TOP STORY
New Attack on Cancer Forces Cells to Grow Old and Die
A study in mice showed that blocking a cancer-causing gene called Skp2 forced cancer cells to go through an aging process known as senescence, the same process involved in ridding the body of cells damaged by sunlight. [Press release from Reuters discussing online prepublication in Nature]
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SCIENCE NEWS
Early Baldness and Lower Risk of Prostate Cancer Link ‘Not Conclusive’
Men who start losing their hair at an early age may be less likely to develop prostate cancer in the future, new research suggests. But Cancer Research UK said that the results contradict those of previous studies and that further research is needed to provide more reliable evidence. [Press release from Cancer Research UK discussing online prepublication in the journal Cancer Epidemiology]
Freezing Tumors Shows Promise Against Prostate, Breast Cancer
In two separate studies to be presented at the Society of Interventional Radiology’s annual meeting in Tampa, Fla., research teams reported success using cryotherapy to freeze and destroy malignant prostate tumors. [BusinessWeek Press Release]
Blame It On the B Cells
Hormones used to treat prostate cancers could trigger a chain of events that leads to even more dangerous cancers down the road, a study in mice suggests. [Nature News Press Release]
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CURRENT PUBLICATIONS
LABORATORY RESEARCH
Skp2 Targeting Suppresses Tumorigenesis by Arf-p53-Independent Cellular Senescence
Here researchers show that although Skp2 inactivation on its own does not induce cellular senescence, aberrant proto-oncogenic signals as well as inactivation of tumour suppressor genes do trigger a potent, tumour-suppressive senescence response in mice and cells devoid of Skp2. [Nature]
Protein Kinase C(Epsilon) Mediates Stat3Ser727 Phosphorylation, Stat3-Regulated Gene Expression, and Cell Invasion in Various Human Cancer Cell Lines Through Integration with MAPK Cascade (RAF-1, MEK1/2, and ERK1/2)
The results indicate that PKC(Epsilon)-mediated Stat3Ser727 phosphorylation is essential for constitutive activation of Stat3 and cell invasion in various human cancers. [Oncogene]
A NADPH Oxidase-Dependent Redox Signaling Pathway Mediates the Selective Radiosensitization Effect of Parthenolide in Prostate Cancer Cells
Researchers hypothesize that introducing additional reactive oxygen species (ROS) insults or suppressing antioxidant capacity may selectively enhance cancer cell killing by oxidative stress-generating agents through stress overload or stress sensitization, whereas normal cells may be able to maintain redox homeostasis under exogenous ROS by adaptive response. [Cancer Res]
Toll-Like Receptor 3-Mediated Suppression of TRAMP Prostate Cancer Shows the Critical Role of Type I Interferons in Tumor Immune Surveillance
In this study, researchers implicate toll-like receptor 3 (TLR3) in mediating immune surveillance with increased growth of implanted transgenic adenocarcinoma of the mouse prostate (TRAMP) tumors in TLR3-/- compared with TLR3+/+ mice. [Cancer Res]
Effects of Transplantation of Adipose Tissue-Derived Stem Cells on Prostate Tumor
Obesity is a risk factor for prostate cancer development, but the underlying mechanism is unknown. The present study tested the hypothesis that stromal cells of the adipose tissue might be recruited by cancer cells to help tumor growth. [Prostate]
Antagonists of Growth Hormone-Releasing Hormone Inhibit the Proliferation of Human Benign Prostatic Hyperplasia Cells
Growth hormone-releasing hormone (GHRH), besides stimulating the secretion of GH from the pituitary gland, acts as an autocrine/paracrine growth factor in many cancers. Antagonists of GHRH inhibit growth of experimental human tumors, but their effects on benign prostatic hyperplasia have not been studied. [Prostate]
Androgen Ablation Augments Human HLA2.1-Restricted T Cell Responses to PSA Self-Antigen in Transgenic Mice
Immunologic tolerance to human prostate tumor-associated antigens (TAA) poses a significant obstacle to effective, TAA-targeted immunotherapy. Researchers sought to investigate whether androgen deprivation would result in circumventing immune tolerance to prostate TAA by impacting CD8 cell responses. [Prostate]
