CURRENT PUBLICATIONS (Ranked by Impact Factor of the Journal) LABORATORY RESEARCH Estimation of Effect Size Distribution from Genome-Wide Association Studies and Implications for Future Discoveries Researchers report a set of tools to estimate the number of susceptibility loci and the distribution of their effect sizes for a trait on the basis of discoveries from existing genome-wide association studies. [Nat Genet] Integrative Genomic Profiling of Human Prostate Cancer Annotation of prostate cancer genomes provides a foundation for discoveries that can impact disease understanding and treatment. Concordant assessment of DNA copy number, mRNA expression, and focused exon resequencing in 218 prostate cancer tumors identified the nuclear receptor coactivator NCOA2 as an oncogene in ~11% of tumors. [Cancer Cell] Compensatory Upregulation of Tyrosine Kinase Etk/BMX in Response to Androgen Deprivation Promotes Castration-Resistant Growth of Prostate Cancer Cells Here, researchers report that Etk is upregulated in both human and mouse prostates in response to androgen ablation. [Cancer Res] Differential Roles of ERK and Akt Pathways in Regulation of EGFR-Mediated Signaling and Motility in Prostate Cancer Cells In this study, researchers use the human prostate cancer cell lines, DU145 and PC3, to investigate the effects of both the ERK and Akt pathways on epidermal growth factor (EGF)-mediated EGFR signaling, trafficking and cell motility. [Oncogene] The Wnt Inhibitory Factor 1 Restoration in Prostate Cancer Cells was Associated with Reduced Tumor Growth, Decreased Capacity of Cell Migration and Invasion and a Reversal of Epithelial to Mesenchymal Transition Researchers investigated the effect and underlying mechanism of a naturally-occurring Wnt inhibitor, WIF1, on the growth and cellular invasiveness of a bone metastatic prostate cancer cell line, PC3. [Mol Cancer] Robust Multi-Tissue Gene Panel for Cancer Detection Researchers have identified a set of genes whose relative mRNA expression levels in various solid tumors can be used to robustly distinguish cancer from matching normal tissue. [BMC Cancer] Chlordecone Exposure and Risk of Prostate Cancer Researchers analyzed the relationship between exposure to chlordecone and the risk of prostate cancer. [J Clin Oncol] Outcomes in Localized Prostate Cancer: National Prostate Cancer Register of Sweden Follow-Up Study A 10-year prostate cancer-specific mortality of 2.4% among patients with low-risk prostate cancer in the surveillance group indicates that surveillance may be a suitable treatment option for many patients with low-risk disease. [J Natl Cancer Inst] Maximum Tumor Diameter: A Simple Independent Predictor for Biochemical Recurrence after Radical Prostatectomy The significance of maximum tumor diameter in biochemical recurrence (BCR) prediction was evaluated using radical prostatectomy specimens of 364 patients with a BCR of 18% (n=66) during a mean follow-up of 37.4 months. [Prostate Cancer Prostatic Dis]
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POLICY NEWS Hospital Clínic de Barcelona Obtained the First Accreditation for Cell Therapy Research The certification, awarded for the first time in Catalonia, allows the Hospital Clínic de Barcelona to produce drugs in gene therapy, cell therapy and tissue engineering. [Spanish Medicines Agency, Spain] New Videos Reveal How NIH Identifies the Most Promising Research Applications The National Institutes of Health’s Center for Scientific Review released a new video to show new applicants and others how NIH assesses over 80,000 grant applications each year to help find those with the most merit. [National Institutes of Health, United States] NIH and Wellcome Trust Announce Partnership to Support Genomic, Population-Based Studies in Africa The National Institutes of Health (NIH) and the Wellcome Trust announced a partnership with African researchers to conduct genetic and environmental studies in Africa of common, non-communicable disorders, such as heart disease and cancer, as well as communicable diseases, such as malaria. [National Institutes of Health, United States] Publication of New Enforcement Strategy A new enforcement strategy has been published by the Inspection, Enforcement and Standards Division. [Medicines and Healthcare Products Regulatory Agency, United Kingdom] FDA/CDRH Public Meeting: Oversight of Laboratory Developed Tests (LDTs), Date July 19-20, 2010 [Food and Drug Administration, United States] Drugs Designated as Orphan Drugs [Therapeutic Goods Administration, Australia] Therapeutic Goods Committee (TGC) (Updated) [Therapeutic Goods Administration, Australia]
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EVENTS 21st Meeting of the European Association for Cancer Research (EACR) June 26-29, 2010 Oslo, Norway Translational Cancer Medicine 2010 – USA July 11-14, 2010 San Francisco, United States United Kingdom National Stem Cell Network (UKNSCN) Third Annual Scientific Conference July 12-14, 2010 Nottingham, United Kingdom 2nd International Conference on Cellular and Molecular Bioengineering (ICCMB2) August 2-4, 2010 Singapore City, Singapore CHI’s 5th Annual Immunotherapeutics and Vaccine Summit (ImVacS) August 17-19, 2010 Cambridge, United States 2010 World Cancer Congress August 18-21, 2010 Shenzhen, China Joint Annual Meeting of the International Continence Society (ICS) and International Urogynecological Association (IUGA) August 23-27, 2010 Toronto, Canada Select Biosciences 3rd Annual Stem Cells Europe Conference August 24-25, 2010 Edinburgh, Scotland Select Biosciences 2nd Annual World Biobanking Summit August 24-25, 2010 Edinburgh, Scotland Select Biosciences Inaugural Cellular Therapy Summit August 24-25, 2010 Edinburgh, Scotland 28th World Congress of Endourology and SWL September 1-4, 2010 Chicago, United States International Society for Cellular Therapy (ISCT) – Europe 2nd Regional Meeting September 11-14, 2010 Belgirate, Italy 35th European Society for Medical Oncology (ESMO) Congress October 8–12, 2010 Milan, Italy Visit our events page to stay up to date with the latest events in the cell, gene and immunotherapy community.
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