Pancreatic Cell News 9.37 September 18, 2018 | |
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TOP STORYDiscovery and Characterization of Dual Inhibitors of MDM2 and NFAT1 for Pancreatic Cancer Therapy MA242 decreased cell proliferation and induced apoptosis in pancreatic cancer cell lines regardless of p53 status. MA242 alone or in combination with gemcitabine inhibited pancreatic tumor growth and metastasis without any host toxicity. [Cancer Res] Abstract | |
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PUBLICATIONS(Ranked by impact factor of the journal)DIABETES & PANCREATITISLocal Integrin Activation in Pancreatic β Cells Targets Insulin Secretion to the Vasculature In cultured β cells, 3D mapping showed enriched insulin granule fusion where the cells contacted extracellular matrix-coated coverslips, which depends on β1 integrin receptor activation. Culture on micro-contact printed stripes of E-cadherin and fibronectin showed that β cell contact at the fibronectin stripe selectively activated focal adhesions and enriched exocytic machinery and insulin granule fusion. [Cell Rep] Full Article | Graphical Abstract Hrb recruited VAMP7 and Atg9a from the plasma membrane to recycling endosomes. Knockdown of Hrb, Syntaxin16, and SNAP-47 resulted in defective autophagosome formation, accumulation of dysfunctional mitochondria and impairment of glucose-stimulated insulin secretion. [Endocrinology] Abstract Apoptotic Beta-Cells Induce Macrophage Reprogramming under Diabetic Conditions Investigators showed under diabetic conditions, phagocytosis of apoptotic β-cells caused lysosomal permeabilization and generated reactive oxygen species that led to inflammasome activation and cytokine secretion in macrophages. [J Biol Chem] Abstract | Full Article Scientists report that FGFR5 and FGFR1 expression improved beta-cell survival. They revealed that FGFR5 formed a mixture of ligand-independent homodimers and homotrimers at the plasma membrane. [J Biol Chem] Abstract | Full Article PANCREATIC CANCERPancreatic ductal adenocarcinoma (PDAC) cells were identified as a rich source of ceramide-1-phosphate (C1P). PDAC cells expressed the C1P converting enzyme ceramide kinase, secreted C1P-containing extracellular vesicles that mediate pancreatic cancer stem cell (PCSC) migration, and when co-injected with PCSCs reduced animal survival in a PDAC peritoneal dissemination model. [Biochem Pharmacol] Abstract | Graphical Abstract Researchers demonstrated that HIF-1α-mediated carbonic anhydrase IX (CA9) induction differed between patient-derived pancreatic ductal adenocarcinoma cells and that redox effector factor-1 (APE1/Ref-1) redox inhibition attenuated this induction by decreasing hypoxia-induced HIF-1 DNA binding. [Sci Rep] Full Article Cucurbitacin B (CuB) arrested pancreatic cancer cells in the G2/M cell cycle phase by suppressing the expression of actin filament-associated protein 1-antisense RNA 1 (AFAP1-AS1). The authors showed that the epidermal growth factor receptor and AFAP1-AS1 directly competed for miR-146b-5p binding. CuB-induced high miR-146b-5p expression and inhibited the expression of AFAP1-AS1. [J Cell Physiol] Abstract The porphyrins exhibited significant cytotoxicity and blocked metastasis by inhibiting the epithelial to messenchymal transition. The expression of KRAS gene in porphyrin-treated PANC-1, MiaPaCa2 and tumor-derived EAC cells were drastically reduced at both protein and RNA levels. [Eur J Pharm Sci] Abstract | Graphical Abstract Omega-3 Fatty Acids Prevent Early Pancreatic Carcinogenesis via Repression of the AKT Pathway Investigators discovered that, consistent with previous reports, the ω3-enriched diet led to reduced lesion penetrance via repression of proliferation associated with reduced phosphorylated AKT, whereas the ω6-enriched diet accelerated tumor formation. [Nutrients] Full Article Subscribe to one of our other 19 science newsletters such as Hepatic Cell News & Intestinal Cell News. | |
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REVIEWSImmune Checkpoint Molecules, Personalized Immunotherapy, and Autoimmune Diabetes The authors examine current knowledge of immune checkpoint molecules in type 1 diabetes (T1D). One specific immune checkpoint mechanism, namely tryptophan metabolism, may meet the need for a valid drug target and robust biomarker in the quest for effective and personalized immunotherapy in T1D. [Trends Mol Med] Abstract Visit our reviews page to see a complete list of reviews in the pancreatic cell research field. | |
