Prostate Cell News Volume 1.06 | Feb 19 2010

TOP STORY

Low Levels of Phosphorylated Epidermal Growth Factor Receptor in Nonmalignant and Malignant Prostate Tissue Predict Favorable Outcome in Prostate Cancer Patients
Low phosphorylated epidermal growth factor receptor immunoreactivity is associated with the favorable prognosis in prostate cancer patients and may provide information about which patients with Gleason score 6 and 7 tumors that will survive their disease even without treatment. [Clin Cancer Res]

CURRENT PUBLICATIONS

LABORATORY RESEARCH

Post-Transcriptional Regulation of Androgen Receptor mRNA by an ErbB3 Binding Protein 1 in Prostate Cancer
Here, researchers show that EBP1 promoted androgen receptor (AR) mRNA decay through physical interaction with a conserved UC-rich motif within the 3′-UTR of AR. [Nucleic Acids Res]

A Novel Role for PIAS Proteins in Modulating the Activity of Zimp7, a Novel PIAS-Like Protein, on the Androgen Receptor-Mediated Transcription
The results demonstrate a novel interaction between PIAS and PIAS-like proteins and elucidate a novel regulatory mechanism for PIAS proteins on androgen receptor mediated transcription. [J Biol Chem]

Eleven-Nineteen Lysine-Rich Leukemia is an HIF-1(alpha) Partner that Regulates and Responds to Hypoxia Response in PC3 Cells
Findings suggest that eleven-nineteen lysine-rich leukemia and HIF-1alpha are binding partners and can modulate the functions of each other in hypoxia. [Prostate]

Snail Transcription Factor Regulates Neuroendocrine Differentiation in LNCaP Prostate Cancer Cells
Overall, data provide evidence that Snail transcription factor may promote tumor aggressiveness in the LNCaP cells through multiple processes; induction of epithelial-mesenchymal transition may be required to promote migration, while neuroendocrine differentiation may promote tumor proliferation by a paracrine mechanism. [Prostate] 

Association of Hepsin Gene Variants with Prostate Cancer Risk and Prognosis
There was no evidence of altered risks of tumor recurrence/progression or prostate cancer death associated with variants in the hepsin gene. [Prostate] 

Differential Expression of the Alpha2 Chain of the Interleukin-13 Receptor in Metastatic Human Prostate Cancer ARCaP(M) Cells
Differential expression of the alpha2 chain of the interleukin-13 receptor may account for the high tumorigenic and metastatic potential of ARCaP(M) cells. [Prostate] 

Effect of Intermittent Fasting with or without Caloric Restriction on Prostate Cancer Growth and Survival in SCID Mice
This exploratory study found non-significant trends toward improved survival with some intermittent fasting regimens, in the absence of weight loss. [Prostate]

Differential Regulation of Steroid Nuclear Receptor Coregulator Expression Between Normal and Neoplastic Prostate Epithelial Cells
Data indicate differences in the regulation of coregulator expression between neoplastic and normal prostate cells. These findings emphasize the important potential of targeting the mechanisms regulating coregulator expression for therapeutic intervention in prostate cancer. [Prostate]
 
Inhibition of DHCR24/Seladin-1 Impairs Cellular Homeostasis in Prostate Cancer
Seladin-1 involvement in proliferation and secretion suggests that its downregulation may be a major mechanism causing prostate cancer evolution. Seladin-1 may thus potentially decrease cell growth and steroid dependency in low-grade prostate cancer. [Prostate]

CLINICAL RESEARCH

Phase II Multicenter Study of Abiraterone Acetate Plus Prednisone Therapy in Patients With Docetaxel-Treated Castration-Resistant Prostate Cancer
This trial evaluated the efficacy and safety of abiraterone acetate (AA) in combination with prednisone to reduce the symptoms of secondary hyperaldosteronism that can occur with AA monotherapy. [J Clin Oncol] 

