SCIENCE NEWS BMD Testing Underused in ADT Recipients Bone mineral density (BMD) testing and bisphosphonate use are significantly underused in men receiving androgen deprivation therapy (ADT) for prostate cancer, a new study suggests. [Renal & Urology News on study presented at the Canadian Urological Association’s Annual Meeting]
Salvage Cryotherapy an Option for Radiation Treatment Failures New findings from a Canadian study support the use of salvage cryotherapy for prostate cancer patients who experience disease recurrence after radiation treatment. [Renal & Urology News on study presented at the Canadian Urological Association’s Annual Meeting]
|
CURRENT PUBLICATIONS (Ranked by Impact Factor of the Journal) LABORATORY RESEARCH Castration Resistance in Human Prostate Cancer is Conferred by a Frequently Occurring Androgen Receptor Splice Variant Here, investigators have identified a novel human androgen receptor splice variant in which exons 5, 6, and 7 are deleted and demonstrated that this variant can contribute to cancer progression in human prostate cancer xenograft models in mice following castration. [J Clin Invest] 3[Beta]-Hydroxysteroid Dehydrogenase Is a Possible Pharmacological Target in the Treatment of Castration-Resistant Prostate Cancer The findings demonstrate that dehydroepiandrosterone and [delta]5-androstenediolmust be metabolized by 3[beta]-hydroxysteroid dehydrogenase to activate androgen receptor in these models of castration-resistant prostate cancer. [Endocrinology] Proteomic Profiling of Potential Molecular Targets of Methyl-Selenium Compounds in the Transgenic Adenocarcinoma of Mouse Prostate (TRAMP) Model The present work applied iTRAQ proteomic approach to profile protein changes of the TRAMP prostate and characterized their modulation by methylselenic acid and Se-methylselenocysteine to identify their potential molecular targets. [Cancer Prev Res] Genome-Wide Analysis of Androgen Receptor Binding and Gene Regulation in Two CWR22-Derived Prostate Cancer Cell Lines In this study, researchers investigated androgen receptor (AR) binding and AR-dependent transcription in two related castrate-resistant cell lines derived from androgen-dependent CWR22 relapsed tumors: CWR22Rv1 and CWR-R1. [Endocr Relat Cancer] P53-Dependent Induction of Prostate Cancer Cell Senescence by the PIM1 Protein Kinase Based on the results, PIM1 will have its most profound effects on tumorigenesis in situations where the senescence response is inactivated. [Mol Canc Res] Cryptotanshinone Sensitizes DU145 Prostate Cancer Cells to Fas(APO1/CD95)-Mediated Apoptosis Through Bcl-2 and MAPK Regulation In the present study, researchers demonstrated that the apoptosis inhibitory protein, Bcl-2, was highly expressed in response to Fas in DU145 prostate cancer cells, thereby conferring resistance to apoptosis. [Cancer Lett] Knockdown of Akt isoforms by RNA Silencing Suppresses the Growth of Human Prostate Cancer Cells In Vitro and In Vivo Here, researchers investigated the expression and function of Akt isoforms in human prostatic carcinoma cells. [Biochem Biophys Res Commun] CLINICAL RESEARCH Diagnosis of Prostate Cancer by Detection of Minichromosome Maintenance 5 Protein in Urine Sediments In this study, researchers investigated minichromosome maintenance-5 as a urinary biomarker for prostate cancer detection. [Br J Cancer] Open-Label, Phase I Dose-Escalation Study of Sodium Selenate, a Novel Activator of PP2A, in Patients with Castration-Resistant Prostate Cancer Sodium selenate is well tolerated at a dose of 60mg per day with modest single-agent efficacy similar to other anti-angiogenic agents. [Br J Cancer] Prostate Specific Antigen Velocity Does Not Aid Prostate Cancer Detection in Men With Prior Negative Biopsy Researchers determined whether prostate specific antigen velocity could predict repeat biopsy results in men with persistently increased prostate specific antigen after initial negative biopsy. [J Urol]
|