Immunohistochemical Expression of Somatostatin Receptor Subtypes in Prostate Tissue from Cystoprostatectomies with Incidental Prostate Cancer
The purpose of this study was to examine immunohistochemically the expression of the five somatostatin receptors in cystoprostatectomies with incidental prostate cancer. [BJU Int]
CLINICAL RESEARCH
Value of Magnetic Resonance Spectroscopy Imaging and Dynamic Contrast-Enhanced Imaging for Detecting Prostate Cancer Foci in Men With Prior Negative Biopsy
This study aimed to prospectively analyze the role of magnetic resonance spectroscopy imaging and dynamic-contrast enhancement magnetic resonance in the detection of prostate tumor foci in patients with persistently elevated prostate-specific antigen levels and prior negative random trans-rectal ultrasound-guided biopsy. [Clin Cancer Res]
Prolonged Systemic Circulation of Chimeric Oncolytic Adenovirus Ad5/3-Cox2L-D24 in Patients with Metastatic and Refractory Solid Tumors
Ad5/3-Cox2L-D24 appears safe for treatment of cancer in humans and extended virus circulation results from a single treatment. Objective evidence of anti-tumor activity was seen in 11/18 (61%) of patients. [Gene Ther]
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POLICY NEWS
California Institute for Regenerative Medicine Allocates $50 Million for Stem Cell Therapy Development, a Boost for the State’s Growing Stem Cell Industry
In a move that will speed the path of bringing stem cell-based therapies to the people of California, the Governing Board of the California Institute for Regenerative Medicine, the state stem cell agency created by Proposition 71, approved a concept proposal for funding the development of new stem cell therapies. [California Institute for Regenerative Medicine, United States]
Spain Turns to Science for Stimulus
Spain’s ministers recently approved the text of a new research law that aims to reward scientific talent and encourage entrepreneurship. [Science and Innovation Ministry, Spain]
Technical Assistance for RFA-RM-10-006: Advancing Regulatory Science through Novel Research and Science-Based Technologies (U01) (NOT-RM-10-003) [National Institutes of Health, United States]
Modification: This Notice Modifies RFA-RM-09-019 (NOT-RM-10-004) [National Institutes of Health, United States]
Notice of a Change in the Next Receipt Date for the Center of Biomedical Research Excellence Program Announcement (PAR-09-079) (NOT-RR-10-005) [National Institutes of Health, United States]
Notice of Intent to Publish a Funding Opportunity for the Reissue of RFA-TW-08-002 the International Research Ethics Education and Curriculum Development Award (R25) (NOT-TW-10-326) [National Institutes of Health, United States]
Collaborative Research for Molecular and Genomic Studies of Behavior in Animal Models (R01) (PA-10-125) [National Institutes of Health, United States]
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EVENTS
American Association for Cancer Research (AACR) 101st Annual Meeting
April 17-21, 2010
Washington, DC, United States
American Urological Association (AUA) 2010 Annual Meeting
May 29-June 3, 2010
San Francisco, United States
International Society for Stem Cell Research (ISSCR) 8th Annual Meeting
June 16-19, 2010
San Francisco, United States
21st Meeting of the European Association for Cancer Research (EACR)
June 26-29, 2010
Oslo, Norway
United Kingdom National Stem Cell Network (UKNSCN) Third Annual Scientific Conference
July 12-14, 2010
Nottingham, United Kingdom
2010 World Cancer Congress
August 18-21, 2010
Beijing, China
The Joint Annual Meeting of the International Continence Society (ICS) and the International Urogynecological Association (IUGA)
August 23-27, 2010
Toronto, Canada
28th World Congress of Endourology and SWL
September 1-4, 2010
Chicago, United States
35th European Society for Medical Oncology (ESMO) Congress
October 8-10, 2010
Milan, Italy
Visit our events page to stay up to date with the latest events in the cell, gene and immunotherapy community.
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