SCIENCE NEWS UNC Team Finds New Target for Treatment of Advanced Prostate Cancer A recent study provides evidence for a theory demonstrating that expression of one of a group of genes found only in humans and non-human primates can promote androgen receptor activity in concert with coregulators. [Press release from the UNC School of Medicine discussing online prepublication in Journal of Biological Chemistry] Baseline PSA Predicts Risk of Death from Prostate Cancer Men who have a baseline PSA value of 10 or higher the first time they are tested are up to 11 times more likely to die from prostate cancer than men with lower initial values, according to researchers. [Press release from the Duke University Health System discussing online prepublication in Cancer]
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CURRENT PUBLICATIONS (Ranked by Impact Factor of the Journal) LABORATORY RESEARCH Protein Tyrosine Kinase 6 Directly Phosphorylates AKT and Promotes AKT Activation in Response to Epidermal Growth Factor Here, researchers demonstrate that AKT is a direct substrate of PTK6, and that AKT tyrosine residues 315 and 326 are phosphorylated by PTK6. [Mol Cell Biol] Purinergic Receptor-Mediated Rapid Depletion of Nuclear pAkt Depends on PH Domain Leucine-Rich Repeat Phosphatase (PHLPP), Calcineurin, PP2A and PTEN Phosphatases Researchers have previously described a rapid and P2X7-dependent depletion of nuclear phosphorylated Akt (pAkt) and effects on downstream targets. Here, they studied mechanisms behind the pAkt depletion. [J Biol Chem] Fkbp52 Regulates Androgen Receptor Transactivation Activity and Male Urethra Morphogenesis Taken together, the data show FK506-binding protein-52 (Fkbp52) to be an important molecular regulator in the androgen-mediated pathway of urethra morphogenesis. [J Biol Chem] Baseline PSA as a Predictor of Prostate Cancer-Specific Mortality Over the Past 2 Decades A diagnosis of prostate cancer is not often predictive of death from prostate cancer because of competing causes of mortality. Identification of the risk of death from prostate cancer and death from all causes using information available at the time of baseline prostate-specific antigen (PSA) measurement appears to be particularly pertinent. [Cancer] Association of Core Binding Factor with the Malignant Phenotype of Prostate and Ovarian Cancer Cells To test whether Core Binding Factor (CBF) is required for the malignant phenotype of various epithelial cancers, researchers used lentiviral delivery of CBF-beta specific shRNA to significantly decrease CBF-beta expression in two prostate cancer cell lines (PPC1 and PC-3) and the SKOV-3 ovarian cancer cell line. [J Cell Physiol] p53 Downregulates the Gene Expression of Mitochondrial Aconitase in Human Prostate Carcinoma Cells Researchers investigated whether p53 regulates mitochondrial aconitase (mACON) expression and explore the potential mechanisms responsible for its effect on prostate cancer cells. [Prostate] Liposomal Imatinib-Mitoxantrone Combination: Formulation Development and Therapeutic Evaluation in an Animal Model of Prostate Cancer The loading parameters and drug retention properties of the liposomal imatinib-mitoxantrone formulation, combined with its in vivo antitumor activity, make this formulation an excellent strategy to improve the therapeutic index of mitoxantrone and a promising candidate for clinical development in prostate cancer therapy. [Prostate] Role of Monocyte-Lineage Cells in Prostate Cancer Cell Invasion and Tissue Factor Expression Tissue factor (TF) is a cell surface glycoprotein intricately related to blood coagulation and inflammation. This study was performed to investigate the role of monocyte-lineage cells in prostate cancer cell TF expression and cell invasion. [Prostate] CLINICAL RESEARCH Mortality Results From the Göteborg Randomised Population-Based Prostate-Cancer Screening Trial Prostate cancer is one of the leading causes of death from malignant disease among men in the developed world. One strategy to decrease the risk of death from this disease is screening with prostate-specific antigen (PSA); however, the extent of benefit and harm with such screening is under continuous debate. [Lancet Oncol] Radionuclide and Hybrid Imaging of Recurrent Prostate Cancer Here, researchers review the contribution of radionuclide imaging and hybrid imaging for assessment of recurrent prostate cancer (local vs regional vs distant disease). [Lancet Oncol] INDUSTRY NEWS Claros Diagnostics Receives CE Mark Approval for Point-of-Care PSA System Claros Diagnostics announced the CE Mark approval for its rapid quantitative point-of-care diagnostic platform, which can now be used for prostate specific antigen (PSA) testing throughout the European Union. [Claros Diagnostics Press Release]
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POLICY NEWS Research Budgets Face Austerity in 2012 The National Institutes of Health and other life sciences and biomedical research funding agencies will need to trim their budgets for 2012, which are to be planned over the summer, to satisfy a White House that is now stressing deficit reduction and belt-tightening after two years of stimulus funding-boosted research budgets. [The Office of Management and Budget, United States] The Reality of Human Stem Cell Research in Europe A new report from the European Science Foundation examines the key scientific questions for human stem cell research in the context of the rapidly emerging field of regenerative medicine. [European Science Foundation, European Union] Strong Medicine for French Research The medical-research adviser to France’s president aims to shift power and money to universities. [National Research Agency, France] Meeting of the National Advisory Council for Healthcare Research and Quality [Agency for Healthcare Research and Quality, United States] Maryland Stem Cell Research Commission – Public Meeting Notice [Maryland Stem Cell Research Commission, United States] Center for Scientific Review; Notice of Closed Meetings [National Institutes of Health, United States] Science Board Advisory Committee; Notice of Meeting (Docket No. FDA-2010-N-0001) [Food and Drug Administration, United States] Guidance for Industry: Adaptive Design Clinical Trials for Drugs and Biologics [Food and Drug Administration, United States] Medical Devices; Availability of Safety and Effectiveness Summaries for Premarket Approval Applications (Docket Nos. FDA-2010-M-0068, FDA-2010-M-0078, FDA-2010-M-0063, FDA-2010-M-0135, FDA-2010-M-0158) [Food and Drug Administration, United States]
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EVENTS Translational Cancer Medicine 2010 – USA July 11-14, 2010 San Francisco, United States United Kingdom National Stem Cell Network (UKNSCN) Third Annual Scientific Conference July 12-14, 2010 Nottingham, United Kingdom 2nd International Conference on Cellular and Molecular Bioengineering (ICCMB2) August 2-4, 2010 Singapore City, Singapore CHI’s 5th Annual Immunotherapeutics and Vaccine Summit (ImVacS) August 17-19, 2010 Cambridge, United States 2010 World Cancer Congress August 18-21, 2010 Shenzhen, China Joint Annual Meeting of the International Continence Society (ICS) and International Urogynecological Association (IUGA) August 23-27, 2010 Toronto, Canada Select Biosciences 3rd Annual Stem Cells Europe Conference August 24-25, 2010 Edinburgh, Scotland Select Biosciences 2nd Annual World Biobanking Summit August 24-25, 2010 Edinburgh, Scotland Select Biosciences Inaugural Cellular Therapy Summit August 24-25, 2010 Edinburgh, Scotland 28th World Congress of Endourology and SWL September 1-4, 2010 Chicago, United States International Society for Cellular Therapy (ISCT) – Europe 2nd Regional Meeting September 11-14, 2010 Belgirate, Italy 35th European Society for Medical Oncology (ESMO) Congress October 8–12, 2010 Milan, Italy Visit our events page to stay up to date with the latest events in the cell, gene and immunotherapy community.
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