receptor (CAR)-SIV was the principal isoform in islets and was localized mainly within the cytoplasm of beta cells, rather than at the plasma membrane. They revealed significant co-localisation of CAR-SIV with zinc transporter protein 8, prohormone convertase 1/3 and insulin, but not proinsulin. [Diabetologia] Full Article Vitamin D receptor (Vdr) mRNA was abundant in islets and Vdr expression was glucose-responsive. Preincubation of mouse and human islets with 1,25-dihydroxyvitamin-D3 enhanced glucose-stimulated insulin secretion and increased glucose-stimulated calcium influx. [J Steroid Biochem Mol Biol] Abstract | Graphical Abstract PANCREATIC CANCERScientists indicated that miR-224 inversely regulated thioredoxin-interacting protein (TXNIP) by binding directly to its 3′-untranslated region, which resulted in the activation of hypoxia-inducible factor 1α (HIF1α). Either TXNIP re-expression or HIF1α depletion abolished the effects of miR-224 on the proliferation and migration of pancreatic ductal adenocarcinoma cells in vitro and in vivo. [Cell Physiol Biochem] Full Article In contrast to the tumor-suppressor effect of the mammalian STE20-like protein kinase 1 (MST1)-MOB kinase activator 1 (MOB1) complex, the MST4-MOB4 complex promoted growth and migration of PANC-1 cells. Expression levels of MST4 and MOB4 were elevated in pancreatic cancer and were positively correlated with each other, whereas MST1 expression was down-regulated. [J Biol Chem] Abstract | Full Article The activation of intrinsic apoptosis and G1 phase arrest resulting from mitochondria damage caused by SZC015 contributed significantly to the anticancer effects of SZC015. SZC015 also had remarkably inhibitory effects on transcription factors that are extensively activated in pancreatic cancer tissues. [J Cell Physiol] Abstract Bergamottin was found to induce cell shrinkage, membrane blebbing, and disintegration of organelles in PANC-1 cells. Bergamottin was also found to inhibit PANC-1 cell migration and colony formation. Mechanistically, bergamottin inhibited key survival proteins in the Akt/mTOR signaling pathway. [J Nat Prod] Abstract | Graphical Abstract Investigators developed Apra S10 as an anti-pancreatic cancer agent which potently inhibited the growth of both established and patient-derived primary pancreatic cancer cells. They validated its mechanism of action on pancreatic cancer cells by demonstrating the downregulation of multiple receptor tyrosine kinases and inhibition of growth factor and cytokine secretion. [Invest New Drugs] Abstract After seven days in culture, CTC from pancreatic ductal adenocarcinoma (PDAC), cholangiocarcinoma (CC), and ampullary adenocarcinoma (AA) patients recruited multiple immune cell types, including CD105 + CD14 + myeloid fibroblasts, to organize into spheroid-like clusters. [Cancer Biol Ther] Abstract ERO1L Promotes Pancreatic Cancer Cell Progression through Activating the Wnt/Catenin Pathway Researchers suggested that endoplasmic reticulum oxidoreductase 1 alpha (ERO1L) promoted many tumor-associated signaling pathways, especially the Wnt/catenin pathway; it could activate the Wnt/catenin pathway and upregulate the targets of the Wnt/catenin pathway. [J Cell Biochem] Abstract Subscribe to one of our other 19 science newsletters such as Hepatic Cell News & Intestinal Cell News. | |
| |
REVIEWSMitochondria as a Target of Endocrine-Disrupting Chemicals: Implications for Type 2 Diabetes The authors review the main mechanisms whereby metabolism-disrupting chemical, a subclass of endocrine-disrupting chemicals that disturbs energy homeostasis, cause mitochondrial dysfunction, thus contributing to the establishment of insulin resistance and type 2 diabetes. [J Endocrinol] Abstract | Full Article Defining Lipid Mediators of Insulin Resistance – Controversies and Challenges Investigators summarize the evidence linking specific lipid molecules to the induction of insulin resistance, describing some of the current controversies and challenges for future studies in this field. [J Mol Endocrinol] Abstract | Full Article Visit our reviews page to see a complete list of reviews in the pancreatic cell research field. | |
| |
INDUSTRY NEWSThe Janssen Pharmaceutical Companies of Johnson & Johnson announced that the Committee for Medicinal Products for Human Use (CHMP), of the European Medicines Agency, has issued a positive opinion to update the INVOKANA® and VOKANAMET® labeling including changes to the indication statement for the treatment of adults with insufficiently controlled type 2 diabetes mellitus as an adjunct to diet and exercise. [Janssen Global Services, LLC (Business Wire, Inc.)] Press Release Immunovia AB announced that the Karolinska Institute is to participate in PanFAM-1, the largest ever prospective study looking at early diagnosis in high-risk individuals with Familial Pancreatic Cancer. [Immunovia] Press Release The Blavatnik Family Fellowship Fund at the Stanford University School of Medicine will support PhD fellowships that allow young scientists enrolled in the Stanford Biosciences to pursue investigative directions that inspire their creativity and passion. [Stanford University] Press Release | |
| |
POLICY NEWSU.K. Commits to Adopt EU Trial Regulation, Minimize Divergence after Brexit The U.K. regulatory agency has detailed how it expects Brexit to affect its clinical trial regulations. Officials reiterated their intent for the U.K. to implement the incoming European Union Clinical Trials Regulation and expanded on the long-term effects of Brexit on research approval processes. [GOV.UK (Fierce Biotech)] Editorial Japanese University Investigates Claim that It Downgraded Female Test Scores A prominent Japanese medical school is investigating reports that staff allegedly altered test scores to reduce the number of female students accepted onto its degree course. [Nature News] Editorial Australian Universities Condemn Romantic Supervisor-Student Relationships Academics should be removed from their supervisory, teaching or assessment roles if they develop a romantic relationship with one of their students, say organizations that represent Australian universities and students. [Nature News] Editorial
| |
EVENTSNEW The Tumor Cell: Plasticity, Progression and Therapy Visit our events page to see a complete list of events in the community.
| |
JOB OPPORTUNITIESNEW Postdoctoral Associate – Biology of the Pancreas and Diabetes (University of Minnesota) Assistant/Associate/Full Professor – Diabetes & Neuroscience (Indiana University School of Medicine) Postdoctoral Position – Beta Cell Research (Helmholtz Zentrum Munchen) Lecturer/ Professor/ Clinical Academic – Diabetes (University of Exeter) Postdoctoral Research Fellow – Drivers of Pancreatic Cancer Metastasis (The Moffitt Cancer Center) Postdoctoral Associate – Type 1 Diabetes Research (University of Florida) Postdoctoral Positions – Immunology of Diabetes (Cochin Institute) Doctoral Thesis Position – Diabetes Research (Universite Libre de Bruxelles) Postdoctoral Fellow – Epigenetic Regulation of Pancreatic Beta-Cell Mass (City of Hope) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
| |
Have we missed an important article or publication in Pancreatic Cell News? Click here to submit! Comments or suggestions? Submit your feedback here. | |
|