Predictive Factors for Positive Surgical Margins and Their Locations After Robot-Assisted Laparoscopic Radical Prostatectomy
Researchers sought to identify predictive factors for positive surgical margins and their locations after robot-assisted laparoscopic radical prostatectomy. [Eur Urol]

Phase II Trial of Weekly Intravenous 1,25 Dihydroxy Cholecalciferol (Calcitriol) in Combination with Dexamethasone for Castration-Resistant Prostate Cancer
High-dose, iv calcitriol at a dose of 74 mug weekly in combination with dexamethasone was well tolerated but failed to produce a clinical or prostate-specific antigen response in men with castration-resistant prostate cancer. [Cancer] 

Health Disparities in Staging of SEER-Medicare Prostate Cancer Patients in the United States
Multivariable logistic regression models examined race and age disparities with respect to the odds of being staged among prostate cancer patients using surveillance, epidemiology, and end results-medicare data. [Urology]

Androgens, Growth Factors, and Risk of Prostate Cancer: The Multiethnic Cohort
Researchers conducted a nested case-control study of biomarkers of prostate cancer risk within the Multiethnic Cohort. [Prostate]

Johnson & Johnson’s Drug Helps in Last-Ditch Prostate Cancer Fight
Johnson & Johnson’s experimental drug abiraterone can help men with advanced prostate cancer who have run out of standard treatments options, according to results of a mid-stage clinical trial. [Reuters]

Victoria Prostate Groups Team Up to Boost Efficiency
To cut costs and boost performance, two local prostate cancer groups are joining forces.  The Prostate Centre and Vancouver Island Prostate Cancer Research Foundation have united under the Prostate Centre umbrella with psychologist Jim Ricks as chairman. [Victoria Times Colonist]

Cancer Test Firm DiagnoCure Cutting About 10 Jobs to Preserve Cash
DiagnoCure Inc. is cutting about 10 jobs as the developer of cancer-screening tests moves to preserve cash while it brings its latest tests for colorectal and prostate cancer to market. [The Canadian Press]

Jim Huber to Serve as National Spokesman for ‘Know Your Score: Fight Prostate Campaign’
Award-winning journalist and television personality Jim Huber will serve as the 2010 national spokesman of the “Know Your Score: Fight Prostate Cancer” Celebrity Golf Tournament and Gala scheduled August 28, 2010 in Myrtle Beach, S.C. [PR Newswire]

Portland Development Commission Spends $800,000 for Bioscience ‘Wet Labs’
Oregon’s biotech community will soon have access to four wet labs, where early stage companies can test and analyze chemicals and drugs. [Portland Business Journal]

Food and Drug Administration Budget Draws Cries of ‘Not Enough’
A coalition of interests will push for more money, saying chronic underfunding has led to failures at the agency and that society, not just companies, are affected. [Food and Drug Administration, United States]

Waivers for Conflicts of Interest for the February 22, 2010 Vaccines and Related Biological Products Advisory Committee Meeting [Center for Biologics Evaluation and Research, United States]

Delays in Grant Application Submission due to Widespread Winter Storm (NOT-OD-10-061) [National Institutes of Health, United States]

Recovery Act Limited Competition: Program to Enhance National Institutes of Health-Supported Global Health Research Involving Human Subjects (S07) (RFA-OD-10-006) [National Institutes of Health, United States]

Institutional Clinical and Translational Science Award (U54) (RFA-RM-10-001) [National Institutes of Health, United States]

IACUC 101 Workshop and PRIM&R 2010 IACUC Conference: March 21-23, 2010 in Baltimore, MD (NOT-OD-10-059) [National Institutes of Health, United States]

Notice of Intent to Establish a New National Institutes of Health Common Fund Program: Library of Integrated Network-Based Cellular Signatures (LINCS) (NOT-RM-10-002) [National Institutes of Health, United States]

Investigator Initiated Multi-Site Clinical Trials (Collaborative R01) (PAR-10-096) [National Institutes of Health, United States]

Expressions of Interest for Membership of the Therapeutic Goods Committee [Therapeutic Goods Administration, Australia]

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