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INDUSTRY NEWSNew Lilly Diabetes Center of Excellence Established at the Indiana Bioscience Research Institute Eli Lilly and Company and the Indiana Bioscience Research Institute, in collaboration with Indiana University School of Medicine, have created the Lilly Diabetes Center of Excellence, which aims to establish a nexus of strategically aligned basic diabetes research operations in Indianapolis. [Eli Lilly and Company] Press Release CRISPR Therapeutics and ViaCyte, Inc. announced a collaboration focused on the discovery, development, and commercialization of gene-edited allogeneic stem cell therapies for the treatment of diabetes. [ViaCyte, Inc.] Press Release Oramed Receives FDA Clearance for IND Application for Its Oral GLP-1 Analog Capsule Oramed Pharmaceuticals Inc. announced that the U.S. FDA has cleared its Investigational New Drug (IND) application for human trials of its oral GLP-1 analog capsule ORMD-0901. [Oramed] Press Release PharmaCyte Biotech Successfully Completes Final Pre-Production Run of Pancreatic Cancer Product PharmaCyte Biotech, Inc. announced that its partner, Austrianova, has successfully performed an additional pre-production “engineering run” using the Cell-in-a-Box® encapsulated cells that will be used, in combination with low doses of the cancer prodrug ifosfamide, for the treatment of locally advanced, non-metastatic, inoperable pancreatic cancer. [PharmaCyte Biotech Inc.] Press Release Novo Nordisk Announces Plans to Transform Its Approach to Research & Development Novo Nordisk announced plans to restructure its Research & Development organisation to accelerate the expansion and diversification of its pipeline across serious chronic diseases. [Novo Nordisk A/S] Press Release | |
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POLICY NEWSThe governing council of AAAS (publisher of Science) in Washington, D.C., unanimously adopted a policy on sexual harassment and other misconduct by scientists who have been elected as AAAS fellows. Starting on 15 October, fellows who have been proved to have violated professional ethics—which are defined as including sexual harassment—may be stripped of the prestigious honor. [ScienceInsider] Editorial NIH Set to Strengthen Its Sexual-Harassment Policies The US National Institutes of Health (NIH) is remaking how it handles allegations of harassment by its employees. The agency will soon introduce a centralized system for reporting harassment by NIH scientists, director Francis Collins said. [Nature News] Editorial Evidence-Based Medicine Group in Turmoil after Expulsion of Co-Founder A bitter dispute with one of its co-founders has plunged Cochrane, an international network of scientists promoting evidence-based medicine, into a crisis on the eve of an international gathering that marks its 25th anniversary. A narrow majority of the organization’s Governing Board apparently decided to end the Cochrane membership of Peter Gøtzsche, director of the Nordic Cochrane Centre in Copenhagen and a member of the board himself, for causing “disrepute” to the organization. Four other board members then resigned in protest. [ScienceInsider] Editorial
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EVENTSNEW AACR: Targeting RAS-Driven Cancers Visit our events page to see a complete list of events in the community.
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JOB OPPORTUNITIESNEW Research Technologist – Pancreatic (STEMCELL Technologies Inc.) NEW Postdoctoral Position – Metabolic Inflammation in Diabetes (Inserm) Assistant Professor – Biomedical Sciences (New York Institute of Technology) Scientists – Diabetes Research (Qatar Biomedical Research Institute) Caspar Wistar Fellows – Cancer Biology (The Wistar Institute) Postdoctoral Researcher – Diabetes Research (UC San Diego School of Medicine) Postdoctoral Associate – Biology of the Pancreas and Diabetes (University of Minnesota) Assistant/Associate/Full Professor – Diabetes & Neuroscience (Indiana University School of Medicine) Postdoctoral Positions – Immunology of Diabetes (Cochin Institute) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
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