Prostate Cell News Volume 1.37 | Oct 1 2010

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    Prostate Cell News 1.37, October 1, 2010.
    In this issue: Science News  |  Current Publications  |  Industry News  |  Policy News  |  EventsSubscribe  |  Unsubscribe

    TOP STORY

    Gene Variations that Alter Key Enzyme Linked to Prostate Cancer 
    Researchers have found that variations in a gene for an enzyme involved in cell energy metabolism appear to increase the risk for prostate cancer. [Press release from the National Institutes of Health discussing online prepublication in The Journal of Clinical Endocrinology and Metabolism]

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    SCIENCE NEWS

    Biomarker Panel Identifies Prostate Cancer with 90 Percent Accuracy
    Researchers in England say they have discovered a set of biomarkers that can distinguish prostate cancer from benign prostate disease and healthy tissue with 90 percent accuracy. [Press release from the American Association for Cancer Research (AACR) discussing data presented at the Fourth AACR International Conference on Molecular Diagnostics in Cancer Therapeutic Development]

    Jevtana(R) Improves Survival in Advanced Prostate Cancer Patients
    Sanofi-aventis announced that data from the Phase III TROPIC study, which was the basis for the U.S. Food and Drug Administration (FDA) approval of Jevtana® (cabazitaxel) Injection, was published. [Press release from Sanofi-aventis discussing online prepublication in The Lancet]

    Surgery Found Effective for Patients with Aggressive Prostate Cancer
    In one of the first studies to focus exclusively on the outcomes after treatment for patients with high-risk prostate cancer, researchers have found that surgery provides high survival rates. [Press release from Mayo Clinic Press Release discussing data presented at the North Central Section of the American Urological Association’s 84th Annual Meeting]

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    CURRENT PUBLICATIONS (Ranked by Impact Factor of the Journal)

    LABORATORY RESEARCH

    LIM Kinases are Required for Invasive Path Generation by Tumor and Tumor-Associated Stromal Cells
    Using siRNA-mediated knockdown or a novel small molecule inhibitor, researchers show LIMK was required for path generation by leading tumor cells and nontumor stromal cells during collective tumor cell invasion. [J Cell Biol]

    Sildenafil Increases Chemotherapeutic Efficacy of Doxorubicin in Prostate Cancer and Ameliorates Cardiac Dysfunction
    Researchers have shown that the potent phosphodiesterase-5 (PDE-5) inhibitor sildenafil (Viagra) induces a powerful effect on reduction of infarct size following ischemia/reperfusion injury and improvement of left ventricular dysfunction in the failing heart after myocardial infarction or doxorubicin (DOX) treatment. [Proc Natl Acad Sci USA]

    Androgens Suppress EZH2 Expression Via Retinoblastoma (RB) and p130-Dependent Pathways: A Potential Mechanism of Androgen-Refractory Progression of Prostate Cancer
    The results reveal that androgens function as an epigenetic regulator in prostatic cells by repression of EZH2 expression through the retinoblastoma protein and p130-dependent pathways. [Endocrinology]

    Polymorphic Variation in the Androgen Receptor Gene: Association with Risk of Testicular Germ Cell Cancer and Metastatic Disease
    The findings strengthen the hypothesis of the importance of androgen action in the aetiology and pathogenesis of testicular malignancy. [Eur J Cancer]

    CD4 T Cell-Mediated Immune Response to Prostatic Proteins in HLA-DRB1*1503 Transgenic Mice and Identification of a Novel HLA-DRB1*1503-Restricted T Cell Epitope From Human Prostatic Acid Phosphatase
    The data demonstrate a disparity in CD4 T cell immune reactivity to prostate-specific antigen and prostatic acid phosphatase between HLA-DRB1*1501 and -DRB1*1503 alleles in human leukocyte antigen transgenic mouse models. It is possible that such immunological differences could contribute to racial disparity in prostate cancer outcome. [Prostate]

