SCIENCE NEWS Statins Associated with Lower Cancer Recurrence Following Prostatectomy Men who use statins to lower their cholesterol are 30 percent less likely to see their prostate cancer come back after surgery compared to men who do not use the drugs, according to researchers. [Press release from Duke University Medical Center discussing online prepublication in Cancer] New Research Model of Human Prostate Cancer Shows Cancer Development Progress toward understanding the role of sex hormones in the growth of prostate cancer has been hindered by the lack of a suitable laboratory research model. Now researchers say they have developed the first model of hormone-induced human prostate cancer initiation and progression. [Press release from EurekAlert! discussing research presented at The Endocrine Society’s 92nd Annual Meeting in San Diego] PSA Test Does Cut Prostate Cancer Deaths, Study Finds Adding to the ongoing debate on the usefulness of the prostate-specific antigen blood test for prostate cancer, new research from Sweden finds the screen cuts lives lost to the disease by almost half. [Press release from HealthDay discussing online prepublication in The Lancet Oncology]
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CURRENT PUBLICATIONS (Ranked by Impact Factor of the Journal) LABORATORY RESEARCH Nanoparticle-Induced Vascular Blockade in Human Prostate Cancer Previous results show that CREKA-coated superparamagnetic iron oxide particles can cause additional clotting in tumor vessels, which creates more binding sites for the peptide. Researchers have used this self-amplifying homing system to develop theranostic nanoparticles that simultaneously serve as an imaging agent and inhibit tumor growth by obstructing tumor circulation through blood clotting. [Blood] Nrdp1-Mediated Regulation of ErbB3 Expression by the Androgen Receptor in Androgen-Dependent but not Castrate-Resistant Prostate Cancer Cells Here, researchers show that androgen withdrawal (AW) can promote castration-resistant prostate cancer development by increasing the levels of the receptor tyrosine kinase ErbB3 in androgen-dependent prostate cancer, resulting in AW-resistant cell cycle progression and increased androgen receptor transcriptional activity. [Cancer Res] STAMP1 Is Both a Proliferative and an Antiapoptotic Factor in Prostate Cancer Here, researchers find that ectopic expression of STAMP1 significantly increased proliferation of DU145 prostate cancer cells as well as COS-7 cells in vitro; conversely, small interfering RNA-mediated knockdown of STAMP1 expression in LNCaP cells inhibited cell growth and, at least partially, induced cell cycle arrest. [Cancer Res] Opposing Roles of Dnmt1 in Early and Late Stage Murine Prostate Cancer Here, researchers utilized Dnmt1 hypomorphic alleles to examine the role of Dnmt1 in normal prostate development, and prostate cancer in TRansgenic Adenocarcinoma of Mouse Prostate (TRAMP). [Mol Cell Biol] The Functional Significance of MicroRNA-145 in Prostate Cancer One of the genes significantly upregulated by microRNA-145 overexpression is the proapoptotic gene TNFSF10. Therefore, modulation of microRNA-145 may be an important therapeutic approach for the management of prostate cancer. [Br J Cancer] VMY-1-103, A Dansylated Analog of Purvalanol B, Induces Caspase-3-Dependent Apoptosis in LNCaP Prostate Cancer Cells The results demonstrate that VMY-1-103 was more effective in inducing apoptosis in prostate cancer cells than its parent compound, purvalanol B, and support the testing of VMY-1-103 as a potential small molecule inhibitor of prostate cancer in vivo. [Cancer Biol Ther] ERG Oncoprotein Expression in Prostate Cancer: Clonal Progression of ERG-Positive Tumor Cells and Potential for ERG-Based Stratification Through exhaustive evaluations of 132 whole-mount prostates for the ERG oncoprotein nuclear expression, researchers demonstrated 99.9% specificity for detecting prostate tumor cells using a highly specific anti-ERG monoclonal antibody. [Prostate Cancer Prostatic Dis] CLINICAL RESEARCH Baseline PSA as a Predictor of Prostate Cancer-Specific Mortality Over the Past Two Decades The Duke Prostate Center database was used to identify men who had their PSA level measured over the past 20 years. The Cox proportional hazards model was used to assess whether baseline PSA, race, and age at baseline PSA could predict death from prostate cancer and death from all causes after baseline PSA measurement. [Cancer] INDUSTRY NEWS OHSU Knight Cancer Institute Among First in Nation to Treat Prostate Cancer Patients With New Immunotherapy The Oregon Health & Science University Knight Cancer Institute will be among the first sites in the nation to treat advanced prostate cancer patients with the newest drug approved by the FDA to fight the disease. [OHSU Knight Cancer Institute Press Release] OncoGenex Pharmaceuticals Announces Initiation of a Phase III Trial in Men with Metastatic Prostate Cancer OncoGenex Pharmaceuticals, Inc. announced the initiation of a Phase III registration trial of custirsen sodium (OGX-011/TV-1011), its lead product candidate being developed for the treatment of castrate-resistant prostate cancer. [OncoGenex Pharmaceuticals, Inc. Press Release]
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