Prostate Cell News Volume 1.34 | Sep 10 2010

Constitutively Active Androgen Receptor Splice Variants Expressed in Castration-Resistant Prostate Cancer Require Full-Length Androgen Receptor 
To explore the range of potential androgen receptor (AR) splice variants lacking the ligand binding domain, researchers screened additional human and murine prostate cancer models using conventional and next generation sequencing technologies and detected several structurally diverse AR isoforms. [Proc Natl Acad Sci USA]

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Caltech Scientists Create New Process to “Program” Cancer Cell Death
Researchers at the California Institute of Technology (Caltech) have engineered a fundamentally new approach to killing cancer cells. [Press release from the California Institute of Technology discussing online prepublication in Proceedings of the National Academy of Sciences USA]

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LABORATORY RESEARCH

Selective Cell Death Mediated by Small Conditional RNAs
Here, researchers describe small conditional RNAs that undergo hybridization chain reactions to induce cell death via an innate immune response if and only if a cognate mRNA cancer marker is detected within a cell. [Proc Natl Acad Sci USA]

Epithelial Hic-5/ARA55 Expression Contributes to Prostate Tumorigenesis and Castrate Responsiveness
To determine the role of epithelial Hic-5 in prostate cancer progression and castration responsiveness, researchers compared LNCaP cells having Hic-5 stably expressed with the parental LNCaP cells following tissue recombination xenografts with mouse prostate stromal cells. [Oncogene]

Expression of Receptors for Luteinizing Hormone-Releasing Hormone (LH-RH) in Prostate Cancers following Therapy with LH-RH Agonists
To better characterize expression of tumoral luteinizing hormone-releasing hormone (LH-RH) receptors, specimens of prostate cancer from various cohorts of patients were analyzed. [Clin Cancer Res]

The Tocopherol Transfer Protein Sensitizes Prostate Cancer Cells to Vitamin E
Researchers hypothesized that over-expression of the tocopherol transfer protein, a vitamin E-binding protein that regulates tocopherol status, will sensitize prostate cancer cells to the anti-proliferative actions of the vitamin. [J Biol Chem]

Embelin Suppresses Osteoclastogenesis Induced by RANKL and Tumor Cells In Vitro Through Inhibition of the NF-KappaB Cell Signaling Pathway
Researchers investigated whether embelin could inhibit osteoclastogenesis-associated bone loss induced by RANKL and by tumor cells in vitro. [Mol Cancer Res]

CLINICAL RESEARCH

Metronomic Administration of Zoledronic Acid and Taxotere Combination in Castration Resistant Prostate Cancer Patients – Phase I ZANTE Trial
Docetaxel and zoledronic acid are effective in patients with hormone resistant prostate cancer (HRPC) with bone metastases. A phase I clinical trial of metronomic administration of Zoledronic Acid and Taxotere combination (ZANTE trial) in two different sequences was conducted in HRPC. [Cancer Biol Ther]

Sleep and Daily Functioning During Androgen Deprivation Therapy for Prostate Cancer
This study assessed sleep in 60 prostate cancer patients taking androgen deprivation therapy with wrist actigraphy and daily diaries for 7 days. [Eur J Cancer Care]

Antiangiogenic and Antitumor Activity of LP-261, A Novel Oral Tubulin Binding Agent, Alone and in Combination with Bevacizumab
Here, researchers report the results of testing in multiple mouse xenograft models and angiogenesis assays, along with bioavailability studies. [Invest New Drugs]

STEMSOFT® Software Inc. Licenses StemLab® Software to Arizona’s Celebration Stem Cell Centre
STEMSOFT Software Inc., the leading provider of software solutions for the cell therapy and transplant community, is pleased to announce the licensing of StemLab, the leading cell therapy and cord blood banking laboratory software, to the Celebration Stem Cell Centre in Gilbert, Arizona. [STEMSOFT Software Inc. Press Release]

CytRx Initiates Phase II Clinical Trial with Bafetinib in Advanced Prostate Cancer
CytRx Corporation, a biopharmaceutical company specializing in oncology, announced initiation of the PROstate Advanced Cancer Treatment (PROACT) Phase II proof-of-concept clinical trial to evaluate the efficacy and safety of bafetinib in patients with advanced prostate cancer. [CytRx Corporation Press Release]

Study of Investigational Agent Abiraterone Acetate for Metastatic Advanced Prostate Cancer Unblinded After Meeting Pre-Determined Criteria
Ortho Biotech Oncology Research & Development announced that it has unblinded the Phase III study of abiraterone acetate plus prednisone for the treatment of patients with metastatic advanced prostate cancer whose disease has progressed following treatment with one or two chemotherapy regimens at least one of which contained docetaxel. [Johnson and Johnson Press Release]

Notice of Meeting: Secretary’s Advisory Committee on Genetics, Health, and Society (FR Doc. 2010-21532) [Department of Health and Human Services, United States]

Findings of Research Misconduct (NOT-OD-10-132) [Department of Health and Human Services, United States]

Protein Structure Initiative:Biology-Materials Repository (PSI:Biology-MR) (U01) (RFA-GM-11-008) [National Institute of General Medical Sciences, United States]

Developing and Improving Institutional Animal Resources (G20) (RFA-RR-10-011) [National Center for Research Resources, United States]

Clarification on the Roles of NIH Scientific Review Groups (SRG) and Institutional Animal Care and Use Committees (IACUC) in Review of Vertebrate Animal Research (NOT-OD-10-128) [National Institutes of Health, United States]

Clarification of Eligible Institutions for PA-10-050: Omnibus Solicitation of the NIH, CDC, FDA and ACF for Small Business Innovation Research Grant Applications (Parent SBIR [R43/R44]) [National Institutes of Health, United States]

Center for Scientific Review; Amended Notice of Meeting (FR Doc. 2010–21816) [National Institutes of Health, United States]

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