SCIENCE NEWS Mayo Clinic Research Finds Surgery Outperforms Drug Therapy in Treatment of Benign Prostatic Hyperplasia A 17-year-long community study looking at symptoms of enlarged prostate in over 2,000 men age 40 to 79 years suggests that surgery for benign prostatic hyperplasia offers more relief from incontinence and obstruction symptoms than treatment from drug-based therapy, according to a new study. [Press release from the Mayo Clinic discussing research presented at the American Urological Association 2010 Annual Meeting] Nanoparticle PSA Test Predicts if Prostate Cancer Will Return New research shows that an ultrasensitive PSA test using nanoparticle-based technology may be able to definitively predict after surgery if the cancer is cured long term or if it will recur. [Press release from the Northwestern University Feinberg School of Medicine discussing research presented at the American Urological Association 2010 Annual Meeting] New Technique Detects Enzyme Implicated in Cancer, Atherosclerosis An enzyme implicated in osteoporosis, arthritis, atherosclerosis and cancer metastasis – cathepsin K – eluded reliable detection in laboratory experiments in the past. Now, a research team has developed an assay that reliably detects and quantifies mature cathepsin K using a technique called gelatin zymography. [Press release from the Georgia Institute of Technology discussing online prepublication in Analytical Biochemistry] Thymoquinone Induced Oxidative Stress Targets Highly Aggressive Prostate Cancers Researchers at the Tulane University School of Medicine, in New Orleans, LA, have demonstrated that thymoquinone, a major component of black seed oil (Nigella sativa), can suppress the growth of several aggressive prostate cancer cell lines, in vitro. [Press release from EurekAlert! discussing online prepublication in Experimental Biology and Medicine] Calcium Consumption May Cause Prostate Cancer in Chinese Among Chinese men, calcium consumption – even at relatively low levels and from non-dairy food sources such as soy, grains and green vegetables – may increase prostate cancer risk, according to results. [Press release from EurekAlert! discussing online prepublication in Cancer Research]
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CURRENT PUBLICATIONS (Ranked by Impact Factor of the Journal) LABORATORY RESEARCH Dicer Ablation Impairs Prostate Stem Cell Activity and Causes Prostate Atrophy To gain insight into the role of microRNAs in prostate tissue function and homeostasis, researchers conditionally disrupted Dicer activity in the mouse prostate using an ARR2PB-Cre system and demonstrated that Dicer activity is disrupted in both prostatic basal/stem cells and differentiated luminal cells. [Stem Cells] Predicting the Site of Origin of Tumors by a Gene Expression Signature Derived from Normal Tissues Whereas in past studies, cancer of unknown primary origin (CUP) classifiers were trained solely on data from tumor samples, researchers now use expression patterns from normal tissues for classifier training. [Oncogene] Transgenic Expression of 15-Lipoxygenase 2 (15-LOX2) in Mouse Prostate Leads to Hyperplasia and Cell Senescence To better understand the biological role of 15-lipoxygenase 2 (15-LOX2) in vivo, researchers generated 15-LOX2 transgenic mice using the ARR2PB promoter. [Oncogene] Copy Number Variation in Glutathione-S-Transferase T1 and M1 Predicts Incidence and 5-Year Survival from Prostate and Bladder Cancer, and Incidence of Corpus Uteri Cancer in the General Population Researchers determined the ability of glutathione-S-transferase copy number variation to predict the risk of cancer in the general population. [Pharmacogenomics J] Genomic Profiling of Tumor Initiating Prostatospheres Researchers intended to establish a comprehensive culture system to grow prostatospheres from both cancer cell lines and patient tumors. They then used gene expression microarrays to gain insight on the molecular pathways that sustain the prostatospheres tumor initiating cell phenotype. [BMC Genomics] Slug/SNAI2 Regulates Cell Proliferation and Invasiveness of Metastatic Prostate Cancer Cell Lines The data imply that SNAI2 exerts strong effects on the cytoskeleton and adhesion of those prostate cancer cells that express it and is necessary for their proliferation and invasiveness. [Tumour Biol] Studies on Molecular Mechanisms of Growth Inhibitory Effects of Thymoquinone Against Prostate Cancer Cells: Role of Reactive Oxygen Species Researchers investigated the mechanism of action of thymoquinone in androgen receptor (AR)-independent (C4-2B) and