    CLINICAL RESEARCH

    Prednisone Plus Cabazitaxel or Mitoxantrone for Metastatic Castration-Resistant Prostate Cancer Progressing After Docetaxel Treatment: A Randomised Open-Label Trial
    Researchers aimed to compare the efficacy and safety of cabazitaxel plus prednisone with those of mitoxantrone plus prednisone in men with metastatic castration-resistant prostate cancer with progressive disease after docetaxel-based treatment. [Lancet]

    DDPC: Dragon Database of Genes Associated with Prostate Cancer
    Researchers have developed Dragon Database of Genes associated with Prostate Cancer (DDPC) as an integrated knowledgebase of genes experimentally verified as implicated in prostate cancer. [Nucleic Acids Res]

    Structural Decay of Bone Microarchitecture in Men with Prostate Cancer Treated with Androgen Deprivation Therapy
    Researchers investigated changes in bone microarchitecture in 26 men with nonmetastatic prostate cancer during the first year of androgen deprivation therapy using the new technique of high-resolution peripheral quantitative computed tomography. [J Clin Endocrinol Metab]

    Presence of the Metabolic Syndrome is Associated with Shorter Time to Castration-Resistant Prostate Cancer
    This preliminary data suggest that metabolic syndrome is a risk factor for earlier development of castration-resistant prostate cancer and support the need for a prospective evaluation of this finding. [Ann Oncol]



    INDUSTRY NEWS

    OncoGenex Pharmaceuticals Announces Initiation of a Phase II Trial Evaluating OGX-427 Treatment in Men with Advanced Prostate Cancer
    OncoGenex Pharmaceuticals, Inc. announced the initiation of a randomized, controlled, investigator-sponsored Phase II trial of OGX-427 in men with metastatic prostate cancer. [OncoGenex Pharmaceuticals, Inc. Press Release]

    Nanobubbles Get a Boost
    Lapotko’s Plasmonic Nanobubble Lab, a joint American-Belarusian laboratory for fundamental and biomedical nanophotonics, has received an R01 grant worth more than $1 million over the next four years to continue developing a method to track down individual cancer cells and destroy them in a single process. [Rice University Press Release]

    Warburg Pincus Agrees to Invest Up to $35 Million in Protox
    Protox Therapeutics Inc., a leader in the development of receptor targeted fusion proteins for the treatment of diseases of the prostate and cancer, and Warburg Pincus, a leading global private equity firm, jointly announced that they have entered into an Investment Agreement. [Protox Therapeutics Inc. Press Release]

    Dendreon Announces Presentation of PROVENGE Data at the 25th International Society for Biological Therapy of Cancer Annual Meeting
    Dendreon Corporation announced PROVENGE(R) (sipuleucel-T) data presentations taking place at the 25th International Society for Biological Therapy of Cancer (iSBTc) annual meeting in Washington, D.C. [Dendreon Corporation Press Release]

    AstraZeneca’s Zibotentan Flunks Late-Stage Prostate Cancer Trial
    AstraZeneca has suffered a setback in its oncology drug development strategy. The pharma giant reported that the closely watched prostate cancer therapy zibotentan failed a late-stage trial. [FierceBiotech]



    POLICY NEWS

    NIH Grants Will Advance Studies of the Form and Function of Proteins
    The National Institutes of Health has awarded 23 grants for structural biology research totaling up to $290 million over five years. [National Institutes of Health, United States]

    NCBI Launches the Database of Genomic Structural Variations
    The National Institutes of Health announced the launch of a new resource, called the Database of Genomic Structural Variation, or dbVar, to help scientists understand how differences in DNA contribute to human health and disease. [National Institutes of Health, United States]

    NIH Releases Biennial Report of the Director
    Dr. Francis S. Collins, M.D., Ph.D, director of the National Institutes of Health, announced the release of the Biennial Report of the Director, NIH, for fiscal years 2008 and 2009. The report provides an integrated portrait of NIH research activities, making it easy for Congress, advocates and patient groups and the general public to understand the many activities of the agency. [National Institutes of Health, United States]

