Prostate Cell News Volume 1.02 | Jan 22 2010

Wnt5a Signaling is Involved in the Aggressiveness of Prostate Cancer and Expression of Metalloproteinase
Results suggest that Wnt5a promotes the aggressiveness of prostate cancer and that its expression is involved in relapse after prostatectomy. [Oncogene]

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Prostate Cancer Screening Trial Raises Concerns about ‘False Positive’ Results
A large European trial has cast doubt over the viability of prostate cancer screening, concluding that one in eight men receive a positive test result when they do not have the disease. [University of Tampere, Tampere]

Magnetic Resonance Imaging Can Help Find Evasive Prostate Tumors
Magnetic resonance imaging can aid in identifying prostate tumors undetectable by digital rectal examination and in biopsy specimens. [Renal & Urology News]

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LABORATORY RESEARCH

Heat Shock Protein 27 Confers Resistance to Androgen Ablation and Chemotherapy in Prostate Cancer Cells through eIF4E
Using two-hybrid experiment, researchers found that Hsp27 was having a major role in the protein translational initiation process. [Oncogene]

Differential Regulation of MAP Kinase Activation by a Novel Splice Variant of Human MAP Kinase Phosphatase-2
These findings reveal the occurrence of a novel splice variant of MAP kinase phosphatase-2 which is unable to bind ERK and may be significant in the dysregulation of MAP kinase activity in certain disease states, particularly in breast and prostate cancers. [Cell Signal]

Role of IAPs in Prostate Cancer Progression: Immunohistochemical Study in Normal and Pathological (Benign Hyperplastic, Prostatic Intraepithelial Neoplasia and Cancer) Human Prostate
This study investigated IAPs in normal human prostate, benign prostatic hyperplasia, prostatic intraepithelial neoplasia and prostatic carcinoma, and their involvement in apoptosis/proliferation via NF-(kappa)B stimulation. [BMC Cancer]

Clusterin Facilitates COMMD1 and I-(kappa)B Degradation to Enhance NF-(kappa)B Activity in Prostate Cancer Cells
Elevated levels of secretory clusterin promote prostate cancer cell survival by facilitating degradation of COMMD1 and I-(kappa)B, thereby activating the canonical NF-(kappa)B pathway. [Mol Cancer Res]

CLINICAL RESEARCH

Prostatitis, Sexually Transmitted Diseases, and Prostate Cancer: The California Men’s Health Study
Researchers investigated the association between prostatitis, sexually-transmitted-diseases, and prostate cancer among African American, Asian American, Latino, and White participants of the California Men’s Health Study. [PLoS ONE]

False-Positive Screening Results in the Finnish Prostate Cancer Screening Trial
There is evidence that prostate cancer (PC) screening with prostate-specific antigen serum test decreases PC mortality, but screening has adverse effects, such as a high false-positive (FP) rate. Researchers investigated the proportion of FP rate in a population-based randomized screening trial in Finland. [Br J Cancer]

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Duncan Cancer Center Members Receive $11.5 Million in Inaugural State Cancer Prevention Grants
Researchers from the Dan L. Duncan Cancer Center at Baylor College of Medicine received 12 individual grants totaling $11.5 million in the first round of projects awarded through the Cancer Prevention and Research Institute of Texas. [Baylor College of Medicine Press Release]

PSMA & PSA Targeted Therapies for Prostate Cancer Analysed in New Research Report
The report "Competitor Analysis: PSMA & PSA Targeted Therapy" provides a competitor evaluation in the field of molecules targeting prostate specific membrane antigen or prostate specific antigen as of January 2010. [PRLog.Org Press Release]

Advisory Committees; Tentative Schedule of Meetings for 2010 [Food and Drug Administration, United States]

Proposed FDA Rulemaking on Informed Consent Requirements (NOT-OD-10-046) [National Institutes of Health, United States]

PHS 2010-02 Omnibus Solicitation of the NIH for Small Business Technology Transfer Grant Applications (PA-10-051) [National Institutes of Health, United States]

IACUC 101 and 201 PLUS Workshops: February 24-25, 2010 in Lafayette, LA (NOT-OD-10-044) [National Institutes of Health, United States]

7th Meeting of the EAU Section of Oncological Urology
January 15-17, 2010
Vienna, Austria

Stem Cells and Regenerative Medicine World Congress
January 20-21, 2010
San Francisco, United States

Phacilitate Cell and Gene Therapy Forum 2010
January 25-27, 2010
Washington DC, United States

CHI’s Molecular Medicine Tri-Conference 2010
February 3-5, 2010
San Francisco, United States

AACR/JCA Joint Conference: Cancer Genomics, Epigenomics, and the Development of Novel Therapeutics
February 5-9, 2010
Waikoloa, United States

SMi’s Second Annual Stem Cells 2010
February 15-16, 2010
London, United Kingdom

Keystone Symposia: Stem Cell Differentiation and Dedifferentiation (B4)
February 15-20, 2010
Keystone, United States

5th Annual Stem Cell Summit
February 16, 2010
New York, United States

Third International Symposium on Focal Therapy and Imaging of Prostate and Kidney Cancer
February 24-27, 2010
Washington, DC, United States

2010 Genitourinary Cancers Symposium: Progress in Multidisciplinary Management
March 5-7, 2010
San Francisco, United States

American Association for Cancer Research Annual Meeting
April 17-21, 2010
Washington, DC, United States

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