 | | Vol. 12.29 – 6 August, 2021 |
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| In both PC3pip and LNCAP prostate cancer cells, crizotinib and marizomib nanomaterials demonstrated noticeable cytotoxic effects in a dose-responsive method.
[Journal of Biomaterials Science] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| The authors performed a kinome-scale CRISPR/Cas9 screen and identified cyclin-dependent kinase 12 as being conservatively required for prostate cancer cell survival.
[Molecular Cancer Therapeutics] |
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| Upon employing CCK-8 cell viability assays and colony formation assays, researchers found that indomethacin derivatives had high efficacy against castration-resistant prostate cancer tumor growth in vitro.
[Acta Pharmacologica Sinica] |
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| Synthesized compounds were evaluated for their in vitro anticancer activity against various human cancer cell lines, including breast and prostate.
[Bioorganic Chemistry] |
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| Scientists demonstrated that depletion of endogenous JAK1 enhanced docetaxel-induced apoptosis in prostate cancer cells.
[Journal of Cellular and Molecular Medicine] |
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| Investigators used flow cytometric analysis, cell viability assay, caspase activity analysis, wound healing assay, confocal microscopy study, and immunofluorescence to investigate the biological effect of high-frequency nanosecond pulses electric fields on prostate cancer cells.
[Scientific Reports] |
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| Since inorganic arsenic targets prostatic stem cells, researchers hypothesized that arsenic-transformed stem cells showed an impaired TLR3-associated anti-tumor pathway and, therefore, were unresponsive to polyinosinic:polycytidylic acid activation.
[Molecular Pharmacology] |
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| Researchers investigated the effect of Teucrium persicum extract on expression, cellular localization, and transcriptional activity of β-Catenin protein in PC-3 cells.
[Nutrition and Cancer] |
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| Scientists reported a Phase I–cleared orally bioavailable MTKI, ESK981, with a novel autophagy inhibitory property that decreased tumor growth in diverse preclinical models of castration-resistant prostate cancer.
[Nature Cancer] |
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| The authors review how canonical functions of Enhancer of Zeste Homolog 2 (EZH2) as a histone methyltransferase activity are regulated and describe the various mechanisms of Polycomb Repressive Complex 2 recruitment to the chromatin.
[Oncogene] |
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| Ambrx announced the first patient has been dosed in a Phase I, multicenter, open-label, dose-escalation, and dose expansion study to evaluate the safety, pharmacokinetics, and anti-tumor activity of ARX517 in subjects with prostate specific membrane antigen (PSMA) expressing tumors found in prostate, pancreatic, lung and ovarian cancers.
[Ambrx] |
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| September 22 – 25, 2021
Virtual |
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| | The University of British Columbia – Vancouver, British Columbia, Canada |
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| | Dalhousie University – Halifax, Nova Scotia, Canada |
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| | University of Kentucky – Lexington, Kentucky, United States |
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| | Augusta University – Augusta, Georgia, United States |
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| | Mayo Clinic Health System – Rochester, Minnesota, United States |
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