AR naïve (PC-3) prostate cancer cells, as models of aggressive prostate cancers. [Exp Biol Med] CLINICAL RESEARCH Phase I Study of Single-Agent Anti–Programmed Death-1 (MDX-1106) in Refractory Solid Tumors: Safety, Clinical Activity, Pharmacodynamics, and Immunologic Correlates This phase I study sought to determine the safety and tolerability of anti-PD-1 blockade in patients with treatment-refractory solid tumors and to preliminarily assess antitumor activity, pharmacodynamics, and immunologic correlates. [J Clin Oncol] Calcium Intake Increases Risk of Prostate Cancer among Singapore Chinese Researchers examined calcium intake and prostate cancer risk among 27,293 men in the Singapore Chinese Health Study that was established between 1993 and 1998. [Cancer Res]
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POLICY NEWS Treasury Releases New Guidance for Tax Credit in Affordable Care Act to Support Groundbreaking Biomedical Research The U.S. Department of the Treasury announced the guidelines for applying for the new Therapeutic Discovery Project Program created by the Affordable Care Act. [Department of the Treasury, United States] Third Time’s a Charm for COMPETES Bill By a vote of 262 to 150, legislators authorized $84 billion for research, education, and innovation programs over the next 5 years at the National Science Foundation, the Department of Energy, and two Department of Commerce agencies – NOAA and NIST under the America COMPETES Reauthorization Act (HR 5116). [House of Representatives, United States] Democrats: FDA Should Be Able to Recall Drugs House Democrats repeatedly called for federal regulators to be given the authority to recall drugs. Pending legislation would grant that power to the Food and Drug Administration (FDA) for food, but not for drugs. [House of Representatives, United States] Last Hurrah from National Academies Stem Cell Committee Even though the National Institutes of Health issued stem cell guidelines last year, there’s still a need for guidelines for research that remains off-limits for U.S. government-funded labs. [National Academies’ National Research Council and Institute of Medicine, United States] NIH Set to Tighten Financial Rules for Researchers After a wave of financial scandals over the past few years involving biomedical researchers, the U.S. National Institutes of Health (NIH) proposed far-reaching changes that would lead to tighter oversight of agency-funded extramural investigators and their institutions. [National Institutes of Health, United States] Request for Information (RFI) on the NIH Plan to Develop the Genetic Testing Registry (NOT-OD-10-101) [National Institutes of Health, United States] Administrative Supplements to Advance Special Translational Research Acceleration Projects on Immune Response Modifiers Currently Funded by the National Cancer Institute (NCI) (NOT-CA-10-025) [National Institutes of Health, United States]
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EVENTS International Society for Stem Cell Research (ISSCR) 8th Annual Meeting June 16-19, 2010 San Francisco, United States 21st Meeting of the European Association for Cancer Research (EACR) June 26-29, 2010 Oslo, Norway Translational Cancer Medicine 2010 – USA July 11-14, 2010 San Francisco, United States United Kingdom National Stem Cell Network (UKNSCN) Third Annual Scientific Conference July 12-14, 2010 Nottingham, United Kingdom 2nd International Conference on Cellular and Molecular Bioengineering (ICCMB2) August 2-4, 2010 Singapore City, Singapore CHI’s 5th Annual Immunotherapeutics and Vaccine Summit (ImVacS) August 17-19, 2010 Cambridge, United States 2010 World Cancer Congress August 18-21, 2010 Shenzhen, China Joint Annual Meeting of the International Continence Society (ICS) and International Urogynecological Association (IUGA) August 23-27, 2010 Toronto, Canada Select Biosciences 3rd Annual Stem Cells Europe Conference August 24-25, 2010 Edinburgh, Scotland Select Biosciences 2nd Annual World Biobanking Summit August 24-25, 2010 Edinburgh, Scotland Select Biosciences Inaugural Cellular Therapy Summit August 24-25, 2010 Edinburgh, Scotland 28th World Congress of Endourology and SWL September 1-4, 2010 Chicago, United States International Society for Cellular Therapy (ISCT) – Europe 2nd Regional Meeting September 11-14, 2010 Belgirate, Italy 35th European Society for Medical Oncology (ESMO) Congress October 8–12, 2010 Milan, Italy Visit our events page to stay up to date with the latest events in the cell, gene and immunotherapy community.
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