SCIENCE NEWS
Defective Cell Surface “Glue” Is Key to Tumor Invasion
The study shows that a non-adhesive form of N-cadherin, termed proNcad is present in a much higher proportion on the surfaces of the most invasive melanoma, brain tumor cells, breast cancer and prostate tumor cells, compared to less invasive tumor cells. [Press release from McGill University Health Center discussing online prepublication in Neoplasia]
UC Riverside Researchers Identify Components in Pomegranate Juice That Could Stop Cancer From Spreading
Researchers have identified components in pomegranate juice that both inhibit the movement of cancer cells and weaken their attraction to a chemical signal that promotes the metastasis of prostate cancer to the bone. [Press release from the University of California, Riverside discussing data presented at the 50th Annual Meeting of the American Society for Cell Biology]
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CURRENT PUBLICATIONS (Ranked by Impact Factor of the Journal)
LABORATORY RESEARCH
The Phosphorylation of the Androgen Receptor by TFIIH Directs the Ubiquitin/Proteasome Process
In response to hormonal stimuli, a cascade of hierarchical post-translational modifications of nuclear receptors are required for the correct expression of target genes. Here, researchers show that the transcription factor TFIIH, via its cdk7 kinase, phosphorylates the androgen receptor (AR) at position AR/S515. [EMBO J]
Dual-Aptamer-Based Delivery Vehicle of Doxorubicin to Both PSMA (+) and PSMA (-) Prostate Cancers
Researchers have designed a dual-aptamer complex specific to both prostate-specific membrane antigens (+) and (-) prostate cancer cells. [Biomaterials]
Wnt/Beta-Catenin Activation Promotes Prostate Tumor Progression in a Mouse Model
Combining expression of both Wnt-signaling and Tag expression in the mouse prostate, researchers have studied the role of Wnt/beta-catenin signaling in the progression from mouse prostatic intraepithelial neoplasia to adenocarcinoma. [Oncogene]
Polymorphisms Inside MicroRNAs and MicroRNA Target Sites Predict Clinical Outcomes in Prostate Cancer Patients Receiving Androgen-Deprivation Therapy
Researchers systematically evaluated 61 common single nucleotide polymorphisms inside miRNAs and miRNA target sites in a cohort of 601 men with advanced prostate cancer treated with androgen-deprivation therapy. [Clin Cancer Res]
Expression of Neuregulin 4 Splice Variants in Normal Human Tissues and Prostate Cancer and Their Effects on Cell Motility
The neuregulin 4 gene encodes at least five different variants (designated A1, A2, B1, B2 and B3) produced as a result of alternative splicing. Researchers have shown in a panel of prostate cancers that each form is present to differing degrees, and that principal component analysis indicates that there are three patterns of expression. The data suggest that the different forms have varied sites of expression and function, and this includes effects on cell architecture and motility. [Endocr Relat Cancer]
Mechanisms of Nitric Oxide-Mediated Inhibition of EMT in Cancer: Inhibition of the Metastasis-Inducer Snail and Induction of the Metastasis-Suppressor RKIP
Researchers show that treatment of human prostate metastatic cell lines with the nitric oxide donor, DETANONOate, inhibits epithelial to mesenchymal transition and reverses both the mesenchymal phenotype and the cell invasive properties. [Cell Cycle]
Gene Expression Profiling of the Androgen Independent Prostate Cancer Cells Demonstrates Complex Mechanisms Mediating Resistance to Docetaxel
The molecular mechanisms conferring resistance to docetaxel in prostate cancer patients remain partially understood. Researchers generated docetaxel resistant derivatives of the androgen independent prostate cancer cell lines PC-3 and DU-145. [Cancer Biol Ther]
CLINICAL RESEARCH
Genetic Correction of PSA Values Using Sequence Variants Associated with PSA Levels
To search for sequence variants that associate with prostate-specific antigen (PSA) levels, researchers performed a genome-wide association study and follow-up analysis using PSA information from 15,757 Icelandic and 454 British men not diagnosed with prostate cancer. [Sci Transl Med]
Comparison of Health-Related Quality of Life 5 Years After SPIRIT: Surgical Prostatectomy Versus Interstitial Radiation Intervention Trial
Researchers report health-related quality of life at a mean of 5.3 years for 168 trial-eligible men who either chose or were randomly assigned to radical prostatectomy or brachytherapy following a multidisciplinary educational session. [J Clin Oncol]
Variation in Quality of Care Among Older Men With Localized Prostate Cancer
The objective of this study was to assess the racial and ethnic disparities in outcomes and their association with process-of-care measures for elderly Medicare recipients with localized prostate cancer. [Cancer]
Early Hypofractionated Salvage Radiotherapy for Postprostatectomy Biochemical Recurrence
Postprostatectomy adjuvant or salvage radiotherapy, when using standard fractionation, requires 6.5 to 8 weeks of treatment. The authors report on the safety and efficacy of an expedited radiotherapy course for salvage prostate radiotherapy. [Cancer]
Metformin and the Incidence of Prostate Cancer in Patients with Type 2 Diabetes
The objective of this study was to determine whether metformin decreases the risk of prostate cancer in patients with type 2 diabetes. [Cancer Epidemiol Biomarkers Prev]
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EVENTS (Listed by Date)
American Association for Cancer Research (AACR) Targeting PI3K/mTOR Signaling in Cancer
February 24-27, 2011 San Francisco, United States Cell Culture World Congress 2011 – Optimising Cell Culture Development for Biopharmaceutical, Bioprocessing and Manufacture
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