    The NCI Cancer Immunotherapy Trials Network (CITN) Seeks Member Clinical Sites (NOT-CA-10-034) [National Institutes of Health, United States]

    Cancer Diagnostic and Therapeutic Agents Enabled by Nanotechnology (SBIR [U43/U44]) (PAR-10-286) [National Institutes of Health, United States]

    Office of Biotechnology Activities, Office of Science Policy, Office of the Director; Notice of Meeting (FR Doc. 2010-23947) [National Institutes of Health, United States]

    National Center for Research Resources; Notice of Closed Meeting (FR Doc. 2010-23852) [National Institutes of Health, United States]

    Center for Scientific Review; Amended Notice of Meeting (FR Doc. 2010-23847) [National Institutes of Health, United States]

    Center for Scientific Review; Notice of Closed Meeting (FR Doc. 2010-23849) [National Institutes of Health, United States]

    Center for Scientific Review; Notice of Closed Meetings (FR Doc. 2010-23860) [National Institutes of Health, United States]



    EVENTS (Listed by Date)

    35th European Society for Medical Oncology (ESMO) Congress
    October 8-12, 2010
    Milan, Italy

    American Association for Cancer Research (AACR) Translational Cancer Research for Basic Scientists
    October 17-22, 2010
    Boston, United States

    6th Modern Drug Discovery & Development Summit (M3D)
    October 20-22, 2010
    San Francisco, United States

    American Institute for Cancer Research (AICR) 2010 Annual Cancer Research Conference
    October 21-22, 2010
    Washington, DC, United States

    MENA Oncology Conference
    October 22-23, 2010
    Cairo, Egypt

    Frontiers in Tumour Progression
    October 24-27, 2010
    Madrid, Spain

    Select Biosciences 3rd Annual Molecular Diagnostics World Congress
    October 28-29, 2010
    San Diego, United States

    UAE Cancer Congress 2010
    October 28-30, 2010
    Dubai, United Arab Emirates

    6th National Cancer Research Institute (NCRI) Conference
    November 7-10, 2010
    Liverpool, United Kingdom

    9th Annual American Association for Cancer Research (AACR) International Conference: Frontiers in Cancer Prevention Research
    November 7-10, 2010
    Philadelphia, United States

    22nd European Organization for Research and Treatment of Cancer (EORTC)-National Cancer Institute (NCI)-American Association for Cancer Research (AACR) Symposium: Molecular Targets and Cancer Therapeutics
    November 16-19, 2010
    Berlin, Germany

    Cancer Pharmacogenetics: Personalizing Medicine
    November 22-24, 2010
    Madrid, Spain

    The 10th Annual Meeting of the Society Of Urologic Oncology (SUO) – 10th Annual Winter Meeting
    December 3-5, 2010
    Bethesda, United States

    33rd Annual San Antonio Breast Cancer Symposium
    December 8-12, 2010
    San Antonio, United States

    American Association for Cancer Research (AACR) Stem Cells, Development, and Cancer
    March 3-6, 2011
    Vancouver, Canada

    IMPaCT: Innovative Minds in Prostate Cancer Today 2011
    March 9-12, 2011
    Orlando, United States

    The 6th International Conference on Oncolytic Viruses as Cancer Therapeutics
    March 16-19, 2011
    Las Vegas, United States

    American Association for Cancer Research (AACR) 102nd Annual Meeting 2011
    April 2-6, 2011
    Orlando, United States

    International Society for Stem Cell Research (ISSCR) 9th Annual Meeting
    June 15-18, 2011
    Toronto, Canada

    American Association for Cancer Research (AACR) Cancer Research Imaging Camp
    June 19-24, 2011
    St. Louis, United States

    Visit our events page to stay up to date with the latest events in the cell, gene and immunotherapy community.


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