POLICY NEWS USC to Lead Prostate Cancer Study Researchers received a $12 million National Cancer Institute grant to lead an international project aimed at identifying new biological pathways critical to the development and potential treatment of prostate cancer. [USC Norris Comprehensive Cancer Center ] “Game Over” for British Science? The Royal Society and the British Academy strongly warned the British government that looming cuts to science funding could be “irreversibly catastrophic for the future of U.K. science and economic growth” if they go too far. [The Royal Society and the British Academy, United Kingdom] House Panel Approves 3.2% Raise for NIH in 2011 A House of Representatives spending panel yesterday approved a $1 billion increase, to $32 billion, in the 2011 budget for the National Institutes of Health (NIH). [National Institutes of Health, United States] 2011 NIH Directors New Innovator Award Program (DP2) (RFA-RM-10-009) [National Institutes of Health, United States] Prospective Grant of Exclusive License: The Development of Human Therapeutics for the Treatment of Cancer [National Institutes of Health, United States] Pre-Application Meeting for Request for Applications (RFA-CA-10-016) for the Clinical Proteomic Technologies for Cancer Initiative (CPTC): Proteome Characterization Centers (NOT-CA-10-031) [National Institutes of Health, United States] Notice of Intent to Publish a Request for Applications for Tumor Microenvironment Network (TMEN) (NOT-CA-10-032) [National Institutes of Health, United States] NIMH Announces Availability of Funds for Competitive Revision Applications for a Repository Supporting Stem Cell Research Relevant to Mental Disorders (U24) (NOT-MH-10-024) [National Institute of Mental Health, United States] NASA SBIR/STTR 2010 Phase I Solicitation [Small Business Innovation Research, United States]
|
EVENTS (Listed by Date) The Tissue and Cell Engineering Society 2010 Meeting July 28-30, 2010 Manchester, United Kingdom 2nd International Conference on Cellular and Molecular Bioengineering (ICCMB2) August 2-4, 2010 Singapore City, Singapore 9th Mount Desert Island Stem Cell Symposium August 6-7, 2010 Salsbury Cove, United States NEW Australian-Canadian Prostate Cancer Research Alliance Symposium August 6-8, 2010 Gold Coast, Australia CHI’s 5th Annual Immunotherapeutics and Vaccine Summit (ImVacS) August 17-19, 2010 Cambridge, United States 2010 World Cancer Congress August 18-21, 2010 Shenzhen, China Joint Annual Meeting of the International Continence Society (ICS) and International Urogynecological Association (IUGA) August 23-27, 2010 Toronto, Canada Select Biosciences Inaugural Cellular Therapy Summit August 24-25, 2010 Edinburgh, Scotland Select Biosciences 2nd Annual World Biobanking Summit August 24-25, 2010 Edinburgh, Scotland Select Biosciences 3rd Annual Stem Cells Europe Conference August 24-25, 2010 Edinburgh, Scotland 28th World Congress of Endourology and SWL September 1-4, 2010 Chicago, United States NEW Prostate Cancer Research Institute Conference 2010 September 11-12, 2010 California, United States International Society for Cellular Therapy (ISCT) – Europe 2nd Regional Meeting September 11-14, 2010 Belgirate, Italy Tissue Engineering and Regenerative Medicine International Society (TERMIS) – Asia Pacific 2010 September 15-17, 2010 Sydney, Australia 35th European Society for Medical Oncology (ESMO) Congress October 8–12, 2010 Milan, Italy NEW Frontiers in Tumour Progression October 24-27, 2010 Madrid, Spain NEW Cancer Pharmacogenetics: Personalising Medicine November 22-24, 2010 Madrid, Spain Visit our events page to stay up to date with the latest events in the cell, gene and immunotherapy community.
JOB OPPORTUNITIES Recruit Top Talent Reach more than 11,000 potential candidates by posting your organization’s career opportunities with Prostate Cell News. Visit here to post your career opportunities.
Have we missed an important article or publication in Prostate Cell News? Click here to submit! Comments or Suggestions? Email info@connexoncreative.com with your feedback. |
|
|