SCIENCE NEWS Protein Could Heal Erectile Dysfunction After Cancer Surgery After men have surgery to remove a cancerous prostate gland, up to 80 percent of them will lose the ability to have an erection because of damage to a critical nerve that runs along the prostate. New research shows the damaged nerve can be regenerated more quickly with the sonic hedgehog protein delivered via a nanofiber gel. [Press release from the Northwestern University Feinberg School of Medicine discussing research presented at the American Urological Association 2010 Annual Meeting] Genetic Markers Could Predict Prostate Cancer in Younger Men, Study Finds Prostate cancer has become more common in younger men, and it’s often more aggressive in these men. A new study has found that a series of genetic mutations could help detect this early onset prostate cancer. [Press release from the University of Michigan Comprehensive Cancer Center discussing research presented at the 46th Annual Meeting of the American Society of Clinical Oncology (ASCO)] Delay in Surgery Not Likely to Worsen Tumors in Men with Low-Risk Prostate Cancer Johns Hopkins experts have found that men enrolled in an active surveillance program for prostate cancer that eventually needed surgery to remove their prostates fared just as well as men who opted to remove the gland immediately, except if a follow-up biopsy during surveillance showed high-grade cancer. [Press release from EurekAlert! discussing research presented at the 46th Annual Meeting of the American Society of Clinical Oncology (ASCO)] Blood Vessel-Blocking Drug Slows Prostate Cancer Progression: Experts A blood vessel-blocking drug called tasquinimod slowed the rate of disease progression in a clinical trial of 200 prostate cancer patients, according to experts at Johns Hopkins, Roswell Park Cancer Institute and Duke University. [The Medical News]
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LABORATORY RESEARCH The Phosphoinositide 3-Kinase Regulatory Subunit p85(Alpha) Can Exert Tumor Suppressor Properties through Negative Regulation of Growth Factor Signaling Expression of Pik3r1, the gene encoding p85, is decreased in human prostate, lung, ovarian, bladder, and liver cancers, consistent with the possibility that p85 has tumor suppressor properties. Researchers tested this hypothesis by studying mice with a liver-specific deletion of the Pik3r1 gene. [Cancer Res] PSA Reduces Prostate Cancer Cell Motility by Stimulating TRPM8 Activity and Plasma Membrane Expression In this study, researchers identified the well-known prostate cancer marker, prostate-specific antigen (PSA), as a physiological transient receptor potential melastatin 8 (TRPM8) agonist. [Oncogene] Inhibition of Prostate Cancer Growth and Metastasis Using Small Interference RNA Specific for Minichromosome Complex Maintenance Component 7 In this study, researchers constructed a vector that constitutively expresses small interference RNA (siRNA) specific for MCM7. [Gene Ther] Micronutrients Attenuate Progression of Prostate Cancer by Elevating the Endogenous Inhibitor of Angiogenesis, Platelet Factor-4 Researchers present unprecedented data whereby these combined micronutrients effectively promotes tumor dormancy in early prostate cancer, following initiation mutations that may drive the angiogenesis-dependent response of the tumor, by inducing platelet factor-4 expression and concentrating it at the tumor endothelium through enhanced platelet binding. [BMC Cancer] CLINICAL RESEARCH Surgery Confounds Biology: The Predictive Value of Stage, Grade and Prostate-Specific Antigen for Recurrence After Radical Prostatectomy as a Function of Surgeon Experience Here researchers evaluate the association between several biological predictors and biochemical recurrence across varying surgical experience. [Int J Cancer] Periostin is Up-Regulated in High Grade and High Stage Prostate Cancer Here, researchers evaluated periostin expression in prostate cancer cells and peritumoural stroma immunohistochemically in two independent prostate cancer cohorts, including a training cohort (n=93) and a test cohort (n=325). [BMC Cancer]
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EVENTS International Society for Stem Cell Research (ISSCR) 8th Annual Meeting June 16-19, 2010 San Francisco, United States 21st Meeting of the European Association for Cancer Research (EACR) June 26-29, 2010 Oslo, Norway Translational Cancer Medicine 2010 – USA July 11-14, 2010 San Francisco, United States United Kingdom National Stem Cell Network (UKNSCN) Third Annual Scientific Conference July 12-14, 2010 Nottingham, United Kingdom 2nd International Conference on Cellular and Molecular Bioengineering (ICCMB2) August 2-4, 2010 Singapore City, Singapore CHI’s 5th Annual Immunotherapeutics and Vaccine Summit (ImVacS) August 17-19, 2010 Cambridge, United States 2010 World Cancer Congress August 18-21, 2010 Shenzhen, China Joint Annual Meeting of the International Continence Society (ICS) and International Urogynecological Association (IUGA) August 23-27, 2010 Toronto, Canada Select Biosciences 3rd Annual Stem Cells Europe Conference August 24-25, 2010 Edinburgh, Scotland Select Biosciences 2nd Annual World Biobanking Summit August 24-25, 2010 Edinburgh, Scotland Select Biosciences Inaugural Cellular Therapy Summit August 24-25, 2010 Edinburgh, Scotland 28th World Congress of Endourology and SWL September 1-4, 2010 Chicago, United States International Society for Cellular Therapy (ISCT) – Europe 2nd Regional Meeting September 11-14, 2010 Belgirate, Italy 35th European Society for Medical Oncology (ESMO) Congress October 8–12, 2010 Milan, Italy Visit our events page to stay up to date with the latest events in the cell, gene and immunotherapy community.
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