SCIENCE NEWS Light at Night and Cancer A new study from has found an additional link between Light At Night and cancer. [University of Haifa Press Release] Novel Nanotechnology Collaboration Leads to Breakthrough in Cancer Research Researchers have teamed up to not only visualize a virus but to use the results to adapt the virus so that it can deliver medication instead of disease. [Press release from the University of California, Los Angeles discussing online prepublication in Science] Worms Point to a Link Between Cellular Glue and Cancer Growth Scientists have discovered that a protein that helps make cells sticks together also keeps them from dividing excessively, a hallmark of cancer progression. [Press release from the University of California, Santa Barbara discussing online prepublication in Proceedings of the National Academy of Sciences USA] New Model May Simplify High-Dose Radiosurgery Planning There is yet no straightforward way to determine the optimal dose level and treatment schedules for high-dose radiation therapies such as stereotactic radiation therapy, which is used to treat brain and lung cancer, or for high-dose brachytherapy for prostate and other cancers. Radiation oncologists may have solved the problem by developing a new mathematical model that encompasses all dose levels. [Press release from the Ohio State University Comprehensive Cancer Center discussing online prepublication in Science Translational Medicine]
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CURRENT PUBLICATIONS (Ranked by Impact Factor of the Journal) LABORATORY RESEARCH Atomic Structure of Human Adenovirus by Cryo-EM Reveals Interactions Among Protein Networks Here, researchers report the structure of the whole human adenovirus virion at 3.6 angstroms resolution by cryo-electron microscopy (cryo-EM), revealing in situ atomic models of three minor capsid proteins (IIIa, VIII, and IX), extensions of the (penton base and hexon) major capsid proteins, and interactions within three protein-protein networks. [Science] Repression of Wnt Signaling by a Fer-Type Nonreceptor Tyrosine Kinase Researchers found that the Caenorhabditis elegans ortholog of the Fer nonreceptor tyrosine kinase, FRK-1, limits Wnt signaling by preventing the adhesion complex-associated beta-catenin, HMP-2, from participating in Wnt-dependent specification of the endoderm during embryogenesis. [Proc Natl Acad Sci USA] Tubulin-Targeting Chemotherapy Impairs Androgen Receptor Activity in Prostate Cancer This study investigates the contribution of microtubules and the cytoskeleton to androgen-mediated signaling, and the consequences of their inhibition on androgen receptor activity in human prostate cancer. [Cancer Res] Thymus-Derived Glucocorticoids Mediate Androgen Effects on Thymocyte Homeostasis Researchers provide here an unrecognized mechanism how androgens contribute to thymic involution by stimulating local synthesis and release of glucocorticoids in the thymus. [FASEB J] PIM Kinase Inhibitors Downregulate STAT3Tyr705 Phosphorylation These results identify a novel role for PIM-3 kinase as a positive regulator of signal transducer and activator of transcription 3 (STAT3) signaling and suggest that PIM-3 inhibitors cause growth inhibition of cancer cells by downregulating the expression of pSTAT3Tyr705. [Mol Cancer Ther] Ultrasound Molecular Imaging of VEGFR2 in a Rat Prostate Tumor Model Using BR55 The purpose of this study is to evaluate BR55, a new VEGFR2-specific ultrasound contrast agent, for imaging prostate tumors in an orthotopic model in the rat. [Invest Radiol] Synthesis and Characterization of Amphiphilic Lipopolymers for Micellar Drug Delivery Embelin loaded Poly(ethylene glycol)-block-poly(2-methyl-2-carboxyl-propylene carbonate-graft-dodecanol) (PEG-PCD) micelles showed significant inhibition of C4-2 prostate cancer cell proliferation, while no obvious cellular toxicity was observed for blank micelles. [Biomacromolecules] CLINICAL RESEARCH MRS-Guided HDR Brachytherapy Boost to the Dominant Intraprostatic Lesion in High Risk Localised Prostate Cancer Inclusion of magnetic resonance spectroscopy (MRS) information on the location of dominant lesion allows a safe increase of the dose to the dominant lesion while dose to the remaining target can be even substantially decreased keeping the same, high tumour control probability. [BMC Cancer] Metronomic Administration of Zoledronic Acid and Taxotere Combination in Castration Resistant Prostate Cancer Patients. Phase I ZANTE Trial The bi-weekly combination of docetaxel (50mg/m2) followed by zoledronic acid was feasible and show promising anti-tumor activity. [Cancer Biol Ther] A Generalized Linear-Quadratic Model for Radiosurgery, Stereotactic Body Radiation Therapy, and High-Dose Rate Brachytherapy Researchers developed a generalized linear-quadratic model that encompasses the entire range of possible dose delivery patterns and derived formulas for special radiotherapy schemes. [Sci Transl Med]
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POLICY NEWS NIH Director Collins Says Cell Ruling Won’t Halt Most Ongoing Grants National Institutes of Health (NIH) Director Francis Collins said that the court injunction blocking federally funded research on human embryonic stem cells will not affect grant payments that have already gone out the door this year. [National Institutes of Health, United States] NIH Director’s Response to Stem Cell Injunction [National Institutes of Health, United States] Office of the Director, National Institutes of Health; Notice of Meeting (FR Doc. 2010-20861) [National Institutes of Health, United States] Center for Scientific Review; Notice of Closed Meetings (FR Doc. 2010-21357) [National Institutes of Health, United States] National Cancer Institute; Notice of Closed Meeting (FR Doc. 2010-21282) [National Institutes of Health, United States] National Human Genome Research Institute; Notice of Closed Meeting (FR Doc. 2010-21317) [National Institutes of Health, United States] National Human Genome Research Institute; Notice of Meetings (FR Doc. 2010-20858) [National Institutes of Health, United States] National Center for Research Resources; Notice of Closed Meeting (FR Doc. 2010-21280) [National Institutes of Health, United States] National Cancer Institute’s Best Practices for Biospecimen Resources (FR Doc. 2010-20872) [National Institutes of Health, United States] Revolutionary Genome Sequencing Technologies — The $1000 Genome (SBIR [R43/R44]) (RFA-HG-10-014) [National Institutes of Health, United States] Food and Drug Administration Clinical Trial Requirements, Regulations, Compliance, and Good Clinical Practice; Public Workshop [FR Doc. 2010-20834] [Food and Drug Administration, United States]
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EVENTS (Listed by Date) Prostate Cancer Research Institute Conference 2010 September 11-12, 2010 Los Angeles, United States International Society for Cellular Therapy (ISCT) – Europe 2nd Regional Meeting September 11-14, 2010 Belgirate, Italy Tissue Engineering and Regenerative Medicine International Society (TERMIS) – Asia Pacific 2010 September 15-17, 2010 Sydney, Australia 2010 Prostate Cancer Canada (PCCN) Conference September 22-25, 2010 Toronto, Canada International Society for Cellular Therapy 2nd Annual Symposium on Stem Cell Translation: Best Practices & Regulatory Considerations September 27-28, 2010 San Francisco, United States 35th European Society for Medical Oncology (ESMO) Congress October 8–12, 2010 Milan, Italy Frontiers in Tumour Progression October 24-27, 2010 Madrid, Spain Cancer Pharmacogenetics: Personalising Medicine November 22-24, 2010 Madrid, Spain IMPaCT: Innovative Minds in Prostate Cancer Today 2011 March 9-12, 2011 Orlando, United States Visit our events page to stay up to date with the latest events in the cell, gene and immunotherapy community.
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